The Journal of Nutritional Biochemistry
Volume 20, Issue 10 , Pages 806-815, October 2009

Identification of a novel agonist of peroxisome proliferator-activated receptors α and γ that may contribute to the anti-diabetic activity of guggulipid in Lepob/Lepob mice☆☆☆

  • Claire L. Cornick

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • ,
  • Barbara H. Strongitharm

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Gary Sassano

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Christopher Rawlins

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Andrew E. Mayes

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Alison N. Joseph

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Jacqueline O'Dowd

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • ,
  • Claire Stocker

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • ,
  • Ed Wargent

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • ,
  • Michael A. Cawthorne

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • ,
  • A. Louise Brown

      Affiliations

    • Biosciences Division, Unilever Research, Colworth Laboratory, Sharnbrook, MK44 1LQ Bedfordshire, UK
    • ,
  • Jonathan R.S. Arch

      Affiliations

    • Clore Laboratory for Life Sciences, University of Buckingham, MK18 1EG Buckingham, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 1280 820306; fax: +44 1280 820135.

Received 28 May 2008; received in revised form 24 July 2008; accepted 29 July 2008. published online 17 October 2008.

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☆ Funding: Claire Cornick was supported by the UK Biotechnology and Biological Sciences Research Council and Unilever Research.

☆☆ Unilever has applied for patents on commipheric acid but does not market commipheric acid or guggulipid.

PII: S0955-2863(08)00172-1

doi:10.1016/j.jnutbio.2008.07.010

The Journal of Nutritional Biochemistry
Volume 20, Issue 10 , Pages 806-815, October 2009

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