The Journal of Nutritional Biochemistry
Volume 22, Issue 6 , Pages 554-559 , June 2011

Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats

  • Maria Esméria Corezola do Amaral

      Affiliations

    • Centro Universitário Hermínio Ometto, Programa de Pós Graduação em Ciências Biomédicas - UNIARARAS, Araras, SP, Brasil
    • Corresponding Author InformationCorresponding authors. Tel.: +55 19 3543 1400. Antonio C. Boschero is to be contacted at State University of Campinas (UNICAMP), Anatomia, Biologia Celular e Fisiologia e Biofísica, Rua Charles Darwin s/n, 13083-970, Campinas, SP, BR, 00 55 19 35216202, 00 55 19 35216185.
  • ,
  • Mirian Ueno

      Affiliations

    • Centro Universitário Hermínio Ometto, Programa de Pós Graduação em Ciências Biomédicas - UNIARARAS, Araras, SP, Brasil
  • ,
  • Camila A.M. Oliveira

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
  • ,
  • Natália C. Borsonello

      Affiliations

    • Centro Universitário Hermínio Ometto, Programa de Pós Graduação em Ciências Biomédicas - UNIARARAS, Araras, SP, Brasil
  • ,
  • Emerielle C. Vanzela

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
  • ,
  • Rosane A. Ribeiro

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
  • ,
  • Patricia L. Alves

      Affiliations

    • Centro Universitário Hermínio Ometto, Programa de Pós Graduação em Ciências Biomédicas - UNIARARAS, Araras, SP, Brasil
  • ,
  • Helena C. Barbosa

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
  • ,
  • Everardo M. Carneiro

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
  • ,
  • Antonio C. Boschero

      Affiliations

    • Departamento de Anatomia, Biologia Celular, Fisiologia e Biofísica. Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil
    • Corresponding Author InformationCorresponding authors. Tel.: +55 19 3543 1400. Antonio C. Boschero is to be contacted at State University of Campinas (UNICAMP), Anatomia, Biologia Celular e Fisiologia e Biofísica, Rua Charles Darwin s/n, 13083-970, Campinas, SP, BR, 00 55 19 35216202, 00 55 19 35216185.

Received 19 November 2009 ,Revised 13 April 2010 ,Accepted 20 April 2010.

References 

  1. Redman LM, Ravussin E. Endocrine alterations in response to calorie restriction in humans. Mol Cell Endocrinol. 2009;299:129–136
  2. McCay CM, Crowell MF, Maynard LA. The effect of retarded growth upon the length of life and upon the ultimate body size. J Nutr. 1935;10:63–79
  3. Fontana L. The scientific basis of caloric restriction leading to longer life. Curr Opin Gastroenterol. 2009;25:144–150
  4. Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 2009;325:201–204
  5. Longo VD, Finch CE. Evolutionary medicine: from dwarf model systems to healthy centenarians?. Science. 2003;299:1342–1346
  6. Smith JV, Heilbronn LK, Ravussin E. Energy restriction and aging. Curr Opin Clin Nutr Metab Care. 2004;7:615–622
  7. Masoro EJ. Overview of the effects of food restriction. Prog Clin Biol Res. 1989;287:27–35
  8. Martin B, Golden E, Egan JM, Mattson MP, Maudsley S. Reduced energy intake: the secret to a long and healthy life?. IBS J Sci. 2007;2:35–39
  9. Barzilai N, Bartke A. Biological approaches to mechanistically understand the healthy life span extension achieved by calorie restriction and modulation of hormones. J Gerontol. 2009;2:187–191
  10. McCarter R, Mejia W, Ikeno Y, Monnier V, Kewitt K, Gibbs M, et al. Plasma glucose and the action of calorie restriction on aging. J Gerontol A Biol Sci Med Sci. 2007;62:1059–1070
  11. Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature. 2006;444:868–874
  12. Leibiger IB, Berggren PO. A SIRTain role in pancreatic beta cell function. Cell Metab. 2005;2:80–82
  13. Manco M, Mingrone G. Effects of weight loss and calorie restriction on carbohydrate metabolism. Curr Opin Clin Nutr Metab Care. 2005;8:431–439
  14. Bordone L, Guarente L. Sirtuins and b-cell function. Diabetes, Obesity and Metabolism. 2007;9:23–27
  15. Moynihan KA, Grimm AA, Plueger MM, Bernal-Mizrachi E, Ford E, Cras-Meneur C, et al. Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice. Cell Metab. 2005;2:105–117
  16. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006;126:941–954
  17. Cantó C, Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab. 2009;20:325–331
  18. Yang T, Fu M, Pestell R, Sauve AA. SIRT1 and endocrine signaling. Trends Endocrinol Metab. 2006;17:186–191
  19. Argmann C, Auwerx J. Insulin secretion: SIRT4 gets in on the act. Cell. 2006;126:837–839
  20. Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, et al. Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J Biol Chem. 2007;282:33583–33592
  21. Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol. 2005;6:298–305
  22. Milanski M, Arantes VC, Ferreira F, De Barros Reis MA, Carneiro EM, Boschero AC, et al. Low-protein diets reduce PKAalpha expression in islets from pregnant rats. J Nutr. 2005;135(8):1873–1878
  23. Scott AM, Atwater I, Rojas E. A method for the simultaneous measurement of insulin release and B cell membrane potential in single mouse islets of Langerhans. Diabetologia. 1981;21:470–475
  24. Lo S, Russell JC, Taylor AW. Determination of glycogen in small tissue samples. J Appl Physiol. 1970;28:234–236
  25. Floch JP, Escuyer P, Baudin E, Baudon D, Perlemuter L. Blood glucose area under the curve. Methodological aspects. Diabetes Care. 1990;13:172–175
  26. Boschero AC, Bordin S, Herchuelz A, Lebrun P. Effects of glucose on 45Ca2+ outflow, cytosolic Ca2+ concentration and insulin release from freshly isolated and cultured adult rat islets. Cell Calcium. 1990;11:603–609
  27. Vanzela EC, Ribeiro RA, de Oliveira CA, Rodrigues FB, Bonfleur ML, Carneiro EM, et al. Pregnancy restores insulin secretion from pancreatic islets in cafeteria diet-induced obese rats. Am J Physiol Regul Integr Comp Physiol. 2010;298(2):R320–328
  28. Arias EB, Cartee GD. In vitro stimulation of calorie restriction-induced decline in glucose and insulin leads to increase insulin-stimulated glucose transport in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2007;293:E1782–E1788
  29. Dean DJ, Cartee GD. Calorie restriction increases insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate-1 in rat skeletal muscle. Acta Physiol Scand. 2000;169:133–139
  30. Carrie EM, Davidson RT, Cartee GD. Brief calorie restriction increases Akt2 phosphorylation in insulin-stimulated rat skeletal muscle. Am J Physiol Endocrinol Metab. 2003;285:693–700
  31. McCurdy CE, Davidson RT, Cartee GD. Calorie restriction increases the ratio of phosphatidylinositol 3-kinase catalytic to regulatory subunits in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2005;288:E996–E1001
  32. Wang Z, Masternak MM, Al-Regaiey KA, Bartke A. Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology. 2007;148:2845–2853
  33. Gao Z, Young RA, Li G, Najafi H, Buettger C, Sukumvanich SS, et al. Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Endocrinology. 2003;144:1949–1957
  34. Newsholme P, Brennan L, Rubi B, Maechler P. New insights into amino acid metabolism, beta-cell function and diabetes. Clin Sci (Lond). 2005;108:185–194
  35. Zawalich WS, Zawalich KC. Glucose-induced insulin secretion from islets of fasted rats: modulation by alternate fuel and neurohumoral agonists. J Endocrinol. 2000;166:111–120
  36. Bordone L, Motta MC, Picard F, Robinson A, Jhala US, Apfeld J, et al. SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol. 2006;4:e31
  37. Ramsey KM, Mills KF, Satoh A, Imai S. Age-associated loss of SIRT1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific SIRT1-overexpressing (BESTO) mice. Aging Cell. 2008;7:78–88

 This work was partly supported by the following Brazilian foundations: Conselho Nacional de Pesquisa (CNPq), Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP), Progroma dePós Graduação em Ciências Biomédicas - UNIARARAS, and Instituto Nacional de Obesidade e Diabetes (INOD).

PII: S0955-2863(10)00115-4

doi: 10.1016/j.jnutbio.2010.04.010

The Journal of Nutritional Biochemistry
Volume 22, Issue 6 , Pages 554-559 , June 2011