The Journal of Nutritional Biochemistry
Volume 21, Issue 1 , Pages 14-22 , January 2010

Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats

  • Anastasia Z. Kalea

      Affiliations

    • Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA
    • ,
  • Kateryna Clark

      Affiliations

    • Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA
    • ,
  • Dale A. Schuschke

      Affiliations

    • Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    • ,
  • Aleksandra S. Kristo

      Affiliations

    • Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA
    • ,
  • Dorothy J. Klimis-Zacas

      Affiliations

    • Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA
    • Corresponding Author InformationCorresponding author. Department of Food Science and Human Nutrition, College of Natural Sciences, Forestry and Agriculture, University of Maine, Orono, ME 04469, USA. Tel.: +1 207 581 3124; fax: +1 207 581 1636.

Received 10 June 2008 ,Revised 22 September 2008 ,Accepted 23 September 2008.

References 

  1. Rissanen TH, Voutilainen S, Virtanen JK, Venho B, Vanharanta M, Mursu J, et al. Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. J Nutr. 2003;133:199–204
  2. Liu S, Manson JE, Lee IM, Cole SR, Hennekens CH, Willett WC, et al. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr. 2000;72:922–928
  3. Visioli F, Borsani L, Galli C. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc Res. 2000;47:419–425
  4. Prior R, Cao G, Martin A, Sofic E, McEwen J, O'Brien C, et al. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity and variety of Vaccinium species. J Agric Food Chem. 1998;46:2686–2693
  5. Duarte J, Perez-Palencia R, Vargas F, Angeles Ocete M, Perez-Vizcaino F, Zarzuelo A, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol. 2001;133:117–124
  6. Nakamura Y, Matsumoto H, Todoki K. Endothelium-dependent vasorelaxation induced by black currant concentrate in rat thoracic aorta. Jpn J Pharmacol. 2002;89:29–35
  7. Andriambeloson E, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, et al. Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr. 1998;128:2324–2333
  8. Fitzpatrick D, Hirschfield S, Ricci T, Jantzen P, Coffey R. Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol. 1995;26:90–95
  9. Mizutani K, Ikeda K, Kawai Y, Yamori Y. Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol. 1999;45:95–106
  10. Diebolt M, Bucher B, Andriantsitohaina R. Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension. 2001;38:159–165
  11. Bernátová I, Pechánová O, Babál P, Kyselá S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol. 2002;282:H942–H948
  12. Norton C, Kalea AZ, Harris PD, Klimis-Zacas D. Wild blueberry-rich diets affect the contractile machinery of the vascular smooth muscle in the Sprague–Dawley rat. J Med Food. 2005;8:8–13
  13. Kalea AZ, Lamari FN, Theocharis AD, Cordopatis P, Schuschke DA, Karamanos NK, et al. Wild blueberry (Vaccinium angustifolium) consumption affects the composition and structure of glycosaminoglycans in Sprague-Dawley rat aorta. J Nutr Biochem. 2006;17:109–116
  14. Verma S, Buchanan MR, Anderson TJ. Endothelial function testing as a biomarker of vascular disease. Circulation. 2003;108:2054–2059
  15. Arnal JF, Dinh-Xuan AT, Pueyo M, Darblade B, Rami J. Endothelium-derived nitric oxide and vascular physiology and pathology. Cellular and Molecular Life Sciences (CMLS). 1999;55:1078–1087
  16. Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87:840–844
  17. Salvemini D, Currie M, Mollace V. Nitric oxide-mediated cyclooxygenase activation. J Clin Invest. 1996;97:2562–2568
  18. Lüscher T, Vanhoutte P. The endothelium modulator of cardiovascular function. Boca Raton (Fla): CRC Press; 1990;
  19. Vanhoutte PM, Feletou M, Taddei S. Endothelium-dependent contractions in hypertension. Br J Pharmacol. 2005;144:449–458
  20. Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension. 1999;33:1353–1358
  21. Zalba G, Beaumont FJ, San Jose G, Fortuno A, Fortuno MA, Diez J. Is the balance between nitric oxide and superoxide altered in spontaneously hypertensive rats with endothelial dysfunction?. Nephrol Dial Transplant. 2001;16:2–5
  22. Yang D, Feletou M, Boulanger CM, Wu HF, Levens N, Zhang JN, et al. Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol. 2002;136:104–110
  23. Cuzzocrea S, Mazzon E, Dugo L, Di Paola R, Caputi AP, Salvemini D. Superoxide: a key player in hypertension. FASEB J. 2004;18:94–101
  24. Luscher TF, Vanhoutte PM. Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Hypertension. 1986;8:344–348
  25. Machha A, MR M. Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol. 2005;46:36–40
  26. Kalea AZ, Harris PD, Klimis-Zacas DJ. Dietary manganese suppresses α1 adrenergic receptor-mediated vascular contraction. J Nutr Biochem. 2005;16:44–49
  27. Kalea AZ, Schuschke DA, Harris PD, Klimis-Zacas DJ. Cyclo-oxygenase inhibition restores the attenuated vasodilation in manganese-deficient rat aorta. J Nutr. 2006;136:2302–2307
  28. Kawabe T, Harris PD, Zakaria REL, Garrison NR. Sepsis alters vessel contraction by adrenoceptor-induced nitric oxide and prostanoid. J Surg Res. 2003;110:352–359
  29. Kalea A, Norton C, Harris P, Klimis-Zacas D. Whole wild blueberries suppress α1 adrenergic agonist induced contraction in rat aorta. FASEB J. 2003;
  30. Nyborg NC, Bevan JA. Increased alpha-adrenergic receptor affinity in resistance vessels from hypertensive rats. Hypertension. 1988;11:635–638
  31. Villalobos-Molina R, Lopez-Guerrero JJ, Ibarra M. Functional evidence of [alpha]1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats. Br J Pharmacol. 1999;126:1534–1536
  32. Akpaffiong M, Taylor A. Antihypertensive and vasodilator actions of antioxidants in spontaneously hypertensive rats. Am J Hypertens. 1998;11:1450–1460
  33. Cappelli-Bigazzi M, Rubattu S, Battaglia C, Russo R, Enea I, Ambrosio G, et al. Effects of high-cholesterol and atherogenic diets on vascular relaxation in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol. 1997;273:H647–H654
  34. White RM, Rivera CO, Davison CB. Differential contribution of endothelial function to vascular reactivity in conduit and resistance arteries from deoxycorticosterone-salt hypertensive rats. Hypertension. 1996;27:1245–1253
  35. Koga T, Takata Y, Kobayashi K, Takishita S, Yamashita Y, Fujishima M. Age and hypertension promote endothelium-dependent contractions to acetylcholine in the aorta of the rat. Hypertension. 1989;14:542–548
  36. Girouard H, de Champlain J. Acute and chronic effects of free radicals on [alpha]1-adrenergic-induced vasoconstriction in mesenteric beds of spontaneously hypertensive rats. J Hypertens. 2005;23:807–814
  37. Davidge ST, Baker PN, McLaughlin MK, Roberts JM. Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ Res. 1995;77:274–283
  38. Mombouli J, Nakashima M, Hamra M, Vanhoutte P. Endothelium-dependent relaxation and hyperpolarization evoked by bradykinin in canine coronary arteries. Br J Pharmacol. 1999;117:413–418
  39. Diederich D, Yang ZH, Buhler FR, Luscher TF. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway. Am J Physiol Heart Circ Physiol. 1990;258:H445–H451
  40. Ge T, Hughes H, Junquero DC, Wu KK, Vanhoutte PM, Boulanger CM. Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. Circ Res. 1995;76:1003–1010
  41. Radaelli A, Mircoli L, Mori I, Mancia G, Ferrari AU. Nitric oxide–dependent vasodilation in young spontaneously hypertensive rats. Hypertension. 1998;32:735–739
  42. Sawada Y, Sakamaki T, Nakamura T, Sato K, Ono Z, Murata K. Release of nitric oxide in response to acetylcholine is unaltered in spontaneously hypertensive rats. J Hypertens. 1994;12:745–750
  43. Chou TC, Yen MH, Li CY, Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension. 1998;31:643–648
  44. Carneado J, Alvarez de Sotomayor M, Perez-Guerrero C, Jimenez L, Herrera M, Pamies E, et al. Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect. J Hypertens. 2002;20:429–437
  45. Grunfeld S, Hamilton CA, Mesaros S, McClain SW, Dominiczak AF, Bohr DF, et al. Role of superoxide in the depressed nitric oxide production by the endothelium of genetically hypertensive rats. Hypertension. 1995;26:854–857
  46. Katusic Z. Superoxide anion and endothelial regulation of arterial tone. Free Radic Biol Med. 1996;20:443–448
  47. Marnett LJ. Cyclooxygenase mechanisms. Curr Opin Chem Biol. 2000;4:545–552
  48. Cosentino , Patton S, d'Uscio L, Werner E, Werner-Felmayer G, Moreau P, et al. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest. 1998;101:1530–1537
  49. Newaz M, Yousefipour Z, Nawal N, Adeeb N. Nitric oxide synthase activity in blood vessels of spontaneously hypertensive rats: antioxidant protection by gamma-tocotrienol. J Physiol Pharmacol. 2003;54:319–327
  50. Serraino I, Dugo L, Dugo P, Mondello L, Mazzon E, Dugo C, et al. Protective effects of cyaniding-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Life Sci. 2003;73:1097–1114

☆ This work was supported in part by a grant from the Wild Blueberry Commission of Maine, the Wild blueberry Association of North America, the USDA/CSREES, and the Regular Research Faculty Fund of the University of Maine to Dr. Dorothy Klimis-Zacas (Maine Agriculture and Forestry Experiment Station, Scientific Contribution, #2980).

PII: S0955-2863(08)00214-3

doi: 10.1016/j.jnutbio.2008.09.005

The Journal of Nutritional Biochemistry
Volume 21, Issue 1 , Pages 14-22 , January 2010

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