The Journal of Nutritional Biochemistry
Volume 21, Issue 3 , Pages 180-187 , March 2010

Gender affects liver desaturase expression in a rat model of n−3 fatty acid repletion

  • Audrey Extier

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France
    • Corresponding Author InformationCorresponding author. INRA-NuRéLiCe, Domaine de Vilvert, 78350 Jouy-en-Josas, France. Tel.: +33 1 34 65 23 14; fax: +33 1 34 65 23 11.
    • ,
  • Bénédicte Langelier

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France
    • ,
  • Marie-Hélène Perruchot

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France
    • ,
  • Philippe Guesnet

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France
    • ,
  • Paul P. Van Veldhoven

      Affiliations

    • Molecular Cell Biology, K.U. Leuven-Campus Gasthuisberg, LIPIT, BE-3000 Leuven, Belgium
    • ,
  • Monique Lavialle

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France
    • ,
  • Jean-Marc Alessandri

      Affiliations

    • Unit of Lipid Nutrition and Regulation of Brain Functions, NuRéLiCe, UR909, INRA, F 78352 Jouy-en-Josas, France

Received 8 July 2008 ,Revised 22 September 2008 ,Accepted 16 October 2008.

References 

  1. Sprecher H, Luthria DL, Mohammed BS, Baykousheva SP. Reevaluation of the pathways for the biosynthesis of polyunsaturated fatty acids. J Lipid Res. 1995;36:2471–2477
  2. Ferdinandusse S, Denis S, Mooijer PAW, Zhang Z, Reddy JK, Spector AA, et al. Identification of the peroxisomal β-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. J Lipid Res. 2001;42:1987–1995
  3. Alessandri JM, Guesnet P, Vancassel S, Astorg P, Denis I, Langelier B, et al. Polyunsaturated fatty acids in the nervous system, evolution of concepts and nutritional implications throughout life. Reprod Nutr Dev. 2004;44:509–538
  4. McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. Am J Clin Nutr. 2005;82:281–295
  5. Igarashi M, DeMar JC, Ma K, Chang L, Bell JM, Rapoport SI. Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. J Lipid Res. 2007;48:152–164
  6. Rapoport SI, Rao JS, Igarashi M. Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot Essent Fatty Acids. 2007;77:251–261
  7. Moore SA. Cerebral endothelium and astrocytes cooperate in supplying docosahexaenoic acid to neurons. Adv Exp Med Biol. 1993;331:229–233
  8. Moore SA. Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. J Mol Neurosci. 2001;16:195–200
  9. Williard DE, Harmon SD, Kaduce TL, Preuss M, Moore SA, Robbins MEC, et al. Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes. J Lipid Res. 2001;42:1368–1376
  10. Burdge GC, Jones AE, Wootton SA. Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr. 2002;88:355–363
  11. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002;88:411–420
  12. Burdge GC, Calder PC. Conversion of α-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod Nutr Dev. 2005;45:581–597
  13. Giltay EJ, Gooren LJG, Toorians AWFT, Katan MB, Zock PL. Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr. 2004;80:1167–1174
  14. Giltay EJ, Duschek EJ, Katan MB, Zock PL, Neele SJ, Netelenbos JC. Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol. 2004;182:399–408
  15. Burdge GC, Slater-Jefferies JL, Grant RA, Chung AL, West AL, Lillycrop KA, et al. Sex, but not maternal protein or folic acid intake, determines the fatty acid composition of hepatic phospholipids, but not of triacylglycerol, in adult rats. Prostaglandins Leukot Essent Fatty Acids. 2007;78:73–79
  16. Noh SK, Koo SI, Jeon IJ. Estradiol replacement in ovariectomized rats increases the hepatic concentration and biliary secretion of α-tocopherol and polyunsaturated fatty acids. J Nutr Biochem. 1999;10:110–117
  17. Langelier B, Alessandri JM, Perruchot MH, Guesnet P, Lavialle M. Changes of the transcriptional and fatty acid profiles in response to n-3 fatty acids in SH-SY5Y neuroblastoma cells. Lipids. 2005;40:719–728
  18. Alessandri JM, Poumès-Ballihaut C, Langelier B, Perruchot MH, Raguénez G, Lavialle M, et al. Incorporation of docosahexaenoic acid into nerve membrane phospholipids, bridging the gap between animals and cultured cells. Am J Clin Nutr. 2003;78:702–710
  19. Dieuaide-Noubhani M, Novikov DK, Baumgart E, Vanhooren JCT, Fransen M, Goethals M, et al. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and trihydroxycoprostanic acids are metabolized by separate multifunctional proteins. Eur J Biochem. 1996;240:660–666
  20. Childs CE, Romeu-Nadal M, Burdge GC, Calder PC. Gender differences in the n-3 fatty acid content of tissues. Proc Nutr Soc. 2008;67:19–27
  21. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to palmitic, palmitoleic, stearic and oleic acids in men and women. Prostaglandins Leukot Essent Fatty Acids. 2003;69:283–290
  22. Alessandri JM, Extier A, Langelier B, Perruchot MH, Heberden C, Guesnet P, et al. Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. Lipids. 2008;43:19–28
  23. Igarashi M, DeMar JC, Ma K, Chang L, Bell JM, Rapoport SI. Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. J Lipid Res. 2007;48:1150–1158
  24. Igarashi M, Ma K, Chang L, Bell JM, Rapoport SI. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. J Lipid Res. 2007;48:2463–2470
  25. Smit EN, Fokkema MR, Boersma ER, Muskiet FAJ. Higher erythrocyte 22:6n--3 and 22:5n-6, and lower 22:5n-3 suggest higher delta-4 desaturation capacity in women of childbearing age. Br J Nutr. 2003;89:739–740
  26. Cunnane SC, Ryan MA, Nadeau CR, Bazinet RP, Musa-Veloso K, McCloy U. Why is carbon from some polyunsaturates extensively recycled into lipid synthesis?. Lipids. 2003;38:477–484
  27. Marra CA, De Alaniz MJ, Brenner RR. Effect of various steroids on the biosynthesis of arachidonic acid in isolated hepatocytes and HTC cells. Lipids. 1988;23:1053–1058
  28. Gonzalez S, Nervi AM, Peluffo RO. Effects of estradiol and environmental temperature changes on rat liver delta 6 microsomal desaturase activity. Lipids. 1986;21:440–443
  29. Leonard AE, Kelder B, Bobik EG, Chuang L, Parker-Barnes JM, Thurmond JM, et al. cDNA cloning and characterization of human delta-5 desaturase involved in the biosynthesis of arachidonic acid. Biochem J. 2000;347:719–724
  30. Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, Poulton R, et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci. 2007;104:18860–18865
  31. Cho HP, Nakamura M, Clarke SD. Cloning, expression, and fatty acid regulation of the human delta-5 desaturase. J Biol Chem. 2000;274:37335–37339
  32. Jalouli M, Carlsson L, Améen C, Lindén D, Ljungberg A, Michalik L, et al. Sex difference in hepatic peroxisome proliferator-activated receptor expression: influence of pituitary and gonadal hormones. Endocrinology. 2003;144:101–109
  33. Ciana P, Biserni A, Tatangelo L, Tiveron C, Sciarroni AF, Ottobrini L, et al. A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. Mol Endocrinol. 2007;21:388–400
  34. Améen C, Lindén D, Larsson BM, Mode A, Holmäng A, Oscarsson J. Effects of gender and GH secretory pattern on sterol regulatory element-binding protein-1c and its target genes in rat liver. Am J Physiol Endocrinol Metab. 2004;287:E1039–E1048
  35. Nakamura MT, Cheon Y, Li Y, Nara TY. Mechanisms of regulation of gene expression by fatty acids. Lipids. 2004;39:1077–1083

☆ Disclosure statement: Audrey Extier, Bénédicte Langelier, Marie-Hélène Perruchot, Philippe Guesnet, Paul P. Van Veldhoven, Monique Lavialle and Jean-Marc Alessandri declare no conflict of interest.

PII: S0955-2863(08)00244-1

doi: 10.1016/j.jnutbio.2008.10.008

The Journal of Nutritional Biochemistry
Volume 21, Issue 3 , Pages 180-187 , March 2010

Article Tools

* Image Usage & Resolution