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The Journal of Nutritional Biochemistry
Volume 21, Issue 3
, Pages 237-246
, March 2010
Zinc supplementation partially prevents renal pathological changes in diabetic rats
References
- . Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des. 2005;11:2279–2299
- . Molecular targets of diabetic cardiovascular complications. Curr Drug Targets. 2005;6:487–494
- . Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med. 2006;40:183–192
- . Renal handling of zinc in insulin-dependent diabetes mellitus patients. Biometals. 2001;14:75–80
- Effect of end-stage renal disease and diabetes on zinc and copper status. Biol Trace Elem Res. 2006;112:1–12
- . Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care. 2007;30:523–528
- . Zinc and the diabetic heart. Biometals. 2005;18:325–332
- Induction of metallothionein in proximal tubular cells by zinc and its potential as an endogenous antioxidant. Kidney Blood Press Res. 2005;28:127–133
- Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation. 2006;113:544–554
- . Comparative toxicity of cadmium-metallothionein and cadmium chloride on mouse kidney. Arch Pathol. 1975;99:192–197
- . Renal metallothionein and platinum levels in diabetic and nondiabetic rats injected with cisplatin. Proc Soc Exp Biol Med. 1991;197:285–289
- . The susceptibility of spontaneously diabetic mice to cadmium-metallothionein nephrotoxicity. Toxicology. 1994;89:81–90
- . Endothelin-1-mediated alteration of metallothionein and trace metals in the liver and kidneys of chronically diabetic rats. Int J Exp Diabetes Res. 2002;3:193–198
- . Renal metallothionein metabolism after a reduction of renal mass. II. Effect of zinc pretreatment on the renal toxicity and intrarenal accumulation of inorganic mercury. Toxicology. 1992;71:103–117
- . Induction of metallothionein-I protects glomeruli from superoxide-mediated increase in albumin permeability. Exp Biol Med (Maywood). 2002;227:26–31
- . Protective role of zinc-metallothionein (Zn-MT) in iron nitrilotriacetate (Fe-NTA)-induced renal oxidative damage. Redox Rep. 2003;8:163–167
- . Fluvastatin prevents nephropathy likely through suppression of connective tissue growth factor-mediated extracellular matrix accumulation. Exp Mol Pathol. 2004;76:66–75
- Reversal of glomerulosclerosis after high-dose enalapril treatment in subtotally nephrectomized rats. J Am Soc Nephrol. 2003;14:2833–2842
- Cell lines with extended in vitro growth potential from human renal proximal tubule: characterization, response to inducers, and comparison with established cell lines. J Lab Clin Med. 1997;129:318–329
- . Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway. Diabetes. 2002;51:1938–1948
- Role of ERK1/2 and p38 mitogen-activated protein kinases in the regulation of thrombospondin-1 by TGF-beta1 in rat proximal tubular cells and mouse fibroblasts. J Am Soc Nephrol. 2005;16:899–904
- Involvement of extracellular signal-regulated kinase and p38 in human diabetic nephropathy. Am J Kidney Dis. 2005;45:54–65
- ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cells. J Cell Physiol. 2007;211:88–100
- . Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action. J Am Soc Nephrol. 2006;17:2999–3012
- . Plasminogen activator inhibitor-1 and diabetic nephropathy. Nephrology (Carlton). 2005;10(Suppl):S11–S13
- . Effect of plasminogen activator inhibitor-1 in diabetes mellitus and cardiovascular disease. Am J Med. 2003;115(Suppl 8A):62S–68S
- . Plasminogen activator inhibitor Type 1 is a potential target in renal fibrogenesis. Kidney Int. 2000;58:1841–1850
- . Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am J Pathol. 2004;165:2033–2043
- Connective tissue growth factor expressed in tubular epithelium plays a pivotal role in renal fibrogenesis. J Am Soc Nephrol. 2005;16:133–143
- . Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of Type 1 and Type 2 diabetes. Faseb J. 2007;
- . Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes. 2008;57:1446–1454
- Inhibition of superoxide generation and associated nitrosative damage is involved in metallothionein prevention of diabetic cardiomyopathy. Diabetes. 2005;54:1829–1837
- . Diabetic cardiomyopathy and its prevention by metallothionein: experimental evidence, possible mechanisms and clinical implications. Curr Med Chem. 2007;14:2193–2203
- . Zinc-metallothionein protects from DNA damage induced by radiation better than glutathione and copper- or cadmium-metallothioneins. Toxicol Lett. 2003;136:193–198
- . Metallothionein inhibits peroxynitrite-induced DNA and lipoprotein damage. J Biol Chem. 2000;275:38957–38960
- Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. Am J Pathol. 2005;167:17–26
- . Overexpression of metallothionein reduces diabetic cardiomyopathy. Diabetes. 2002;51:174–181
- . Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats. J Dermatol Sci. 2007;45:193–201
- . Sex difference in cardiomyocyte function in normal and metallothionein transgenic mice: the effect of diabetes mellitus. J Appl Physiol. 2006;100:1638–1646
- Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. J Am Coll Cardiol. 2006;48:1688–1697
- . Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol. Metabolism. 2007;56:1256–1264
- A functional polymorphism in the manganese superoxide dismutase gene and diabetic nephropathy. Diabetes. 2007;56:265–269
- . Overexpression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes. 2001;50:2114–2125
- Catalase overexpression attenuates angiotensinogen expression and apoptosis in diabetic mice. Kidney Int. 2007;71:912–923
- . Effect of vitamin E and vitamin C supplementation on antioxidative state and renal glomerular basement membrane thickness in diabetic kidney. Nephron Exp Nephrol. 2003;95:e134–e143
- . Antioxidants attenuate high glucose-induced hypertrophic growth in renal tubular epithelial cells. Am J Physiol Renal Physiol. 2007;
- . Potential antioxidant effects of zinc and chromium supplementation in people with Type 2 diabetes mellitus. J Am Coll Nutr. 2001;20:212–218
- Renal changes of streptozotocin-induced diabetic rats fed a low-zinc diet. Ren Fail. 1995;17:349–363
- . Metallothionein induction in human CNS in vitro: neuroprotection from ionizing radiation. Int J Radiat Biol. 2000;76:1009–1017
- . Zinc- or cadmium-pre-induced metallothionein protects human central nervous system cells and astrocytes from radiation-induced apoptosis. Toxicol Lett. 2004;146:217–226
- . Podocyte-Specific Overexpression of the Antioxidant Metallothionein Reduces Diabetic Nephropathy. J Am Soc Nephrol. 2008;
- . Zinc fluxes and zinc transporter genes in chronic diseases. Mutat Res. 2007;622:84–93
- . A role for metallothionein in the pathogenesis of diabetes and its cardiovascular complications. Mol Genet Metab. 2008;94:1–3
- . Role of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus. Med Hypotheses. 2005;65:887–892
- . Comparison of the effects of vitamins and/or mineral supplementation on glomerular and tubular dysfunction in Type 2 diabetes. Diabetes Care. 2005;28:2458–2464
- Effects of melatonin and zinc on lipid profile and renal function in Type 2 diabetic patients poorly controlled with metformin. J Pineal Res. 2006;41:189–193
- . Effect of zinc supplementation on microalbuminuria in patients with Type 2 diabetes: a double blind, randomized, placebo-controlled, cross-over trial. Rev Diabet Stud. 2008;5:102–109
- . Serum zinc levels in diabetic patients and effect of zinc supplementation on glycemic control of Type 2 diabetics. Saudi Med J. 2006;27:344–350
- . Oral zinc therapy in diabetic neuropathy. J Assoc Physicians India. 1998;46:939–942
☆ Financial support: The study was supported in part by grants from American Diabetes Association (02-07-JF-02; 05-07-02, to L. Cai), from Juvenile Diabetes Research Foundation, International (5-2006-382) and from the Chinese-American Research Institute for Diabetic Complications, Wenzhou Medical College to L. Cai and X.K. Li.
PII: S0955-2863(08)00268-4
doi: 10.1016/j.jnutbio.2008.12.010
© 2010 Elsevier Inc. All rights reserved.
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The Journal of Nutritional Biochemistry
Volume 21, Issue 3
, Pages 237-246
, March 2010
