The Journal of Nutritional Biochemistry
Volume 21, Issue 4 , Pages 285-289 , April 2010

The association between adherence to the Mediterranean diet and adiponectin levels among healthy adults: the ATTICA study

  • Elizabeth Fragopoulou

      Affiliations

    • Department of Science Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 9549305; fax: +30 210 9577050.
  • ,
  • Demosthenes B. Panagiotakos

      Affiliations

    • Department of Science Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece
  • ,
  • Christos Pitsavos

      Affiliations

    • First Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, Greece
  • ,
  • Metaxia Tampourlou

      Affiliations

    • Department of Science Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece
  • ,
  • Christina Chrysohoou

      Affiliations

    • First Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, Greece
  • ,
  • Tzortzis Nomikos

      Affiliations

    • Department of Science Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece
  • ,
  • Smaragdi Antonopoulou

      Affiliations

    • Department of Science Nutrition-Dietetics, Harokopio University, 176 71 Athens, Greece
  • ,
  • Christodoulos Stefanadis

      Affiliations

    • First Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, Greece

Received 29 July 2008 ,Revised 5 December 2008 ,Accepted 22 December 2008.

References 

  1. Trichopoulou A, Lagiou P. Healthy traditional Mediterranean diet: an expression of culture, history and lifestyle. Nutr Rev. 1997;55:383–389
  2. Keys A, Menotti A, Karvonen MJ, et al. The diet and 15-year death rate in the Seven Countries Study. Am J Epidemiol. 1986;124:903–905
  3. De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Mamelle N. Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation. 1999;99:779–785
  4. Panagiotakos DB, Pitsavos C, Polychronopoulos E, Chrysohoou C, Zampelas A, Trichopoulou A. Can a Mediterranean diet moderate the development and clinical progression of coronary heart disease? A systematic review. Med Sci Monit. 2004;10:RA193–RA198
  5. Panagiotakos DB, Pitsavos CH, Chrysohoou C, et al. Status and Management of Hypertension, in Greece; the role of the adoption of Mediterranean Diet: the ATTICA study. J Hypertens. 2003;21:1483–1489
  6. Schröder H, Marrugat J, Vila J, Covas MI, Elosua R. Adherence to the traditional Mediterranean diet is inversely associated with body mass index and obesity in a Spanish population. J Nutr. 2004;34:3355–3361
  7. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. J Am Coll Cardiol. 2004;44:152–158
  8. Esposito K, Ciotola M, Giugliano F. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004;292:1440–1446
  9. Pitsavos C, Panagiotakos DB, Tzima N, et al. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Am J Clin Nutr. 2005;82:694–699
  10. Ahima RS. Adipose tissue as an endocrine organ. Obesity. 2006;14:242S–249S
  11. Oh DK, Ciaraldi T, Henry RR. Adiponectin in health and disease. Diabetes Obes Metab. 2007;9:282–289
  12. Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in Type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000;20:1595–1599
  13. Mohan V, Deepa R, Pradeepa R, et al. Association of low adiponectin levels with the metabolic syndrome — the Chennai Urban Rural Epidemiology Study (CURES-4). Metabolism. 2005;54:476–481
  14. Shetty GK, Economides PA, Horton ES, Mantzoros CS, Veves A. Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care. 2004;27:2450–2457
  15. Haque WA, Shimomura I, Matsuzawa Y, Garg A. Serum adiponectin and leptin levels in patients with lipodystrophies. J Clin Endocrinol Metab. 2002;87:2395
  16. Han SH, Quon MJ, Kim JA, Koh KK. Adiponectin and cardiovascular disease: response to therapeutic interventions. J Am Coll Cardiol. 2007;49:531–538
  17. Monzillo LU, Hamdy O, Horton ES, et al. Effect of lifestyle modification on adipokines levels in obese subjects with insulin resistance. Obes Res. 2003;11:1048–1054
  18. Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA. 2003;289(14):1799–1804
  19. Mantzoros CS, Williams CJ, Manson JE, Meigs JB, Hu FB. Adherence to the Mediterranean dietary pattern is positively associated with plasma adiponectin concentrations in diabetic women. Am J Clin Nutr. 2006;84:328–335
  20. Pitsavos C, Panagiotakos DB, Chrysohoou C, Stefanadis C. Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study. BMC Public Health. 2003;3:32
  21. Katsouyanni K, Rimm EB, Gnardellis C, Trichopoulos D, Polychronopoulos E, Trichopoulou A. Reproducibility and relative validity of an extensive semi-quantitative food frequency questionnaire using dietary records and biochemical markers among Greek schoolteachers. Int J Epidemiol. 1999;26:S118–S127
  22. Supreme Scientific Health Council, Ministry of Health and Welfare of Greece . Dietary guidelines for adults in Greece. Arch Hellenic Med. 1999;16:516–524
  23. Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med. 2007;44:335–340
  24. Demopoulos CA, Karantonis HC, Antonopoulou S. Platelet activating factor — a molecular link between atherosclerosis theories. Eur J Lipid Sci Technol. 2003;105:705–716
  25. Kris-Etherton PM, Hecker KD, Bonanome A, et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 2002;113:S71–S88
  26. Nishida M, Funahashi T, Shimomura I. Pathophysiological significance of adiponectin. Med Mol Morphol. 2007;40:55–67
  27. Qi L, Hu FB. Dietary glycemic load, whole grains, and systemic inflammation in diabetes: the epidemiological evidence. Curr Opin Lipidol. 2007;18:3–8
  28. Itoh M, Suganami T, Satoh N, et al. Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects. Arterioscler Thromb Vasc Biol. 2007;27:1918–1925
  29. Paniagua JA, Gallego de la Sacristana A, Romero I, et al. Monounsaturated fat-rich diet prevents central body fat distribution and decreases postprandial adiponectin expression induced by a carbohydrate-rich diet in insulin-resistant subjects. Diabetes Care. 2007;30:1717–1723
  30. Shimada K, Kawarabayashi T, Tanaka A, et al. Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease. Diabetes Res Clin Pract. 2004;65(3):227–234
  31. Pischon T, Girman CJ, Rifai N, et al. Association between dietary factors and plasma adiponectin concentrations in men. Am J Clin Nutr. 2005;81:780–786
  32. Sierksma A, Patel H, Ouchi N, et al. Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care. 2004;27:184–189
  33. Kotani K, Sakane N, Saiga K, Sano Y, Kurozawa Y. Lifestyle-related determinants and serum adiponectin concentrations in a general population of Japanese females. Arch Med Res. 2007;38(8):887–890
  34. Kotani K, Sakane N, Saiga K, et al. Serum adiponectin levels and lifestyle factors in Japanese men. Heart Vessels. 2007;22(5):291–296
  35. Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257:79–83
  36. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003;46:459–469
  37. Yamamoto Y, Hirose H, Saito I, et al. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci. 2002;103:137–142
  38. Laughlin GA, Barrett-Connor E, May S. Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones. Int J Obes. 2007;31:457–465
  39. Adamczak M, Rzepka E, Chudek J, Wiecek A. Ageing and plasma adiponectin concentration in apparently healthy males and females. Clin Endocrinol. 2005;62:114–118
  40. Takefuji S, Yatsuya H, Tamakoshi K, et al. Smoking status and adiponectin in healthy Japanese men and women. Prev Med. 2007;45:471–475
  41. Tsukinoki R, Morimoto K, Nakayama K. Association between lifestyle factors and plasma adiponectin levels in Japanese men. Lipids Health Dis. 2005;4:27–34
  42. Iwashima Y, Katsuya T, Ishikawa K, et al. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension. 2004;43:1318–1323

 The ATTICA Study is funded by research grants from the Hellenic Society of Cardiology (Grant 1, 2002).

PII: S0955-2863(09)00006-0

doi: 10.1016/j.jnutbio.2008.12.013

The Journal of Nutritional Biochemistry
Volume 21, Issue 4 , Pages 285-289 , April 2010