The Journal of Nutritional Biochemistry
Volume 21, Issue 3 , Pages 196-205, March 2010

Cocoa flavonoids up-regulate antioxidant enzyme activity via the ERK1/2 pathway to protect against oxidative stress-induced apoptosis in HepG2 cells☆

  • María Ángeles Martín

      Affiliations

    • Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (formerly Instituto del Frío), CSIC, Ciudad Universitaria, 28040 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Tel.: +34 91 544 56 07; fax: +34 91 549 36 27.
    • ,
  • Ana Belén Granado Serrano

      Affiliations

    • Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (formerly Instituto del Frío), CSIC, Ciudad Universitaria, 28040 Madrid, Spain
    • ,
  • Sonia Ramos

      Affiliations

    • Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (formerly Instituto del Frío), CSIC, Ciudad Universitaria, 28040 Madrid, Spain
    • ,
  • María Izquierdo Pulido

      Affiliations

    • Department of Nutrition and Food Science, Facultad de Farmacia, Universidad de Barcelona, 28028 Barcelona, Spain
    • ,
  • Laura Bravo

      Affiliations

    • Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (formerly Instituto del Frío), CSIC, Ciudad Universitaria, 28040 Madrid, Spain
    • ,
  • Luis Goya

      Affiliations

    • Department of Metabolism and Nutrition, Instituto de Ciencia y Tecnología de los Alimentos y Nutrición (formerly Instituto del Frío), CSIC, Ciudad Universitaria, 28040 Madrid, Spain

Received 17 June 2008; received in revised form 17 October 2008; accepted 30 October 2008. published online 06 February 2009.

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☆ This work was supported by grant no. AGL2004-302, grant no. AGL2007-64042/ALI and project no. CSD 2007-00063 from Programa Consolider-Ingenio of the Spanish Ministry of Science and Innovation (CICYT), as well as CDTI project no. 20060013 with the food company Nutrexpa. A.B. Granado-Serrano is a predoctoral fellow of the Spanish Ministry of Education and Science.

PII: S0955-2863(08)00248-9

doi:10.1016/j.jnutbio.2008.10.009

The Journal of Nutritional Biochemistry
Volume 21, Issue 3 , Pages 196-205, March 2010

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