« Previous
Next »
The Journal of Nutritional Biochemistry
Volume 21, Issue 11
, Pages 1120-1126
, November 2010
Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation
References
- . Synthesis of vitamin K-dependent proteins. FASEB J. 1993;7:445–452
- . Characterization of the γ-glutamyl carboxylase. Thromb Haemost. 1997;78:599–604
- . Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr. 1994;72:415–425
- . Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations. J Nutr. 1996;126:537–543
- . Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Biochim Biophys Acta. 1998;1379:69–75
- . Menaquinone-4 accumulation in various tissues after an oral administration of phylloquinone in Wistar rats. J Nutr Sci Vitaminol (Tokyo). 1997;43:133–143
- . Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. J Nutr. 1998;128:220–223
- Conversion of phylloquinone (vitamin K1) into menaquinone-4 (vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice. J Biol Chem. 2008;283:11270–11279
- Novel role of vitamin K in preventing oxidative injury to developing oligodendrocytes and neurons. J Neurosci. 2003;23:5816–5826
- Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation. Clin Cancer Res. 2007;13:2236–2245
- . Novel effect of vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. Neurosci Lett. 2002;323:9–12
- Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Hepatology. 2004;40:243–251
- . Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. J Mol Endocrinol. 2007;39:239–247
- Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochem Biophys Res Commun. 1996;220:515–519
- Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody. Leukemia. 1998;12:1392–1397
- Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia. 2001;15:1111–1117
- . Vitamin K2 selectively induced apoptosis in ovarian TYK-nu and pancreatic MIA PaCa-2 cells out of eight solid tumor cell lines through a mechanism different from geranylgeraniol. J Cancer Res Clin Oncol. 2003;129:1–11
- Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. Int J Oncol. 2003;23:627–632
- . Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures. Eur J Pharmacol. 1994;263:181–185
- . The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain. Bone. 1995;16:179–184
- . Vitamin K2 inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures. Bone. 2000;27:769–776
- . Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcif Tissue Int. 2003;73:78–85
- Effect of vitamin K2 on osteoblast apoptosis: vitamin K2 inhibits apoptotic cell death of human osteoblasts induced by Fas, proteasome inhibitor, etoposide, and staurosporine. J Lab Clin Med. 2000;136:181–193
- Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor, SXR. J Biol Chem. 2003;278:43919–43927
- . Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. J Biol Chem. 2006;281:16927–16934
- . Vitamin K induces osteoblast differentiation through pregnane × receptor-mediated transcriptional control of the Msx2 gene. Mol Cell Biol. 2007;27:7947–7954
- . Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci Biotechnol Biochem. 2006;70:926–932
- Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008;167:313–320
- Vitamin K, circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr. 2008;88:356–363
- . Murine lymphokine-activated killer (LAK) cells: phenotypic characterization of the precursor and effector cells. J Immunol. 1986;15:715–722
- Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats. Biochim Biophys Acta. 2006;1760:1782–1788
- Interleukin 6 production by lipopolysaccharide-stimulated human fibroblasts is potently inhibited by naphthoquinone (vitamin K) compounds. Cytokine. 1995;7:287–290
- . Regulation and function of IKK and IKK-related kinases. Sci STKE. 2006;357:re13
- . Human T-lymphotropic virus type I tax activates I-κB kinase by inhibiting I-κB kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem. 2003;278:1487–1493
- . Protein phosphatase 2Cβ association with the IκB kinase complex is involved in regulating NF-κB activity. J Biol Chem. 2004;279:1739–1746
☆ Funding: This work was partially supported by a grant-in-aid for scientific research from the Japan Society for the Promotion of Science to HS (#1858011, #20380071).
PII: S0955-2863(09)00211-3
doi: 10.1016/j.jnutbio.2009.09.011
© 2010 Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Nutritional Biochemistry
Volume 21, Issue 11
, Pages 1120-1126
, November 2010
