The Journal of Nutritional Biochemistry
Volume 21, Issue 11 , Pages 1089-1098, November 2010

Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells☆

  • Lu Zhu

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Zhongbo Liu

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Zhihui Feng

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Jiejie Hao

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Weili Shen

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • ,
  • Xuesen Li

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Lijuan Sun

      Affiliations

    • College of Physical Education and Health, East China Normal University, Shanghai, China
    • ,
  • Edward Sharman

      Affiliations

    • Department of Neurology, University of California, Irvine, CA 92697, USA
    • ,
  • Ying Wang

      Affiliations

    • DSM Nutritional Products, R and D Human Nutrition and Health, CH-4303 Kaiseraugst, Basel, Switzerland
    • ,
  • Karin Wertz

      Affiliations

    • DSM Nutritional Products, R and D Human Nutrition and Health, CH-4303 Kaiseraugst, Basel, Switzerland
    • ,
  • Peter Weber

      Affiliations

    • DSM Nutritional Products, R and D Human Nutrition and Health, CH-4303 Kaiseraugst, Basel, Switzerland
    • ,
  • Xianglin Shi

      Affiliations

    • Graduate Center for Toxicology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    • ,
  • Jiankang Liu

      Affiliations

    • Graduate Center for Toxicology, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    • Institute of Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University School of Life Science and Technology, Xi'an 710049, China
    • Corresponding Author InformationCorresponding author. Institute of Mitochondrial Biology and Medicine, Xi'an Jiaotong University School of Life Science and Technology, Xi'an, 710049, China. Tel.: +86 29 8266 4232.

Received 18 March 2009; received in revised form 4 September 2009; accepted 14 September 2009. published online 10 February 2010.

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☆ Supported by National Eye Institute, NIH grant EY0160101, 5R01 CA119028-05, R01 CA116697, R01 ES015518, R01 ES015375, a UC Davis Center for Human and Nutrition Pilot Award (CHNR08-318), and DSM Nutritional Products.

PII: S0955-2863(09)00206-X

doi:10.1016/j.jnutbio.2009.09.006

The Journal of Nutritional Biochemistry
Volume 21, Issue 11 , Pages 1089-1098, November 2010

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