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The Journal of Nutritional Biochemistry
Volume 21, Issue 2
, Pages 107-115
, February 2010
Moderate doses of conjugated linoleic acid isomers mix contribute to lowering body fat content maintaining insulin sensitivity and a noninflammatory pattern in adipose tissue in mice
References
- . Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 2007;85:1203–1211
- . Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids. 2002;37:1019–1025
- Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007;97:550–560
- Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr. 2004;79:1118–1125
- . Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr. 2003;57:595–603
- Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr. 2005;59:508–517
- . Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sports Exerc. 2004;36:814–820
- . The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr. 2002;88:243–251
- . The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr. 2003;133:257S–260S
- . Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr. 2004;80:887–895
- . Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci (Lond). 2000;99:511–516
- . Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care. 2002;25:1516–1521
- . Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia. 2004;47:1016–1019
- . Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr. 2004;80:279–283
- Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes. 2000;49:1534–1542
- Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res. 2002;43:1400–1409
- . Conjugated linoleic acids: are they beneficial or detrimental to health?. Prog Lipid Res. 2004;43:553–587
- . Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue. Diabetes. 2006;55:1634–1641
- . A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29:e45
- . Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol. 1999;276:R1172–R1179
- . Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse. Biochimie. 2005;87:73–79
- Hyperinsulinaemia triggered by dietary conjugated linoleic acid is associated with a decrease in leptin and adiponectin plasma levels and pancreatic beta cell hyperplasia in the mouse. Diabetologia. 2005;48:1059–1065
- . Trans-10,cis-12 conjugated linoleic acid reduces triglyceride content while differentially affecting peroxisome proliferator activated receptor gamma2 and aP2 expression in 3T3-L1 preadipocytes. Lipids. 2001;36:1223–1232
- . Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17:789–810
- . Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J Nutr. 2001;131:2067–2068
- Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821–1830
- . Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond). 2005;29:146–150
- . Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab. 2005;90:2282–2289
- . Regulation of monocyte chemoattractant protein 1 (MCP-1) release by explants of human visceral adipose tissue. Int J Obes (Lond). 2005;29:1299–1307
- . Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm. 2006;74:443–477
- . Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112:1796–1808
- Isomer-dependent metabolic effects of conjugated linoleic acid: insights from molecular markers sterol regulatory element-binding protein-1c and LXRalpha. Diabetes. 2002;51:2037–2044
- . Leptin. Annu Rev Physiol. 2000;62:413–437
- . Role of resistin in obesity, insulin resistance and type II diabetes. Clin Sci (Lond). 2005;109:243–256
- . Leptin as a proinflammatory cytokine. Contrib Nephrol. 2006;151:151–164
- . Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond). 2006;110:267–278
- . Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev. 2005;6:13–21
- Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. J Clin Endocrinol Metab. 2004;89:2697–2703
- . Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J Lipid Res. 2008;49:98–106
- . Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007;117:175–184
- . Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56:16–23
- . Macrophage-secreted factors impair human adipogenesis: involvement of proinflammatory state in preadipocytes. Endocrinology. 2007;148:868–877
- Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes. 2005;54:2277–2286
- Antidiabetic effects of cis-9,trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes. 2007;56:574–582
- . Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med. 2007;262:408–414
- MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116:1494–1505
- Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem. 2006;281:26602–26614
☆ This work was supported by grants from the Spanish Government (AGL2004-07496, AGL2006-04887). Our laboratory is a member of the European Research Network of Excellence NuGO (The European Nutrigenomics Organization, European Union Contract No. FP6-506360). P. Parra is a recipient of a fellowship from the Spanish Government. CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative from ISCIII.
PII: S0955-2863(08)00246-5
doi: 10.1016/j.jnutbio.2008.10.010
© 2010 Elsevier Inc. All rights reserved.
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The Journal of Nutritional Biochemistry
Volume 21, Issue 2
, Pages 107-115
, February 2010
