The Journal of Nutritional Biochemistry
Volume 20, Issue 12 , Pages 948-955 , December 2009

Anxiolytic effects of short- and long-term administration of cacao mass on rat elevated T-maze test

  • Takashi Yamada

      Affiliations

    • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
  • ,
  • Yasushi Yamada

      Affiliations

    • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
  • ,
  • Yasuyo Okano

      Affiliations

    • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
  • ,
  • Takehiko Terashima

      Affiliations

    • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
    • School of Health Promotional Science, University of Hamamatsu, Hamamatsu 431-2102, Japan
  • ,
  • Hidehiko Yokogoshi

      Affiliations

    • Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 54 264 5558; fax: +81 54 263 7079.

Received 6 February 2008 ,Revised 11 August 2008 ,Accepted 14 August 2008.

References 

  1. Tang M, Kuribara H, Falk JL. Anxiolytic effect of caffeine and caffeine-clonazepan interaction: evaluation by NaCl solution intake. Pharmacol Biochem Behav. 1989;32:773–776
  2. Chen SW, Xin Q, Kong WX, Min L, Li JF. Anxiolytic-like effect of succinic acid in mice. Life Sci. 2003;73:3257–3264
  3. Lund TD, Lephart ED. Dietary soy phytoestrogens produce anxiolytic effects in the elevated plus-maze. Brain Res. 2001;913:180–184
  4. Bechtholt AJ, Hill TE, Lucki I. Anxiolytic effect of serotonin depletion in the novelty-induced hypophagia test. Psychopharmacology. 2007;190:531–540
  5. Ottley C. Food and mood. Nurs Stand. 2000;15:46–52
  6. Teixeira RC, Zangrossi H, Graeff FG. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav. 2000;65:571–576
  7. Sanger DJ, Perrault G, Morel E, Joly D, Zivkovic B. Animal models of anxiety and the development of novel anxiolytic drugs. Prog Neuro-Psychopharmacol Biol Psychiatry. 1991;15:205–212
  8. Rodgers RJ, Nikulina EM, Cole JC. Dopamine D1 and D2 receptor ligands modulate the behavior of mice in the elevated plus-maze. Pharmacol Biochem Behav. 1994;49:985–995
  9. File SE, Hyde JRG. Can social interaction be used to measure anxiety?. Br J Pharmacol. 1987;62:19–24
  10. Greaff FG, Guimaraes FS, De Andrade TG, Deakin JF. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav. 1996;54:129–141
  11. Handley SL, Mithani S. Effects of alpha2-adrenoceptor agonists and antagonists in a maze-exploration model of fear-motivated behavior. Naunyn Schmiedebergs Arch Pharmacol. 1984;327:1–5
  12. Blows WT. Neurotransmitters of the brain: serotonin, noradrenaline (norepinephirune), and dopamine. J Neurosci Nurs. 2000;32:234–238
  13. Stahl S, Briley M. Understanding pain in depression. Hum Psychopharmacol. 2004;19:9–13
  14. Brunello N, Blier P, Judd LL, Mendlewicz J, Nelson CJ, Souery D, et al. Noradrenaline in mood and anxiety disorders: basic and clinical studies. Int Clin Psychopharmacol. 2003;18:191–202
  15. Fricchione G, Stefano GB. Placebo neural systems: nitric oxide, morphine and the dopamine brain reward and motivation circuitries. Med Sci Monit. 2005;11:54–65
  16. Friedel RO. Dopamine dysfunction in borderline personality disorder: a hypothesis. Neuropsychopharmacology. 2004;29:1029–1039
  17. Nutt DJ, Bell CJ, Malizia AL. Brain mechanisms of social anxiety disorder. J Clin Psychiatry. 1998;59:4–11
  18. Gutman DA, Owens MJ. Serotonin and norepinephrine transporter binding profile of SSRIs. Essent Psychopharmacol. 2006;7:35–41
  19. Dishman RK. Brain monoamines, exercise, and behavioral stress: animal models. Med Sci Sports Exerc. 1997;29:63–74
  20. Olson EB, Morgan WP. Rat brain monoamine levels related to behavioral assessment. Life Sci. 1982;30:2095–2100
  21. Yacoubi EM, Bouali S, Popa D, Naudon L, Leroux-Nicollet I, Haman M, et al. Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. Proc Natl Acad Sci U S A. 2003;100:6227–6232
  22. Okuyama S, Sawasaki E, Yokogoshi H. Conductor compounds of phenylpentane in Mycoleptodonoides aitchisonii myceliem enhance the release of dopamine from rat brain striatum slices. Nutr Neurosci. 2004;7:107–111
  23. Okuyama S, Lam NV, Hatakeyama T, Terashima T, Yamagata K, Yokogoshi H. Mycoleptodonoides aitchisonii affects brain nerve growth factor concentration in newborn rats. Nutr Neurosci. 2004;7:341–349
  24. Graeff FG, Viana MB, Tomaz C. The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam. Braz J Med Biol Res. 1993;26:67–70
  25. Knoll AT, Meloni EG, Thomas JB, Carroll FI, Carlezon WA. Anxiolytic-like effects of k-opioid receptor antagonists in models of unlearned and learned fear in rats. J Pharmacol Exp Ther. 2007;323:838–845
  26. Gur E, Lerer B, van de Kar LD, Newman ME. Chronic rTMS induces subsensitivity of post-synaptic 5-HT1A receptors in rat hypothalamus. Int J Neuropsychopharmacol. 2004;7:335–340
  27. Ballenger JC. Overview of different pharmacotherapies for attaining remission in generalized anxiety disorder. J Clin Psychiatry. 2001;62:11–19
  28. Stein DJ, Westenberg HG, Liebowitz MR. Social anxiety disorder and generalized anxiety disorder: serotonergic and dopaminergic neurocircuitry. J Clin Psychiatry. 2002;63:12–19
  29. Graeff FG, Viana MG, Mora PO. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev. 1997;21:791–799
  30. Michener W, Rozin P. Pharmacological versus sensory factors in the satiation of chocolate craving. Physiol Behav. 1994;56:419–422
  31. Tomaso E, Beltramo M, Piome D. Brain cannabinoids in chocolate. Nature. 1996;382:677–678
  32. Carney JM, Cao W, Logan L, Rennert OM, Seale TW. Differential antagonism of the behavioral depressant and hypothermic effects of 5’-(n-ethylcarboxamide) adenosine by theobromine. Parmacol Biochem Behav. 1986;25:769–773
  33. Gobbi G, Bambico FR, Mangieri R, Bortolato M, Compolongo P, Solinas M, et al. Antidepressant-like activity and modulation of brain monoaminergic. Proc Natl Acad Sci U S A. 2005;102:18620–18625
  34. Navarro M, Hernandez E, Munoz RM, del Arco I, Villanua MA, Carrera MR, et al. Acute administration of the CB1 cannabinoid receptor antagonist SR 141716A induces anxiety-like responses in the rat. Neuroreport. 1997;20:491–496
  35. Dourish CT. Behavioral effects of acute and chronic beta-phenyletylamine administration in the rat: evidence for the involvement of 5-hydroxytryptamine. Neuropharmacology. 1981;20:1067–1072
  36. Szabo A, Billett E, Turner J. Phenylethylamine, a possible link to the antidepressant effects of exercise?. Br J Sports Med. 2001;35:342–343
  37. Moreira FA, Aguiar DC, Guimaraes FS. Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray. Neuropharmacology. 2007;52:958–965
  38. Stark T, Bareuther S, Hofmann T. Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments. J Agric food Chem. 2006;54:5530–5539
  39. Di Marzo V, Sepe N, De Petrocellis L, Berger A, Crozier G, Fride E, et al. Trick or treat from food endocannabinoids. Nature. 1998;396:636–637
  40. Carvalho-Freitas MI, Costa M. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol Pharm Bull. 2002;25:1629–1633
  41. Orosco M, Rouch C, Beslot F, Feurte S, Regnault A, Dauge V. Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat. Behav Brain Res. 2004;148:1–10

 This work was supported in part by grants for scientific research from Shizuoka Prefecture, and the 21st Century COE program from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PII: S0955-2863(08)00192-7

doi: 10.1016/j.jnutbio.2008.08.007

The Journal of Nutritional Biochemistry
Volume 20, Issue 12 , Pages 948-955 , December 2009