The Journal of Nutritional Biochemistry
Volume 21, Issue 12 , Pages 1238-1250 , December 2010

Allicin protects against cardiac hypertrophy and fibrosis via attenuating reactive oxygen species-dependent signaling pathways

  • Chen Liu

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 510080 Guangzhou, China
    • These authors contributed equally to this work.
    • ,
  • Feng Cao

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • These authors contributed equally to this work.
    • ,
  • Qi-Zhu Tang

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • ,
  • Ling Yan

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • ,
  • Yu-Gang Dong

      Affiliations

    • Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 510080 Guangzhou, China
    • ,
  • Li-Hua Zhu

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • ,
  • Lang Wang

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • ,
  • Zhou-Yan Bian

      Affiliations

    • Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China
    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • ,
  • Hongliang Li

      Affiliations

    • Cardiovascular Research Institute of Wuhan University, Wuhan 430060, PR China
    • Corresponding Author InformationCorresponding author. JieFang Road 238, Wuhan 430060, PR China. Tel.: +86 27 88076990; fax: +86 27 88076990.

Received 2 August 2009 ,Revised 25 October 2009 ,Accepted 4 November 2009.

References 

  1. Chien KR. Stress pathways and heart failure. Cell. 1999;98:555–558
  2. Hennersdorf MG, Strauer BE. Arterial hypertension and cardiac arrhythmias. J Hypertens. 2001;19:167–177
  3. Vakili BA, Okin PM, Devereux RB. Prognostic implications of left ventricular hypertrophy. Am Heart J. 2001;141:334–341
  4. Cheng L, Ding G, Qin Q, Huang Y, Lewis W, He N, et al. Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy. Nat Med. 2004;10:1245–1250
  5. Cameron VA, Mocatta TJ, Pilbrow AP, Frampton CM, Troughton RW, Richards AM, et al. Angiotensin type-1 receptor A1166C gene polymorphism correlates with oxidative stress levels in human heart failure. Hypertension. 2006;47:1155–1161
  6. Kumar V, Kitaeff N, Hampton MB, Cannell MB, Winterbourn CC. Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Lett. 2009;583:997–1000
  7. Nadtochiy SM, Burwell LS, Brookes PS. Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol. 2007;42:812–825
  8. Burwell LS, Brookes PS. Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal. 2008;10:579–599
  9. Kwon SH, Pimentel DR, Remondino A, Sawyer DB, Colucci WS. H2O2 regulates cardiac myocyte phenotype via concentration -dependent activation of distinct kinase pathways. J Mol Cell Cardiol. 2003;35:615–621
  10. Li JM, Gall NP, Grieve DJ, Chen M, Shah AM. Activation of NADPH oxidase during progression of cardiac hypertrophy to failure. Hypertension. 2002;40:477–484
  11. Date MO, Morita T, Yamashita N, Nishida K, Yamaguchi O, Higuchi Y, et al. The antioxidant N-2-mercaptopropionyl glycine attenuates left ventricular hypertrophy in vivo murine pressure-overload model. J Am Coll Cardiol. 2002;39:907–912
  12. Higuchi Y, Otsu K, Nishida K, Hirotani S, Nakayama H, Yamaguchi O, et al. Involvement of reactive oxygen species-mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2002;34:233–240
  13. Pimentel DR, Amin JK, Xiao L, Miller T, Viereck J, Oliver-Krasinski J, et al. Reactive oxygen species mediate amplitude-dependent hypertrophic and apoptotic responses to mechanical stretch in cardiac myocytes. Circ Res. 2001;89:453–460
  14. Das DK, Maulik N, Engelman RM. Redox regulation of angiotensin II signaling in the heart. J Cell Mol Med. 2004;8:144–152
  15. Chung LY. The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide. J Med Food. 2006;9:205–213
  16. Hasan N, Yusuf N, Toossi Z, Islam N. Suppression of Mycobacterium tuberculosis induced reactive oxygen species (ROS) and TNF-alpha mRNA expression in human monocytes by allicin. FEBS Lett. 2006;580:2517–2522
  17. Rabinkov A, Miron T, Konstantinovski L, Wilchek M, Mirelman D, Weiner L. The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins. Biochim Biophys Acta. 1998;1379:233–244
  18. Borek C. Antioxidant health effects of aged garlic extract. J Nutr. 2001;131:1010S–1015S
  19. Adetumbi MA, Lau BH. Allium sativum (garlic) — a natural antibiotic. Med. Hypotheses. 1983;12:227–237
  20. Mirelman D, Monheit D, Varon S. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic extract (Allium sativum). J Infect Dis. 1987;156:243–244
  21. Prasad K, Laxdal VA, Yu M, Raney BL. Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem. 1995;148:183–189
  22. Horev-Azaria L, Eliav S, Izigov N, Pri-Chen S, Mirelman D, Miron T, et al. Allicin up-regulates cellular glutathione level in vascular endothelial cells. Eur J Nutr. 2009;48:67–74
  23. Schwartz IF, Hershkovitz R, Iaina A, Gnessin E, Wollman Y, Chernichowski T, et al. Garlic attenuates nitric oxide production in rat cardiac myocytes through inhibition of inducible nitric oxide synthase and the arginine transporter CAT-2 (cationic amino acid transporter-2). Clin Sci (Lond). 2002;102:487–493
  24. Sun X, Ku DD. Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol. 2006;291:H2431–2438
  25. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature. 2004;428:185–189
  26. Tang Q, Cai J, Shen D, Bian Z, Yan L, Wang YX, et al. Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling. J Mol Med. 2009;87:249–260
  27. Li HL, She ZG, Li TB, Wang AB, Yang Q, Wei YS, et al. Overexpression of myofibrillogenesis regulator-1 aggravates cardiac hypertrophy induced by angiotensin II in mice. Hypertension. 2007;49:1399–1408
  28. Li HL, Huang Y, Zhang CN, Liu G, Wei YS, Wang AB, et al. Epigallocathechin-3 gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radic Biol Med. 2006;40:1756–1775
  29. Cole MP, Chaiswing L, Oberley TD, Edelmann SE, Piascik MT, Lin SM, et al. The protective roles of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovasc Res. 2006;69:186–197
  30. Zhao Y, Wang LM, Chaiswing L, Yen HC, Oberley TD, Lien YC, et al. Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions. Free Radic Biol Med. 2006;40:1234–1241
  31. Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, et al. Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol. 2007;43:437–444
  32. van Empel VP, Bertrand AT, van Oort RJ, van der Nagel R, Engelen M, van Rijen HV, et al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006;48:824–832
  33. Tsujimoto I, Hikoso S, Yamaguchi O, Kashiwase K, Nakai A, Takeda T, et al. The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension. 2005;45:921–926
  34. Nakagami H, Takemoto M, Liao JK. NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy. J Mol Cell Cardiol. 2003;35:851–859
  35. Nakamura K, Fushimi K, Kouchi H, Mihara K, Miyazaki M, Ohe T, et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-alpha and angiotensin II. Circulation. 1998;98:794–799
  36. Tanaka K, Honda M, Takabatake T. Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyte. J Am Coll Cardiol. 2001;37:676–685
  37. Kubota T, McTiernan CF, Frye CS, Slawson SE, Lemster BH, Koretsky AP, et al. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ Res. 1997;81:627–635
  38. Kadokami T, Frye C, Lemster B, Wagner CL, Feldman AM, McTiernan CF. Anti-tumor necrosis factor-α antibody limits heart failure in a transgenic model. Circulation. 2001;104:1094–1097
  39. Nishikawa K, Yoshida M, Kusuhara M, Ishigami N, Isoda K, Miyazaki K, et al. Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1. Am J Physiol Heart Circ Physiol. 2006;291:H176–H183
  40. Lang A, Lahav M, Sakhnini E, Barshack I, Fidder HH, Avidan B, et al. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr. 2004;23:1199–1208
  41. Mo SJ, Son EW, Rhee DK, Pyo S. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells. Arch Pharm Res. 2003;26:244–251
  42. Smeets PJ, Teunissen BE, Planavila A, de Vogel-van den Bosch H, Willemsen PH, van der Vusse GJ, et al. Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARα and PPARδ. J Biol Chem. 2008;283:29109–29118
  43. Rossi MA. Pathologic fibrosis and connective tissue matrix in left ventricular hypertrophy due to chronic arterial hypertension in humans. J Hypertens. 1998;16:1031–1041

PII: S0955-2863(09)00243-5

doi: 10.1016/j.jnutbio.2009.11.001

The Journal of Nutritional Biochemistry
Volume 21, Issue 12 , Pages 1238-1250 , December 2010

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