The Journal of Nutritional Biochemistry
Volume 11, Issue 2 , Pages 81-86 , February 2000

Participation of blood cells in the changes of blood amino acid concentrations during maximal exercise

  • A. Aguiló

      Affiliations

    • Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Balears, Spain
    • ,
  • E. Castaño

      Affiliations

    • Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Balears, Spain
    • ,
  • P. Tauler

      Affiliations

    • Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Balears, Spain
    • ,
  • M.P. Guix

      Affiliations

    • Servicio de Análisis Clı́nicos, Laboratorio del Carmen, Hospital Son Dureta, Balears, Spain
    • ,
  • N. Serra

      Affiliations

    • Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Balears, Spain
    • ,
  • A. Pons

      Affiliations

    • Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Balears, Spain
    • Corresponding Author InformationAddress correspondence to Dr. A. Pons, Bioquı́mica i Biologia Molecular, Departament de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Cra Valldemossa km 7.5, 07071-Palma de Mallorca, Balears, Spain

Received 17 June 1999 ,Accepted 25 October 1999.

References 

  1. Newsholme EA, Blomstrand E. The plasma level of some amino acids and physical and mental fatigue. Experientia. 1996;52:413–415
  2. Fernstrom JD. Aromatic amino acids and monoamine synthesis in the CNS (Influence of diet). J. Nutr. Biochem. 1990;10:508–517
  3. Blomstrand E, Hassmén B, Ekblom B, Newsholme EA. Administration of branched-chain amino acids during sustained exercise–effects on performance and on plasma concentration of some amino acids. Eur. J. Appl. Physiol. 1991;63:83–88
  4. Newsholme EA, Blomstrand E, Hassmén P, Ekblom B. Physical and mental fatigue (Do changes in plasma amino acids play a role?). Biochem. Soc. Trans. 1991;19:358–362
  5. Newsholme, E.A. and Blomstrand, E. (1995). Tryptophan, 5hydroxytryptamine and a possible explanation for central fatigue. Adv. Exp. Med. Biol. 384,315–320
  6. Elwyn DH, Launder WJ, Parikh HC, Wise EM. Roles of plasma erythrocytes in interorgan transport of amino acid in dogs. Am. J. Physiol. 1972;222:1333–1342
  7. Felig P. Amino acid metabolism in man. Annu. Rev. Biochem. 1975;44:933–952
  8. Felig P, Wahren J, Raf L. Evidence of interorgan amino acid transport by blood cells in humans. Proc. Natl. Acad. Sci. USA. 1973;70:1775–1779
  9. Picó C, Pons A, Palou A. A significant pool of amino acids is adsorbed on blood cell membranes. Biosci. Rep. 1991;11:223–230
  10. Picó C, Pons A, Palou A. Effect of diet-induced obesity on kinetic parameters of amino acid uptake by rat erythrocytes. Biochem. Int. 1992;28:509–517
  11. Picó C, Pons A, Palou A. Decrease of the pool of amino acids adsorbed on blood cell membranes caused by starvation in rats. Life Sci. 1995;7:675–683
  12. Proenza AM, Palou A, Roca P. Amino acid distribution in human blood. A significant pool of amino acids adsorbed onto blood cell membranes. Biochem. Mol. Biol. Int. 1994;34:971–982
  13. Proenza AM, Roca P, Virgili J, Remesar X, Alemany M, Palou A. Estrogen effects on blood amino acid compartmentation. Life Sci. 1995;57:1589–1597
  14. Serra F, Picó C, Johnston J, Carnie J, Palou A. Opposite response to starvation of Trp/LNAA in lean and obese Zucker rats. Biochem. Mol. Biol. Int. 1993;29:483–491
  15. Gianotti M, Roca P, Palou A. The effects of cafeteria diet induced obesity on rat blood amino acid compartmentation. Arch. Int. Physiol. Biochim. 1990;98:155–161
  16. Serra F, Johnston J, Carnie J, Palou A. Altered blood amino acid distribution in genetically obese mice. Biochim. Biophys. Acta. 1991;1097:289–292
  17. Van Hall G, Saris WH, Wagenmakers AJ. Effect of carbohydrate supplementation on plasma glutamine during prolonged exercise and recovery. Int. J. Sports Med. 1998;19(2):82–86
  18. Arola LL, Herrera E, Alemany M. A new method for deproteinization of small samples of blood plasma for amino acid determination. Anal. Biochem. 1977;82:236–239
  19. Bidlingmeyer BA, Cohen SA, Tarvin TL. Rapid analysis of amino acids using the column derivatization. J. Chromatogr. 1984;336:93–104
  20. Parera M, Guix P, Pérez G, Quetglas P, Fuentespina E, Llompart I. Estudio del error aleatorio en distintos parámetros de rutina bioquı́mica en el autoanalizador DAX-78. Quim. Clin. 1996;15:232–240
  21. Ferrando A, Bobadilla IG, Bobadilla MS, Palou A, Alemany M. Comparative estimation of haematocrit and trapped plasma in the packed cell volume in man, rabbit and chicken blood. Comp. Biochem. Physiol. 1981;70A:611–613
  22. Katz, A., Broberg, S., Shalin, K., and Wahren, J. (1986). Muscle ammonia and amino acid metabolism during dynamic exercise in man. Clin. Physiol. 6, 365–379
  23. Blomstrand E, Andersson S, Hassmén P, Ekblom B, Newsholme EA. Effect of branched-chain amino acid and carbohydrate supplementation on the exercise-induced change in plasma and muscle concentration of amino acids in human subjects. Acta Physiol. Scand. 1995;153:87–96
  24. Montain SJ, Coyle EF. Fluid ingestion during exercise increases skin blood flow independent of increases in blood volume. J. Appl. Physiol. 1992;83:903–910
  25. Lemon PWR. Protein and amino acid needs of the strength athlete. Int. J. Sport Nutr. 1991;1:127–145
  26. Christensen HN. Role of amino acid transport and countertransport in nutrition and metabolism. Physiol. Rev. 1990;70:43–77
  27. Ahlborg G, Felig P, Hagenfeldt L. Substrate turnover during prolonged exercise in man. J. Clin. Invest. 1974;53:1080–1090
  28. Pericás J, Picó C, Matamala JC, Palou A, Pons A. Metabolic utilization of muscular L-proline in 24-hr starved rats. Int. J. Biochem. 1992;11:1725–1730
  29. Phang JM, Yeh GC, Hagedorn CH. The intercellular proline cycle. Life Sci. 1980;28:53–58
  30. Picó C, Pons A, Palou A. Regulation of rat erythrocyte L-glutamine, L-glutamate and L-lysine uptake by short term starvation. Int. J. Biochem. 1992;24:1731–1735

PII: S0955-2863(99)00073-X

The Journal of Nutritional Biochemistry
Volume 11, Issue 2 , Pages 81-86 , February 2000

Article Tools