The Journal of Nutritional Biochemistry
Volume 21, Issue 7 , Pages 589-597 , July 2010

α-, γ- and δ-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells

  • Shannon R. Wells

      Affiliations

    • LSUHSC-S Molecular and Cellular Physiology, Shreveport, LA 71130-3932, USA
    • ,
  • Merilyn H. Jennings

      Affiliations

    • LSUHSC-S Molecular and Cellular Physiology, Shreveport, LA 71130-3932, USA
    • ,
  • Courtney Rome

      Affiliations

    • LSUHSC-S Molecular and Cellular Physiology, Shreveport, LA 71130-3932, USA
    • ,
  • Vicky Hadjivassiliou

      Affiliations

    • Yasoo Health Ltd, Prodromou and Demetrakopoulou 2, 1090 Nicosia, Cyprus
    • ,
  • Konstantinos A. Papas

      Affiliations

    • Yasoo Health Inc, P.O Box 3608, Johnson City, TN 37604-6024, USA
    • ,
  • Jonathon S. Alexander

      Affiliations

    • LSUHSC-S Molecular and Cellular Physiology, Shreveport, LA 71130-3932, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 318 675 4151; fax: +1 318 675 4156.

Received 16 February 2009 ,Revised 10 March 2009 ,Accepted 17 March 2009.

References 

  1. Burton GW, Traber MG. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Ann Rev of Nutr. 1990;10:357–382
  2. Ozer NK, Sirikci O, Taha S, San T, Moser U, Azzi A. Effect of vitamin E and probucol on dietary cholesterol-induced atherosclerosis in rabbits. Free Radic Biol Med. 1998;24(2):226–233
  3. Saeed RW, Peng T, Metz CN. Ascorbic acid blocks the growth inhibitory effect of tumor necrosis factor-α on endothelial cells. Exp Biol Med. 2003;228:855–865
  4. Williamson KS, Gabbita SP, Mou S, West M, Pye QN, Markesbery WR, et al. The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide. 2002;6(2):221–227
  5. Erl W, Weber C, Wardemann C, Weber PC. α-Tocopherol succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-κB mobilization. Am J Physiol. 1997;273:H634–H640
  6. Ahn KS, Sethi G, Krishnan K, Aggarwal BB. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem. 2007 Jan 5;282(1):809–820
  7. Shah SJ, Sylvester PW. Gamma-tocotrienol inhibits neoplastic mammary epithelial cell proliferation by decreasing Akt and nuclear factor kappaB activity. Exp Biol Med (Maywood). 2005;230(4):235–241
  8. Breyer I, Azzi A. Differential inhibition by α- and β-tocopherol of human erythroleukemia cell adhesion: role of integrins. Free Radic Biol Med. 2001;30(12):1381–1389
  9. Azzi A, Gysin R, Kempna P, Munteanu A, Negis Y, Villacorta L, et al. Vitamin E mediates cell signaling and regulation of gene expression. Ann N Y Acad Sci. 2004;1034:86–95
  10. Marui N, Offermann MK, Swerlick R, Kunsch C, Rosen CA, Ahmad M, et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest. 1993;92:1866–1874
  11. Azzi A, Stocker A. Vitamin E: non-antioxidant roles. Prog Lipid Res. 2000;39(3):231–255
  12. Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov. 2007;6(4):273–286
  13. Goebel S, Huang M, Davis WC, Jennings M, Siahaan TJ, Alexander JS, et al. VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2006;290(4):G648–G654[Electronic publication 2005 Nov 17]
  14. Costa C, Incio J, Soares R. Angiogenesis and chronic inflammation: cause or consequence?. Angiogenesis. 2007;10(3):149–166
  15. Yoshida N, Manabe H, Terasawa Y, Nishimura H, Enjo F, Nishino H, et al. Alpha-tocopherol protects against monocyte Mac-1 (CD11b/CD18) expression and Mac-1-dependent adhesion to endothelial cells induced by oxidized low-density lipoprotein. Biofactors. 2000;11(4):221–233
  16. Yoshida N, Yoshikawa T, Manabe H, Terasawa Y, Kondo M, Noguchi N, et al. Inhibitory effects of vitamin E on endothelial-dependent adhesive interactions with leukocytes induced by oxidized low density lipoprotein. Biofactors. 2000;13(1-4):279–288
  17. Yoshikawa T, Yoshida N, Manabe H, Terasawa Y, Takemura T, Kondo M. Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells. J Leukoc Biol. 1999;65(6):757–763
  18. Miyazawa T, Tsuzuki T, Nakagawa K, Igarashi M. Antiangiogenic potency of vitamin E. Ann N Y Acad Sci. 2004;1031:401–404
  19. Tang FY, Meydani M. Green tea catechins and vitamin E inhibit angiogenesis of human microvascular endothelial cells through suppression of IL-8 production. Nutr Cancer. 2001;41(1-2):119–125
  20. Schindler R, Mentlein R. Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial factor from human tumor cells. J Nutr. 2006;136(6):1477–1482
  21. McCormick CC, Parker RS. The cytotoxicity of vitamin E is both vitamer- and cell-specific and involves a selectable trait. J Nutr. 2004;134:3335–3342
  22. Ando T, Jordan P, Wang Y, Itoh M, Joh T, Sasaki M, et al. MAdCAM-1 expression and regulation in murine colonic endothelial cells in vitro. Inflamm Bowel Dis. 2005;11(3):258–264
  23. Azzi A. Molecular mechanism of α-tocopherol action. Free Radic Biol Med. 2007;43:16–21
  24. Vaule H, Leonard SW, Traber MG. Vitamin E delivery to human skin: studies using deuterated α-tocopherol measured by APCI LC-MS. Free Radic Biol Med. 2003;36:456–463
  25. Ford ES, Schleicher RL, Mokdad AH, Ajani UA, Liu S. Distribution of serum concentrations of alpha-tocopherol and gamma-tocopherol in the US population. Am J Clin Nutr. 2006;84:375–383
  26. Traber MG. How much vitamin E ?…Just enough!. Am J Clin Nutr. 2006;84:959–960
  27. Stocker R. Vitamin E. Novartis Found Symp. 2007;282:77–87[ discussion 87-92, 212-8]
  28. Jiang Q, Christen S, Shigenaga MK, Ames BN. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001;74:714–722
  29. Facchini FS, Humphreys MH, DoNascimento CA, Abbasi F, Reaven GM. Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Am J Clin Nutr. 2000;72:776–779
  30. Hatoum OA, Heidemann J, Binion DG. The intestinal microvasculature as a therapeutic target in inflammatory bowel disease. Ann N Y Acad Sci. 2006;1072:78–97
  31. Kevil CG, Chidlow JH, Langston W, Greer JJ, Ostanin D, Abdelbagi M, et al. Differential angiogenic regulation of experimental colitis. Am J Pathol. 2006;169(6):2014–2030
  32. Danese S, Sans M, Spencer DM, Beck I, Donate F, Plunkett ML, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut. 2007;56(6):855–862[Electronic publication 2006 Dec 14]
  33. Huang HY, Appel LJ. Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma and delta-tocopherol in humans. J Nutr. 2003;133:3137–3140
  34. Devaraj S, Adams-Huet B, Fuller CJ, Jialal I. Dose-response comparison of RRR-α-tocopherol and all-racemic-α-tocopherol on LDL oxidation. Arterioscler Thromb Vasc Biol. 1997;17:2273–2279
  35. Navarra T, Turco SD, Papa A, Battaglia D, Lazzerini G, Basta G. Lack of effect of α-tocopherol on in vitro angiogenesis. Microvasc Res. 2006;72:12–19
  36. Sasaki M, Jordan P, Joh T, Itoh M, Jenkins M, Pavlick K, et al. Melatonin reduces TNF-α induced expression of MAdCAM-1 via inhibition of NF-kappaB. BMC Gastroenterol. 2002;2:9
  37. Azzi A, Breyer I, Feher M, Ricciarelli R, Stocker A, Zimmer S, et al. Nonantioxidant functions of a-tocopherol in smooth muscle cells. J Nutr. 2001;131:378S–381S
  38. Ushio-Fukai M, Nakamura Y. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett. 2008;[Electronic publication ahead of print]
  39. Serini G, Napione L, Bussolino F. Integrins team up with tyrosine kinase receptors and plexins to control angiogenesis. Curr Opin Hematol. 2008;15(3):235–242
  40. Soriano A, Salas A, Salas A, Sans M, Gironella M, Elena M, et al. VCAM-1, but not ICAM-1 or MAdCAM-1, immunoblockade ameliorates DSS-induced colitis in mice. Lab Invest. 2000;80(10):1541–1551
  41. Reiter E, Azzi A, Zingg JM. Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells. Biofactors. 2007;30(2):67–77
  42. Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002;29(6 Suppl 16):15–18[Review]
  43. Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell. 2002;1(3):219–227[Review]
  44. Tammela T, Enholm B, Alitalo K, Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc Res. 2005;65(3):550–563
  45. Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium. J Exp Med. 2006;203(12):2763–2777
  46. Sawa Y, Sugimoto Y, Ueki T, Ishikawa H, Sato A, Nagato T, et al. Effects of TNF-alpha on leukocyte adhesion molecule expressions in cultured human lymphatic endothelium. J Histochem Cytochem. 2007;55(2):721–733
  47. Krieglstein CF, Granger DN. Adhesion molecules and their role in vascular disease. Am J Hypertens. 2001;14(6 Pt 2):44S–54S[Review]
  48. Saban MR, Memet S, Jackson DG, Ash J, Roig AA, Israel A, et al. Visualization of lymphatic vessels through NF-kappaB activity. Blood. 2004;104(10):3228–3230
  49. Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, Garcia A, et al. Isoforms of Vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J Immunol. 2009;182:4395–4405
  50. Maulik N, Das DK. Redox signaling in vascular angiogenesis. Free Radic Biol Med. 2002;33(8):1047–1060

☆ These studies were supported by funding through Yasoo Health Inc., a grant from the United Nations (UNESCO) and NIH DK43785.

PII: S0955-2863(09)00073-4

doi: 10.1016/j.jnutbio.2009.03.006

The Journal of Nutritional Biochemistry
Volume 21, Issue 7 , Pages 589-597 , July 2010

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