The Journal of Nutritional Biochemistry
Volume 20, Issue 10 , Pages 823-830 , October 2009

Mitochondrial and sarcoplasmic protein changes in hearts from copper-deficient rats: up-regulation of PGC-1α transcript and protein as a cause for mitochondrial biogenesis in copper deficiency

Received 1 July 2008 ,Revised 1 August 2008 ,Accepted 5 August 2008.

References 

  1. Elsherif L, Ortines RV, Saari JT, Kang YJ. Congestive heart failure in copper-deficient mice. Exp Biol Med. 2003;228:811–817
  2. Liao Z, Allred J, Keen CL, McCune SA, Rucker RB, Medeiros DM. Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts. Comp Biochem Physiol. 1995;111B:61–67
  3. Lehman JJ, Kelly DP. Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. Heart Fail Rev. 2002;7:175–185
  4. Neubauer S. The failing heart — an engine out of fuel: mechanisms of disease. N Engl J Med. 2007;356:1140–1151
  5. Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation. 2007;115:909–917
  6. American Institute of Nutrition . Second report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies. J Nutr. 1980;107:1726
  7. Jin JK, Whittaker R, Glassy MS, Barlow SB, Gottlieb RA, Glembotski CC. Localization of phosphorylated alpha B-crystallin to heart mitochondria during ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2008;294:H337–H344
  8. Dohke T, Wada A, Isono T, Fujii M, Yamamoto T, Tsutamoto T, et al. Proteomic analysis reveals significant alternations of cardiac small heat shock protein expression in congestive heart failure. J Card Fail. 2006;12:77–84
  9. Keller A, Rouzeau JD, Farhadian F, Wisnewsky C, Marotte F, Lamandé N, et al. Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy. Am J Physiol. 1995;269(6 Pt 2):H1843–H1851
  10. Dzeja PP, Redfield MM, Burnett JC, Terzic A. Failing energetics in failing hearts. Curr Cardiol Rep. 2000;2:212–217
  11. Ramana KV, Willis MS, White MD, Horton JW, DiMaio JM, Srivastava D, et al. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation. 2006;114:1838–1846
  12. Iwata K, Nishinaka T, Matsuno K, Kakehi T, Katsuyama M, Ibi M, et al. The activity of aldose reductase is elevated in diabetic mouse heart. J Pharmacol Sci. 2007;103:408–416
  13. Lygate CA, Fischer A, Sebag-Montefiore L, Wallis J, ten Hove M, Neubauer S. The creatine kinase energy transport system in the failing mouse heart. J Mol Cell Cardiol. 2007;42:1129–1136
  14. Chao JCJ, Medeiros DM, Altschuld RA, Hohl CM. Cardiac nucleotide levels and mitochondrial respiration in copper-deficient rats. Comp Biochem Physiol. 1993;104A:163–168
  15. Liz MA, Gomes CM, Saraiva MJ, Sousa MM. ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity. J Lipid Res. 2007;248:2385–2395
  16. Singh N, Medeiros DM. Liver fatty acid profiles and trace element concentrations in heart and liver of copper deficient rats. Biological Trace Element Research. 1984;6:423–429
  17. Chao CJJ, Medeiros DM, Davidson J, Shiry L. Decreased levels of ATP synthase and cytochrome c oxidase subunit peptide from hearts of copper-deficient rats are not altered by the administration of dimethyl sulfoxide. J Nutr. 1994;124:789–803
  18. Mao S, Leone TC, Kelly DP, Medeiros DM. Mitochondrial transcription factor A is increased but expression of ATP synthase β subunit and medium-chain acyl-CoA dehydrogenase genes are decreased in hearts from copper-deficient rats. J Nutr. 2000;130:2143–2150
  19. Mao S, Medeiros DM. Nuclear respiratory factors 1 and 2 are upregulated in hearts from copper-deficient rats. Biol Trace El Res. 2001;83:57–68
  20. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92:829–839
  21. Finck BN, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. Circulation. 2007;115:2540–2548
  22. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mortha V, et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999;98:115–124
  23. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000;106:847–856
  24. Gleyzer N, Vercauteren K, Scarpulla RC. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol. 2005;25:1354–1366
  25. Saari JT, Wold LE, Duan J, Ren J, Carlson HL, Bode AM, et al. Cardiac nitric oxide synthases are elevated in dietary copper deficiency. J Nutr Biochem. 2007;18:443–448
  26. Klaahsen D, Ricklefs K, Medeiros DM. Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation, and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkb1. J Nutr Biochem. 2007;18:719–726
  27. Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonella C, Sciorata C, et al. Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science. 2003;299:896–899
  28. Nisoli E, Carruba MO. Nitric oxide and mitochondrial biogenesis. J Cell Sci. 2006;119:2855–2862
  29. Medeiros DM, Shiry L, Samelman T. Cardiac nuclear encoded cytochrome c oxidase subunits are decreased with copper restriction but not from iron restriction: gene expression, protein synthesis and heat shock protein aspects. Comp Biochem Physiol. 1997;117A:77–87

☆ Publication contribution number from K-State Research and Extension is 09-016-J. Supported in part from funds for USDA multi-state project number W1002: “Nutrient Bioavailability: Phytonutrients and Beyond”. Proteinomic analysis was made possible by a Kansas State University Targeted Excellence Award entitled “Functional Genomics Consortium”. National Science Foundation Research Instrumentation grant number 0521587 funded a portion of the Biotechnology Core and Proteinomics facility.

PII: S0955-2863(08)00177-0

doi: 10.1016/j.jnutbio.2008.08.001

The Journal of Nutritional Biochemistry
Volume 20, Issue 10 , Pages 823-830 , October 2009

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