The Journal of Nutritional Biochemistry
Volume 18, Issue 10 , Pages 685-692 , October 2007

Extra virgin olive oil increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats

  • Yuriko Oi-Kano

      Affiliations

    • Laboratory of Nutrition Chemistry, Faculty of Home Economics, Kobe Women's University, Suma-ku, Kobe 654-8585, Japan
    • Corresponding Author InformationCorresponding author. Laboratory of Nutrition Chemistry, Faculty of Home Economics, Kobe Women's University, 2-1 Aoyama, Higashisuma, Suma-ku, Kobe 654-8585, Japan. Tel.: +81 78 737 2438; fax: +81 78 732 5161.
    • ,
  • Teruo Kawada

      Affiliations

    • Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture (Uji Campus), Kyoto University, Uji, Kyoto 611-0011, Japan
    • ,
  • Tatsuo Watanabe

      Affiliations

    • School of Food and Nutritional Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, 422-8526, Japan
    • ,
  • Fumihiro Koyama

      Affiliations

    • J-Oil Mills, Inc. Tsurumi-ku, Yokohama 230-0053, Japan
    • ,
  • Kenichi Watanabe

      Affiliations

    • J-Oil Mills, Inc. Tsurumi-ku, Yokohama 230-0053, Japan
    • ,
  • Reijirou Senbongi

      Affiliations

    • Sugiyama Chemical and Industrial Laboratory, Totsuka-ku, Yokohama 245-0064, Japan
    • ,
  • Kazuo Iwai

      Affiliations

    • Laboratory of Nutrition Chemistry, Faculty of Home Economics, Kobe Women's University, Suma-ku, Kobe 654-8585, Japan

Received 29 June 2006 ,Revised 5 November 2006 ,Accepted 10 November 2006.

References 

  1. Visioli F, Galli C. Biological properties of olive oil phytochemicals. Crit Rev Food Sci Nutr. 2002;42:209–221
  2. Keys A. Mediterranean diet and public health: personal reflections. Am J Clin Nutr. 1995;61(Suppl):1321S–1323S
  3. Stark AH, Mader Z. Olive oil as a functional food: epidemiology and nutritional approaches. Nutr Rev. 2002;60:170–176
  4. Lastra CA, Barranco MD, Herrerias JM. Mediterranean diet and health: biological importance of olive oil. Curr Pharm Des. 2001;7:933–950
  5. Sanders TAB. Olive oil and the Mediterranean diet. Int J Vitam Nutr Res. 2001;71:179–184
  6. Lavelli V. Comparison of the antioxidant activities of extra virgin olive oils. J Agric Food Chem. 2002;50:7704–7708
  7. Visioli F, Galli C. The effect of minor constituents of olive oil on cardiovascular disease: new findings. Nutr Rev. 1998;55:142–147
  8. Tuck KL, Hayball PJ. Major phenolic compounds in olive oil: metabolism and health. J Nutr Biochem. 2002;13:636–644
  9. Visioli F, Galli C. Oleuropein protects low density lipoprotein from oxidation. Life Sci. 1994;55:1965–1971
  10. Vissers MN, Zock PL, Katan MB. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr. 2004;58:955–965
  11. Visioli F, Galli C. Olive oil phenols and their potential effects on human health. J Agric Food Chem. 1998;46:4292–4296
  12. Visioli F, Poli A, Galli C. Antioxidant and other biological activities of phenols from olive and olive oil. Med Res Rev. 2002;22:65–75
  13. Himms Hagen J. Brown adipose tissue metabolism. In:  Bjorntorp P,  Brodoff BN editor. Obesity. Philadelphia: Lippincott; 1992;p. 15–34
  14. Landsberg L, Young JB. Diet-induced changes in sympathoadrenal activity: implications for thermogenesis. Life Sci. 1981;28:1801–1819
  15. Levin BE, Triscari J, Sullivan C. Altered sympathetic activity during development of diet-induced obesity in rat. Am J Physiol. 1983;244:R347–R355
  16. Deseautels M, Himms-Hagen J. Roles of noradrenaline and protein synthesis in the cold-induced increase in purine nucleotide binding by rat brown adipose tissue mitochondria. Can J Biochem. 1979;57:968–976
  17. Mory G, Bouillaud F, Combes-George M, Riquire D. Noradrenaline controls the concentration of the uncoupling protein in brown adipose tissue. FEBS Lett. 1984;166:393–397
  18. Rothwell NJ, Stock MJ. A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979;281:31–35
  19. Boss O, Samec S, Dulloo A, Seydoux J, Muzzin P, Giacobino J-P. Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett. 1997;412:111–114
  20. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997;15:269–272
  21. Klingenberg M. Mechanism and evolution of the uncoupling protein of brown adipose tissue. Trends Biochem Sci. 1990;15:108–112
  22. Rodriguez VM, Portillo MP, Pico C, Macarulla MT, Palou A. Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle. Am J Clin Nutr. 2001;75:213–220
  23. Grignaffini P, Roma P, Galli C, Catapano AL. Protection of low-density lipoprotein from oxidation by 3,4-dihydroxyphenylethanol. Lancet. 1994;343:1296–1297
  24. Papadopoulos G, Boskou D. Antioxidant effect of natural phenols on olive oil. J Am Oil Chem Soc. 1991;68:669–671
  25. Favati F, Caporale E, Bertuccioli M. Rapid extraction and determination of phenols in extra virgin olive oil. In:  Charalambous G editors. Food flavors: generation, analysis and process influence. The Netherlands: Elsevier Science; 1995;p. 429–452
  26. Maggi CA, Meli A. Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1: general considerations. Experientia. 1986;42:109–210
  27. Bai C, Yan X, Takenaka M, Sekiya K, Nagata T. Determination of synthetic hydroxytyrosol in rat plasma by GC-MS. J Agric Food Chem. 1998;46:3998–4001
  28. Davidson DF, Fitzpatrick J. A simple, optimised and rapid assay for urinary free catecholamines by HPLC with electrochemical detection. Ann Clin Biochem. 1985;22:297–303
  29. Clark LC, Thompson IL. Determination of creatine and creatinine in urine. Anal Chem. 1949;21:1218–1221
  30. Pearson S, Stern S, McGavack TH. A rapid, accurate method for the determination of total cholesterol in serum. Anal Chem. 1953;25:813–814
  31. Kawada T, Sakabe S, Aoki N, Watanabe T, Higeta K, Iwai K, et al. Intake of sweeteners and pungent ingredients increase the thermogenin content in brown adipose tissue of rat. J Agric Food Chem. 1991;39:651–654
  32. Cannon B, Lindberg O. Mitochondria from brown adipose tissue: isolation and properties. Methods Enzymol. 1979;55:65–78
  33. Hikichi Y, Sugihara H. Differentiation of brown adipose cells in three-dimensional collagen gel culture. Pathol Res Pract. 1993;189:73–82
  34. Tsukazaki K, Nikami H, Shimizu Y, Kawada T, Yoshida T, Saito M. Chronic administration of β-adrenergic agonists can mimic the stimulative effect of cold exposure on protein synthesis in rat brown adipose tissue. J Biochem. 1995;117:96–100
  35. Watanabe T, Kawada T, Kurosawa M, Sato A, Iwai K. Adrenal sympathetic efferent nerve and catecholamine secretion excitation caused by capsaicin in rats. Am J Physiol. 1988;255:E23–E27
  36. Awad AB. Effect of dietary lipids on composition and glucose utilization by rat adipose tissue. J Nutr. 1981;111:34–39
  37. Mercer SW, Trayhurn P. Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice. J Nutr. 1987;117:2147–2153
  38. Paik HS, Yearlick ES. The influence of dietary fat and meal frequency on lipoprotein lipase and hormone-sensitive lipase in rat adipose tissue. J Nutr. 1978;108:1798–1805
  39. Shimomura Y, Tamura T, Suzuki M. Less body fat accumulation in rats fed safflower oil diet than in rats fed a beef tallow diet. J Nutr. 1990;120:1291–1296
  40. Visioli F, Galli C, Bornet F, Mattei A, Patelli R, Galli G, et al. Olive oil phenolics are dose-dependently absorbed in humans. FEBS lett. 2000;468:159–160
  41. Vissers MN, Zock PL, Roodenburg AJC, Leenen R, Katan MB. Olive oil phenols are absorbed in humans. J Nutr. 2002;132:409–417
  42. Oi Y, Kawada T, Shishido C, Wada K, Kominato Y, Nishimura S, et al. Allyl-containing sulfides in garlic increase uncoupling protein content in brown adipose tissue, and noradrenaline and adrenaline secretion in rats. J Nutr. 1999;129:336–342

☆ This study was supported by the Japan Society for the promotion of Science [Grants-in-Aid for Scientific Research (C) 18500633, 2006].

PII: S0955-2863(07)00013-7

doi: 10.1016/j.jnutbio.2006.11.009

The Journal of Nutritional Biochemistry
Volume 18, Issue 10 , Pages 685-692 , October 2007

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