The Journal of Nutritional Biochemistry
Volume 22, Issue 5 , Pages 487-494 , May 2011

Saturated fat intake and alcohol consumption modulate the association between the APOE polymorphism and risk of future coronary heart disease: a nested case-control study in the Spanish EPIC cohort

  • Dolores Corella

      Affiliations

    • Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    • Corresponding Author InformationCorresponding author. Genetic and Molecular Epidemiology Unit, School of Medicine, University of Valencia, 15 46010-Valencia, Spain. Tel.: +34 963864800; fax: +34 963864166.
    • ,
  • Olga Portolés

      Affiliations

    • Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    • ,
  • Larraitz Arriola

      Affiliations

    • Public Health Department of Gipuzkoa, Basque Government, San Sebastian, CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • ,
  • María Dolores Chirlaque

      Affiliations

    • Department of Epidemiology, Murcia Regional Health Council, Murcia and CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • ,
  • Aurelio Barrricarte

      Affiliations

    • Public Health Institute of Navarra, Pamplona and CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • Denotes EPIC's Principal Investigator.
    • ,
  • Francesc Francés

      Affiliations

    • Genetic and Molecular Epidemiology Unit, Department of Preventive Medicine, University of Valencia, Valencia and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    • ,
  • José María Huerta

      Affiliations

    • Department of Epidemiology, Murcia Regional Health Council, Murcia and CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • ,
  • Nerea Larrañaga

      Affiliations

    • Public Health Department of Gipuzkoa, Basque Government, San Sebastian, CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • ,
  • Carmen Martínez

      Affiliations

    • Andalusian School of Public Health, Granada y CIBER Epidemiología y Salud Pública CIBERESP, Spain
    • Denotes EPIC's Principal Investigator.
    • ,
  • Pablo Martinez-Camblor

      Affiliations

    • Public Health Department of Gipuzkoa, Basque Government, San Sebastian, CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • ,
  • Esther Molina

      Affiliations

    • Andalusian School of Public Health, Granada y CIBER Epidemiología y Salud Pública CIBERESP, Spain
    • ,
  • Carmen Navarro

      Affiliations

    • Department of Epidemiology, Murcia Regional Health Council, Murcia and CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • Denotes EPIC's Principal Investigator.
    • ,
  • Jose R. Quirós

      Affiliations

    • Public Health and Health Planning Directorate, Asturias, Spain
    • Denotes EPIC's Principal Investigator.
    • ,
  • Laudina Rodríguez

      Affiliations

    • Public Health and Health Planning Directorate, Asturias, Spain
    • ,
  • María José Sánchez

      Affiliations

    • Andalusian School of Public Health, Granada y CIBER Epidemiología y Salud Pública CIBERESP, Spain
    • ,
  • Emilio Ros

      Affiliations

    • Lipid Clinic, Endocrinology and Nutrition Service, IDIBAPS, Hospital Clínic, Barcelona and CIBER Fisiopatología de la Obesidad y Nutrición, ISCIII, Spain
    • ,
  • Nuria Sala

      Affiliations

    • Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
    • ,
  • Carlos A. González

      Affiliations

    • Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
    • Denotes EPIC's Principal Investigator.
    • These senior authors contributed equally to this work.
    • ,
  • Concepción Moreno-Iribas

      Affiliations

    • Public Health Institute of Navarra, Pamplona and CIBER Epidemiología y Salud Pública (CIBERESP), Spain
    • Departments of Pediatrics, Obstetrics and Gynecology, and Preventive Medicine, Universidad Autónoma de Barcelona, Barcelona
    • These senior authors contributed equally to this work.

Received 30 December 2009 ,Accepted 1 April 2010.

References 

  1. Arnett DK, Baird AE, Barkley RA, et al. American Heart Association Council on Epidemiology and Prevention; American Heart Association Stroke Council; Functional Genomics and Translational Biology Interdisciplinary Working Group Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 2007;115:2878–2901
  2. Kris-Etherton PM, Krummel D, Russell ME, Dreon D, Mackey S, Borchers J, et al. The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. J Am Diet Assoc. 1988;88:1373–1400
  3. Hu FB, Stampfer MJ, Manson JE, et al. Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr. 1999;70:1001–1008
  4. Xu J, Eilat-Adar S, Loria C, Goldbourt U, Howard BV, Fabsitz RR, et al. Dietary fat intake and risk of coronary heart disease: the Strong Heart Study. Am J Clin Nutr. 2006;84:894–902
  5. Howard BV, Van Horn L, Hsia J, et al. Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:655–666
  6. Ravnskov U. The questionable role of saturated and polyunsaturated fatty acids in cardiovascular disease. J Clin Epidemiol. 1998;51:443–460
  7. Lovegrove JA, Gitau R. Personalized nutrition for the prevention of cardiovascular disease: a future perspective. J Hum Nutr Diet. 2008;21(4):306–316
  8. Ordovas JM. Nutrigenetics, plasma lipids, and cardiovascular risk. J Am Diet Assoc. 2006;106:1074–1081
  9. Wilson PW, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ, et al. alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. JAMA. 1994;272:1666–1671
  10. Song Y, Stampfer MJ, Liu S. Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Ann Intern Med. 2004;141:137–147
  11. Bennet AM, Di Angelantonio E, Ye Z, et al. Association of apolipoprotein E genotypes with lipid levels and coronary risk. JAMA. 2007;298:1300–1311
  12. Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 1988;8:1–21
  13. Eichner JE, Dunn ST, Perveen G, Thompson DM, Stewart KE, Stroehla BC. Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. Am J Epidemiol. 2002;155:487–495
  14. Muendlein A, Saely CH, Marte T, et al. Synergistic effects of the apolipoprotein E epsilon3/epsilon2/epsilon4, the cholesteryl ester transfer protein TaqIB, and the apolipoprotein C3 −482 C>T polymorphisms on their association with coronary artery disease. Atherosclerosis. 2008;199:179–186
  15. Granér M, Kahri J, Varpula M, et al. Apolipoprotein E polymorphism is associated with both carotid and coronary atherosclerosis in patients with coronary artery disease. Nutr Metab Cardiovasc Dis. 2008;18:271–277
  16. Stengård JH, Pekkanen J, Ehnholm C, Nissinen A, Sing CF. Genotypes with the apolipoprotein epsilon4 allele are predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men. Hum Genet. 1996;97:677–684
  17. Keavney B, Palmer A, Parish S, et al. International Studies of Infarct Survival (ISIS) Collaborators Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk. Int J Epidemiol. 2004;33:1002–1013
  18. Talmud PJ, Lewis SJ, Hawe E, et al. No APOEepsilon4 effect on coronary heart disease risk in a cohort with low smoking prevalence: the Whitehall II study. Atherosclerosis. 2004;177:105–112
  19. Volcik KA, Barkley RA, Hutchinson RG, et al. Apolipoprotein E polymorphisms predict low density lipoprotein cholesterol levels and carotid artery wall thickness but not incident coronary heart disease in 12,491 ARIC study participants. Am J Epidemiol. 2006;164:342–348
  20. Loew M, Hoffmann MM, Hahmann H, März W, Rothenbacher D, Brenner H. Smoking, apolipoprotein E genotype, and early onset of coronary heart disease. Eur J Cardiovasc Prev Rehabil. 2005;12:268–270
  21. Marshall HW, Morrison LC, Wu LL, et al. Apolipoprotein polymorphisms fail to define risk of coronary artery disease. Results of a prospective, angiographically controlled study. Circulation. 1994;89:567–577
  22. Kolovou GD, Daskalova DCh, Hatzivassiliou M, et al. The epsilon 2 and 4 alleles of apolipoprotein E and ischemic vascular events in the Greek population — implications for the interpretation of similar studies. Angiology. 2003;54:51–58
  23. Mamotte CD, Burke V, Taylor RR, van Bockxmeer FM. Evidence of reduced coronary artery disease risk for apolipoprotein epsilon2/3 heterozygotes. Eur J Intern Med. 2002;13:250–255
  24. Koch W, Hoppmann P, Schömig A, Kastrati A. Apolipoprotein E gene epsilon2/epsilon3/epsilon4 polymorphism and myocardial infarction: case-control study in a large population sample. Int J Cardiol. 2008;125:116–117
  25. Vaisi-Raygani A, Rahimi Z, Nomani H, Tavilani H, Pourmotabbed T. The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. Clin Biochem. 2007;40:1150–1156
  26. Lahoz C, Schaefer EJ, Cupples LA, et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis. 2001;154:529–537
  27. Tso TK, Park S, Tsai YH, Williams G, Snook JT. Effect of apolipoprotein E polymorphism on serum lipoprotein response to saturated fatty acids. Lipids. 1998;33:139–148
  28. Loktionov A, Scollen S, McKeown N, Bingham SA. Gene–nutrient interactions: dietary behaviour associated with high coronary heart disease risk particularly affects serum LDL cholesterol in apolipoprotein E epsilon4-carrying free-living individuals. Br J Nutr. 2000;84:885–890
  29. Campos H, D'Agostino M, Ordovás JM. Gene–diet interactions and plasma lipoproteins: role of apolipoprotein E and habitual saturated fat intake. Genet Epidemiol. 2001;20:117–128
  30. Yang Y, Ruiz-Narvaez E, Kraft P, Campos H. Effect of apolipoprotein E genotype and saturated fat intake on plasma lipids and myocardial infarction in the Central Valley of Costa Rica. Hum Biol. 2007;79:637–647
  31. Gylling H, Miettinen TA. Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes. J Lipid Res. 1992;33:1361–1371
  32. Sarkkinen E, Korhonen M, Erkkilä A, Ebeling T, Uusitupa M. Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. Am J Clin Nutr. 1998;68:1215–1222
  33. Savolainen MJ, Rantala M, Kervinen K, et al. Magnitude of dietary effects on plasma cholesterol concentration: role of sex and apolipoprotein E phenotype. Atherosclerosis. 1991;86:145–152
  34. Pasagian-Macaulay A, Aston CE, Ferrell RE, McAllister AE, Wing RR, Kuller LH. A dietary and behavioral intervention designed to lower coronary heart disease. Risk factors are unaffected by variation at the APOE gene locus. Atherosclerosis. 1997;132:221–227
  35. Corella D, Tucker K, Lahoz C, et al. Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study. Am J Clin Nutr. 2001;73:736–745
  36. Djoussé L, Pankow JS, Arnett DK, Eckfeldt JH, Myers RH, Ellison RC. Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Clin Nutr. 2004;80:1639–1644
  37. González CA, Navarro C, Martínez C, et al. The European Prospective Investigation on Diet, Cancer, and Health (EPIC) in Spain. Group EPIC of Spain. Med Clin (Barc). 1994;102:781–785
  38. Riboli E, Kaaks R. The EPIC project: rationale and study design. Int J Epidemiol. 1997;26:S6–S14
  39. Riboli E, Hunt KJ, Slimani N, et al. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr. 2002;5:1113–1124
  40. Danesh J, Saracci R, Berglund G, et al. EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries. Eur J Epidemiol. 2007;22:129–141
  41. Luepker RV, Apple FS, Christenson RH, et al. Case definitions for acute coronary heart disease in epidemiology and clinical research studies: a statement from the AHA Council on Epidemiology and Prevention; AHA Statistics Committee; World Heart Federation Council on Epidemiology and Prevention; the European Society of Cardiology Working Group on Epidemiology and Prevention; Centers for Disease Control and Prevention; and the National Heart, Lung, and Blood Institute. Circulation. 2003;108:2543–2549
  42. Wareham NJ, Jakes RW, Rennie KL, et al. Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr. 2003;6:407–413
  43. EPIC Group of Spain. Relative validity and reproducibility of a diet history questionnaire in Spain. I. Foods. Int J Epidemiol. 1997;26:S91–S99
  44. EPIC Group of Spain. Relative validity and reproducibility of a diet history questionnaire in Spain. II. Nutrients. Int J Epidemiol. 1997;26:S100–S109
  45. Slimani N, Torrent M, Farriols N, et al. European Prospective Investigation into Cancer and Nutrition (EPIC): food composition tables — Spain. Lyon: International Agency for Research on Cancer; 1991;
  46. Pearson TA. Alcohol and heart disease. Circulation. 1996;94:3023–3025
  47. Agudo A, Goñi F, Etxeandia A, et al. Polychlorinated biphenyls in Spanish adults: determinants of serum concentrations. Environ Res. 2009;109:620–628
  48. Francés F, Portolés O, Sorlí JV, Guillén M, González JI, Corella D. Single tube optimisation of APOE genotyping based on melting curve analysis. Clin Biochem. 2008;41:923–926
  49. Corella D, Guillén M, Sáiz C, et al. Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population. Metabolism. 2001;50:936–944
  50. Mukamal KJ, Chung H, Jenny NS, et al. Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. J Am Geriatr Soc. 2006;54:30–37

☆ This study was funded by a research grant (FIS) of the Spanish Ministry of Health (PI041224; PI042342; PI041822; PI042188); RETIC (RD06/0020 and RD07/0067/0006); CIBER OBN 06/03; CIBERESP and the Spanish Regional Governments of Andalusia, Asturias, Basque Country, Murcia and Navarra and the Catalan Institute of Oncology.

☆☆ None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. None of the authors has declared any potential conflict of interest.

PII: S0955-2863(10)00101-4

doi: 10.1016/j.jnutbio.2010.04.003

The Journal of Nutritional Biochemistry
Volume 22, Issue 5 , Pages 487-494 , May 2011

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