The Journal of Nutritional Biochemistry
Volume 21, Issue 8 , Pages 741-748 , August 2010

Green tea polyphenols inhibit cognitive impairment induced by chronic cerebral hypoperfusion via modulating oxidative stress

  • Yan Xu

      Affiliations

    • Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    • ,
  • Jun-jian Zhang

      Affiliations

    • Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 27 62780806; fax: +86 27 67812774.
    • ,
  • Li Xiong

      Affiliations

    • Neuropsychological Research Center, Wuhan University, Wuhan 430071, China
    • ,
  • Lei Zhang

      Affiliations

    • Neuropsychological Research Center, Wuhan University, Wuhan 430071, China
    • ,
  • Dong Sun

      Affiliations

    • Neuropsychological Research Center, Wuhan University, Wuhan 430071, China
    • ,
  • Hui Liu

      Affiliations

    • Neuropsychological Research Center, Wuhan University, Wuhan 430071, China

Received 12 August 2008 ,Revised 24 February 2009 ,Accepted 4 May 2009.

References 

  1. Zlokovic BV. Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev. 2002;54:1553–1559
  2. Royall DR. Alzheimer disease as a vascular disorder: nosological evidence. Stroke. 2002;33:2147–2148
  3. de TJ. Critically attained threshold of cerebral hypoperfusion: can it cause Alzheimer's disease?. Ann N Y Acad Sci. 2000;903:424–436
  4. de TJ. Critical threshold cerebral hypoperfusion causes Alzheimer's disease?. Acta Neuropathol. 1999;98:1–8
  5. Iadecola C. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 2004;5:347–360
  6. Komatani A, Yamaguchi K, Sugai Y, Takanashi T, Kera M, Shinohara M, et al. Assessment of demented patients by dynamic SPECT of inhaled xenon-133. J Nucl Med. 1988;29:1621–1626
  7. Farkas E, Luiten PG. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog Neurobiol. 2001;64:575–611
  8. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev. 2007;54:162–180
  9. Hamel E, Nicolakakis N, Aboulkassim T, Ongali B, Tong XK. Oxidative stress and cerebrovascular dysfunction in mouse models of Alzheimer's disease. Exp Physiol. 2008;93:116–120
  10. Liu C, Wu J, Gu J, Xiong Z, Wang F, Wang J, et al. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav. 2007;86:423–430
  11. Kishido T, Unno K, Yoshida H, Choba D, Fukutomi R, Asahina S, et al. Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain. Biogerontology. 2007;8:423–430
  12. Sutherland BA, Rahman RM, Appleton I. Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem. 2006;17:291–306
  13. Haque AM, Hashimoto M, Katakura M, Tanabe Y, Hara Y, Shido O. Long-term administration of green tea catechins improves spatial cognition learning ability in rats. J Nutr. 2006;136:1043–1047
  14. Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, et al. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury. Brain Res Bull. 2000;53:743–749
  15. Liu HX, Zhang JJ, Zheng P, Zhang Y. Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment. Brain Res Mol Brain Res. 2005;139:169–177
  16. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol. 1978;52:302–310
  17. Imai H, Masayasu H, Dewar D, Graham DI, Macrae IM. Ebselen protects both gray and white matter in a rodent model of focal cerebral ischemia. Stroke. 2001;32:2149–2154
  18. Deguchi K, Hayashi T, Nagotani S, Sehara Y, Zhang H, Tsuchiya A, et al. Reduction of cerebral infarction in rats by biliverdin associated with amelioration of oxidative stress. Brain Res. 2008;1188C:1–8
  19. Otori T, Katsumata T, Muramatsu H, Kashiwagi F, Katayama Y, Terashi A. Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model. Clin Exp Pharmacol Physiol. 2003;30:266–272
  20. Watanabe T, Zhang N, Liu M, Tanaka R, Mizuno Y, Urabe T. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Stroke. 2006;37:1539–1545
  21. He Z, Liao Y, Zheng M, Zeng FD, Guo LJ. Piracetam improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Cell Mol Neurobiol. 2008;28:613–627
  22. Peng Y, Xu S, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J Pharmacol Exp Ther. 2007;321:902–910
  23. Kuriyama S, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, et al. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project 1. Am J Clin Nutr. 2006;83:355–361
  24. Haque AM, Hashimoto M, Katakura M, Hara Y, Shido O. Green tea catechins prevent cognitive deficits caused by Abeta(1–40) in rats. J Nutr Biochem. 2008;19:619–626
  25. Liao Y, Wang R, Tang XC. Centrophenoxine improves chronic cerebral ischemia induced cognitive deficit and neuronal degeneration in rats. Acta Pharmacol Sin. 2004;25:1590–1596
  26. Huang L, He Z, Guo L, Wang H. Improvement of cognitive deficit and neuronal damage in rats with chronic cerebral ischemia via relative long-term inhibition of rho-kinase. Cell Mol Neurobiol. 2008;28:757–768
  27. McCracken E, Valeriani V, Simpson C, Jover T, McCulloch J, Dewar D. The lipid peroxidation by-product 4-hydroxynonenal is toxic to axons and oligodendrocytes. J Cereb Blood Flow Metab. 2000;20:1529–1536
  28. Cui J, Holmes EH, Liu PK. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia. J Neurochem. 1999;73:1164–1174
  29. Ohtaki H, Fujimoto T, Sato T, Kishimoto K, Fujimoto M, Moriya M, et al. Progressive expression of vascular endothelial growth factor (VEGF) and angiogenesis after chronic ischemic hypoperfusion in rat. Acta Neurochir Suppl. 2006;96:283–287
  30. Unno K, Takabayashi F, Kishido T, Oku N. Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10). Exp Gerontol. 2004;39:1027–1034
  31. Srividhya R, Jyothilakshmi V, Arulmathi K, Senthilkumaran V, Kalaiselvi P. Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (−)-epigallocatechin-3-gallate. Int J Dev Neurosci. 2008;26:217–223
  32. Nanjo F, Mori M, Goto K, Hara Y. Radical scavenging activity of tea catechins and their related compounds. Biosci Biotechnol Biochem. 1999;63:1621–1623
  33. Zhu N, Huang TC, Yu Y, LaVoie EJ, Yang CS, Ho CT. Identification of oxidation products of (−)-epigallocatechin gallate and (−)-epigallocatechin with H(2)O(2). J Agric Food Chem. 2000;48:979–981
  34. Rice-Evans C, Miller N. Measurement of the antioxidant status of dietary constituents, low density lipoproteins and plasma. Prostaglandins Leukot Essent Fatty Acids. 1997;57:499–505
  35. Anderson RF, Fisher LJ, Hara Y, Harris T, Mak WB, Melton LD, et al. Green tea catechins partially protect DNA from (•)OH radical-induced strand breaks and base damage through fast chemical repair of DNA radicals. Carcinogenesis. 2001;22:1189–1193
  36. Lee SY, Lee JW, Lee H, Yoo HS, Yun YP, Oh KW, et al. Inhibitory effect of green tea extract on beta-amyloid-induced PC12 cell death by inhibition of the activation of NF-kappaB and ERK/p38 MAP kinase pathway through antioxidant mechanisms. Brain Res Mol Brain Res. 2005;140:45–54
  37. Bastianetto S, Yao ZX, Papadopoulos V, Quirion R. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci. 2006;23:55–64
  38. Kim HK, Kim M, Kim S, Kim M, Chung JH. Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Biosci Biotechnol Biochem. 2004;68:1977–1979

PII: S0955-2863(09)00102-8

doi: 10.1016/j.jnutbio.2009.05.002

The Journal of Nutritional Biochemistry
Volume 21, Issue 8 , Pages 741-748 , August 2010

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