The Journal of Nutritional Biochemistry
Volume 21, Issue 7 , Pages 634-644 , July 2010

Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes

  • Jiejie Hao

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Weili Shen

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • ,
  • Guangli Yu

      Affiliations

    • School of Medicine and Pharmacy, Ocean University of China, China
    • ,
  • Haiqun Jia

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Xuesen Li

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Zhihui Feng

      Affiliations

    • Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    • Graduate School of the Chinese Academy of Sciences, Beijing, China
    • ,
  • Ying Wang

      Affiliations

    • DSM Nutritional Products, R&D Human Nutrition and Health, Basel, Switzerland
    • ,
  • Peter Weber

      Affiliations

    • DSM Nutritional Products, R&D Human Nutrition and Health, Basel, Switzerland
    • ,
  • Karin Wertz

      Affiliations

    • DSM Nutritional Products, R&D Human Nutrition and Health, Basel, Switzerland
    • ,
  • Edward Sharman

      Affiliations

    • Department of Neurology, University of California, Irvine, CA 92697-4292, USA
    • ,
  • Jiankang Liu

      Affiliations

    • Institute of Mitochondrial Biology and Medicine, Department of Biology and Engineering, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi’an Jiaotong University School of Life Science and Technology, Xi’an 710049, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 29 82664232.

Received 13 July 2008 ,Revised 20 March 2009 ,Accepted 27 March 2009.

References 

  1. Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005;39:359–407
  2. Choo HJ, Kim JH, Kwon OB, Lee CS, Mun JY, Han SS, et al. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia. 2006;49:784–791
  3. Hammarstedt A, Jansson PA, Wesslau C, Yang X, Smith U. Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance. Biochem Biophys Res Commun. 2003;301:578–582
  4. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics. 2003;34:267–273
  5. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003;100:8466–8471
  6. Semple RK, Crowley VC, Sewter CP, Laudes M, Christodoulides C, Considine RV, et al. Expression of the thermogenic nuclear hormone receptor coactivator PGC-1alpha is reduced in the adipose tissue of morbidly obese subjects. Int J Obes Relat Metab Disord. 2004;28:176–179
  7. Bogacka I, Xie H, Bray GA, Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes. 2005;54:1392–1399
  8. Lehrke M, Lazar MA. The many faces of PPARgamma. Cell. 2005;123:993–999
  9. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005;307:384–387
  10. McCarty MF. Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. Med Hypotheses. 2005;64:399–407
  11. Fernandez E, Gallus S, La Vecchia C. Nutrition and cancer risk: an overview. The J Br Menopause Soc. 2006;12:139–142
  12. Ordovas JM, Kaput J, Corella D. Nutrition in the genomics era: cardiovascular disease risk and the Mediterranean diet. Mol Nutr Food Res. 2007;51:1293–1299
  13. Ortega RM. Importance of functional foods in the Mediterranean diet. Public Health Nutr. 2006;9:1136–1140
  14. Bendini A, Cerretani L, Carrasco-Pancorbo A, Gomez-Caravaca AM, Segura-Carretero A, Fernandez-Gutierrez A, et al. Phenolic molecules in virgin olive oils: a survey of their sensory properties, health effects, antioxidant activity and analytical methods. An overview of the last decade. Molecules (Basel, Switzerland). 2007;12:1679–1719
  15. Bertelli AA. Wine, research and cardiovascular disease: instructions for use. Atherosclerosis. 2007;195:242–247
  16. Fito M, de la Torre R, Covas MI. Olive oil and oxidative stress. Mol Nutr Food Res. 2007;51:1215–1224
  17. Wahle KW, Caruso D, Ochoa JJ, Quiles JL. Olive oil and modulation of cell signaling in disease prevention. Lipids. 2004;39:1223–1231
  18. Casalino E, Calzaretti G, Sblano C, Landriscina V, Felice Tecce M, Landriscina C. Antioxidant effect of hydroxytyrosol (DPE) and Mn2+ in liver of cadmium-intoxicated rats. Comp Biochem Physiol C Toxicol Pharmacol. 2002;133:625–632
  19. Gordon MH, Paiva-Martins F, Almeida M. Antioxidant activity of hydroxytyrosol acetate compared with that of other olive oil polyphenols. J Agric Food Chem. 2001;49:2480–2485
  20. Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, et al. Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem. 2007;103:2690–2700
  21. Liu J, Ames BN. Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease. Nutr Neurosci. 2005;8:67–89
  22. Shen W, Liu K, Tian C, Yang L, Li X, Ren J, et al. R-alpha-Lipoic acid and acetyl-l-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes. Diabetologia. 2008;51:165–174
  23. Wilson-Fritch L, Burkart A, Bell G, Mendelson K, Leszyk J, Nicoloro S, et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol Cell Biol. 2003;23:1085–1094
  24. Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation. 2005;112:2686–2695
  25. Wilson-Fritch L, Nicoloro S, Chouinard M, Lazar MA, Chui PC, Leszyk J, et al. Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest. 2004;114:1281–1289
  26. Hayakawa T, Noda M, Yasuda K, Yorifuji H, Taniguchi S, Miwa I, et al. Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9. J Biol Chem. 1998;273:20300–20307
  27. Sun L, Luo C, Long J, Wei D, Liu J. Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion. 2006;6:136–142
  28. Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, et al. PGC-1 promotes insulin resistance in liver through PPARα-dependent induction of TRB-3. Nat Med. 2004;10:530–534
  29. Hood DA, Irrcher I, Ljubicic V, Joseph AM. Coordination of metabolic plasticity in skeletal muscle. J Exp Biol. 2006;209:2265–2275
  30. Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. Neurochem Res. 2008;33:194–203
  31. Reznick RM, Shulman GI. The role of AMP-activated protein kinase in mitochondrial biogenesis. J Physiol. 2006;574:33–39
  32. Choi YS, Kim S, Pak YK. Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin Pract. 2001;54(Suppl 2):S3–S9
  33. Nguyen MT, Satoh H, Favelyukis S, Babendure JL, Imamura T, Sbodio JI, et al. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2005;280:35361–35371
  34. Hardie DG. AMP-activated protein kinase: a key system mediating metabolic responses to exercise. Med Sci Sports Exerc. 2004;36:28–34
  35. Park SH, Gammon SR, Knippers JD, Paulsen SR, Rubink DS, Winder WW. Phosphorylation–activity relationships of AMPK and acetyl-CoA carboxylase in muscle. J Appl Physiol. 2002;92:2475–2482
  36. Favero CB, Mandell JW. A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res. 2007;1168:1–10
  37. Armstrong JS. Mitochondrial medicine: pharmacological targeting of mitochondria in disease. Br J Pharmacol. 2007;151:1154–1165
  38. Fosslien E. Mitochondrial medicine—molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci. 2001;31:25–67
  39. Larsson NG, Luft R. Revolution in mitochondrial medicine. FEBS Letters. 1999;455:199–202
  40. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006;127:397–408
  41. Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science. 2002;296:349–352
  42. Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science. 2003;299:896–899
  43. Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WGT, Schlattner U, et al. Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem. 2004;279:43940–43951
  44. Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc C, Itani SI, et al. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 2002;99:16309–16313
  45. Berger JP, Petro AE, Macnaul KL, Kelly LJ, Zhang BB, Richards K, et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Mol Endocrinol. 2003;17:662–676

PII: S0955-2863(09)00081-3

doi: 10.1016/j.jnutbio.2009.03.012

The Journal of Nutritional Biochemistry
Volume 21, Issue 7 , Pages 634-644 , July 2010

Article Tools

* Image Usage & Resolution