The Journal of Nutritional Biochemistry
Volume 21, Issue 4 , Pages 332-337 , April 2010

Differential effects of conjugated linoleic acid isomers in insulin-resistant female C57Bl/6J mice

Received 28 August 2008 ,Revised 5 January 2009 ,Accepted 9 January 2009.

References 

  1. Wasan KM, Looije NA. Emerging pharmacological approaches to the treatment of obesity. J Pharm Pharm Sci. 2005;8:259–271
  2. Racette SB, Deusinger SS, Deusinger RH. Obesity: overview of prevalence, etiology, and treatment. Phys Ther. 2003;83:276–288
  3. DeLany JP, Blohm F, Truett AA, Scimeca JA, West DB. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol. 1999;276:R1172–R1179
  4. Smedman A, Vessby B. Conjugated linoleic acid supplementation in humans—metabolic effects. Lipids. 2001;36:773–781
  5. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun. 1998;244:678–682
  6. Rudel LL. Atherosclerosis and conjugated linoleic acid. Br J Nutr. 1999;81:177–179
  7. Yu Y, Correll PH, Vanden Heuvel JP. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. Biochim Biophys Acta. 2002;1581:89–99
  8. Tsuboyama-Kasaoka N, Miyazaki H, Kasaoka S, Ezaki O. Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. J Nutr. 2003;133:1793–1799
  9. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, et al. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes. 2000;49:1534–1542
  10. Poirier H, Rouault C, Clement L, et al. Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia. 2005;48:1059–1065
  11. Clement L, Poirier H, Niot I, et al. Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res. 2002;43:1400–1409
  12. Degrace P, Demizieux L, Gresti J, Chardigny JM, Sebedio JL, Clouet P. Hepatic steatosis is not due to impaired fatty acid oxidation capacities in C57BL/6J mice fed the conjugated trans-10,cis-12-isomer of linoleic acid. J Nutr. 2004;134:861–867
  13. Rahman SM, Wang Y, Yotsumoto H, et al. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition. 2001;17:385–390
  14. Sakono M, Yuji K, Miyanaga F, et al. Combined effects of dietary conjugated linoleic acid and sesamin triacylglycerol and ketone body production in rat liver. J Nutr Sci Vitaminol (Tokyo). 2002;48:405–409
  15. Nagao K, Inoue N, Wang YM, Yanagita T. Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem Biophys Res Commun. 2003;310:562–566
  16. Park Y, Storkson JM, Albright KJ, Liu W, Pariza MW. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 1999;34:235–241
  17. Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res. 2001;29:392–396
  18. Bauman DE, Barbano DM, Dwyer DA, Griinari JM. Technical note: production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. J Dairy Sci. 2000;83:2422–2425
  19. Eulitz K, Yurawecz MP, Sehat N, et al. Preparation, separation, and confirmation of the eight geometrical cis/trans conjugated linoleic acid isomers 8,10- through 11,13-18:2. Lipids. 1999;34:873–877
  20. Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17:789–810
  21. Bhattacharya A, Rahman MM, McCarter R, O'Shea M, Fernandes G. Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice. Lipids. 2006;41:437–444
  22. Bhattacharya A, Rahman MM, Sun D, et al. The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice. J Nutr. 2005;135:1124–1130
  23. Winzell MS, Ahren B. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes. 2004;53(Suppl 3):S215–S219
  24. Surwit RS, Kuhn CM, Cochrane C, McCubbin JA, Feinglos MN. Diet-induced type II diabetes in C57BL/6J mice. Diabetes. 1988;37:1163–1167
  25. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G. Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res. 2003;18:1206–1216
  26. Bhattacharya A, Rahman M, Banu J, et al. Inhibition of osteoporosis in autoimmune disease prone MRL/Mpj-Fas(lpr) mice by N-3 fatty acids. J Am Coll Nutr. 2005;24:200–209
  27. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  28. Wallace TM, Levy JC, Matthews DR. An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study. Diabet Med. 2004;21:568–576
  29. Perseghin G, Caumo A, Caloni M, Testolin G, Luzi L. Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. J Clin Endocrinol Metab. 2001;86:4776–4781
  30. Silveira MB, Carraro R, Monereo S, Tebar J. Conjugated linoleic acid (CLA) and obesity. Public Health Nutr. 2007;10:1181–1186
  31. http://www.nutraingredients-usa.com/Industry/CLA-achieves-US-approval-for-use-in-foods.
  32. Ryder JW, Portocarrero CP, Song XM, et al. Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression. Diabetes. 2001;50:1149–1157
  33. Park Y, Albright KJ, Liu W, Storkson JM, Cook ME, Pariza MW. Effect of conjugated linoleic acid on body composition in mice. Lipids. 1997;32:853–858
  34. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids. 1999;34:243–248
  35. West DB, Delany JP, Camet PM, Blohm F, Truett AA, Scimeca J. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol. 1998;275:R667–R672
  36. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516–1521
  37. Medina EA, Horn WF, Keim NL, et al. Conjugated linoleic acid supplementation in humans: effects on circulating leptin concentrations and appetite. Lipids. 2000;35:783–788
  38. Moloney F, Toomey S, Noone E, et al. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via antiinflammatory effects in white adipose tissue. Diabetes. 2007;56:574–582
  39. Despres JP, Nadeau A, Tremblay A, et al. Role of deep abdominal fat in the association between regional adipose tissue distribution and glucose tolerance in obese women. Diabetes. 1989;38:304–309
  40. Kissebah AH. Insulin resistance in visceral obesity. Int J Obes. 1991;15(Suppl 2):109–115
  41. Field CJ, Ryan EA, Thomson AB, Clandinin MT. Diet fat composition alters membrane phospholipid composition, insulin binding, and glucose metabolism in adipocytes from control and diabetic animals. J Biol Chem. 1990;265:11143–11150
  42. Liu S, Baracos VE, Quinney HA, Clandinin MT. Dietary omega-3 and polyunsaturated fatty acids modify fatty acyl composition and insulin binding in skeletal-muscle sarcolemma. Biochem J. 1994;299(Pt 3):831–837
  43. Staiger H, Haring HU. Adipocytokines: fat-derived humoral mediators of metabolic homeostasis. Exp Clin Endocrinol Diabetes. 2005;113:67–79
  44. Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1995;1:1155–1161
  45. Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941–946
  46. Yanagita T, Wang YM, Nagao K, Ujino Y, Inoue N. Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. J Agric Food Chem. 2005;53:9629–9633
  47. Yamasaki M, Ikeda A, Oji M, et al. Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets. Nutrition. 2003;19:30–35
  48. Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem Biophys Res Commun. 2004;323:679–684
  49. Akahoshi A, Goto Y, Murao K, et al. Conjugated linoleic acid reduces body fats and cytokine levels of mice. Biosci Biotechnol Biochem. 2002;66:916–920
  50. Kelley DS, Warren JM, Simon VA, Bartolini G, Mackey BE, Erickson KL. Similar effects of c9,t11-CLA and t10,c12-CLA on immune cell functions in mice. Lipids. 2002;37:725–728
  51. Kelley DS, Simon VA, Taylor PC, et al. Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Lipids. 2001;36:669–674
  52. Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J Nutr. 2000;130:1548–1554
  53. Brodie AE, Manning VA, Ferguson KR, Jewell DE, Hu CY. Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. J Nutr. 1999;129:602–606
  54. Ide T. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes. 2005;54:412–423

☆ Funding sources: Supported by NIH grant R21 AG027562.

PII: S0955-2863(09)00015-1

doi: 10.1016/j.jnutbio.2009.01.006

The Journal of Nutritional Biochemistry
Volume 21, Issue 4 , Pages 332-337 , April 2010

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