The Journal of Nutritional Biochemistry
Volume 18, Issue 10 , Pages 667-675 , October 2007

Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models

  • Hsin-Chung Cheng

      Affiliations

    • Orthodontic Department, Taipei Medical University Hospital, Taipei Medical University, Taipei 110, Taiwan
    • ,
  • Hsin Chien

      Affiliations

    • School of Pharmaceutical Science, Taipei Medical University, Taipei 110, Taiwan
    • ,
  • Chia-Hui Liao

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
    • ,
  • Yi-Yuan Yang

      Affiliations

    • School of Medical Technology and Biotechnology, Taipei Medical University, Taipei 110, Taiwan
    • ,
  • Shih-Yi Huang

      Affiliations

    • School of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
    • Corresponding Author InformationCorresponding author. Tel.: +886 2 27361661x6551 to 120; fax: +886 2 27373112.

Received 7 August 2006 ,Revised 12 October 2006 ,Accepted 27 October 2006.

References 

  1. Stich HF, Mathew B, Sankaranarayanan R, Nair MK. Remission of precancerous lesions in the oral cavity of tobacco chewers and maintenance of the protective effect of beta-carotene or vitamin A. Am J Clin Nutr. 1991;53:298S–304S
  2. Suri K, Goldman HM, Wells H. Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch. Nature. 1971;230:383–384
  3. Odukoya O, Shklar G. Two-phase carcinogenesis in hamster buccal pouch. Oral Surg Oral Med Oral Pathol. 1982;54:547–552
  4. Betel-quid and Areca-nut chewing . IARC. Monogr Eval Carcinog Risk Chem Hum. 1985;37:137–202
  5. McCormick D, Hall PA. The complexities of proliferating cell nuclear antigen. Histopathology. 1992;21:591–594
  6. Hall PA, Coates PJ, Goodlad RA, Hart IR, Lane DP. Proliferating cell nuclear antigen expression in non-cycling cells may be induced by growth factors in vivo. Br J Cancer. 1994;70:244–247
  7. Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature. 1987;326:515–517
  8. Jaskulski D, deRiel JK, Mercer WE, Calabretta B, Baserga R. Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science. 1988;240:1544–1546
  9. Shin DM, Voravud N, Ro JY, Lee JS, Hong WK, Hittelman WN. Sequential increases in proliferating cell nuclear antigen expression in head and neck tumorigenesis: a potential biomarker. J Natl Cancer Inst. 1993;85:971–978
  10. Krecicki T, Jelen M, Zalesska-Krecicka M, Rak J, Szkudlarek T, Jelen-Krzeszewska J. Epidermal growth factor receptor (EGFR), proliferating cell nuclear antigen (PCNA) and Ki-67 antigen in laryngeal epithelial lesions. Oral Oncol. 1999;35:180–186
  11. Bova RJ, Quinn DI, Nankervis JS, Cole IE, Sheridan RL, Jensen MJ, et al. Cyclin D1 and p16INK4a expression predict reduced survival in carcinoma of the anterior tongue. Clin Cancer Res. 1999;5:2810–2989
  12. Chien H, Huang SY, Lin YH, Hsieh YS, Hsieh MJ, Shieh MJ. The preventive effect of carotenoids on DMBA induced oral carcinoma in male hamsters. J Nutr Sci. 2000;25:199–206[in Chinese]
  13. Bhuvaneswari V, Velmurugan B, Balasenthil S, Ramachandran CR, Nagini S. Chemopreventive efficacy of lycopene on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Fitoterapia. 2001;72:865–874
  14. Lin LM, Chen YK, Lai DR, Huang YL, Chen HR. Cancer-promoting effect of Taiwan betel quid in hamster buccal pouch carcinogenesis. Oral Dis. 1997;3:232–235
  15. Twentyman PR, Fox NE, Rees JK. Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay. Br J Haematol. 1989;71:19–24
  16. Hotz MA, Gong J, Traganos F, Darzynkiewicz Z. Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry. 1994;15:237–244
  17. Volk T, Geiger B, Raz A. Motility and adhesive properties of high- and low-metastatic murine neoplastic cells. Cancer Res. 1984;44:811–824
  18. Sundqvist K, Liu Y, Nair J, Bartsch H, Arvidson K, Grafstrom RC. Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res. 1989;49:5294–5298
  19. Dave BJ, Trivedi AH, Adhvaryu SG. Role of areca nut consumption in the cause of oral cancers. A cytogenetic assessment. Cancer. 1992;70:1017–1023
  20. Chiang CP, Lang MJ, Liu BY, Wang JT, Leu JS, Hahn LJ, et al. Expression of proliferating cell nuclear antigen (PCNA) in oral submucous fibrosis, oral epithelial hyperkeratosis and oral epithelial dysplasia in Taiwan. Oral Oncol. 2000;36:353–359
  21. Kozuki Y, Miura Y, Yagasaki K. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett. 2000;151:111–115
  22. Toma S, Albanese E, Palumbo R, Nicolo G, Morerio C, Magiante PE, et al. In vitro effects of beta-carotene on human oral keratinocytes from precancerous lesions and squamous carcinoma. Anticancer Drugs. 1991;2:581–589
  23. Livny O, Kaplan I, Reifen R, Polak-Charcon S, Madar Z, Schwartz B. Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells. J Nutr. 2002;132:3754–3759
  24. Hieber AD, King TJ, Morioka S, Fukushima LH, Franke AA, Bertram JS. Comparative effects of all-trans beta-carotene vs. 9-cis beta-carotene on carcinogen-induced neoplastic transformation and connexin 43 expression in murine 10T1/2 cells and on the differentiation of human keratinocytes. Nutr Cancer. 2000;37:234–244
  25. Stivala LA, Savio M, Cazzalini O, Pizzala R, Rehak L, Bianchi L, et al. Effect of beta-carotene on cell cycle progression of human fibroblasts. Carcinogenesis. 1996;17:2395–2401
  26. Nahum A, Hirsch K, Danilenko M, Watts CK, Prall OW. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes. Oncogene. 2001;20:3428–3436
  27. Zhang LX, Cooney RV, Bertram JS. Carotenoids up-regulate connexin43 gene expression independent of their provitamin A or antioxidant properties. Cancer Res. 1992;52:5707–5712
  28. Bohm F, Tinkler JH, Truscott TG. Carotenoids protect against cell membrane damage by the nitrogen dioxide radical. Nat Med. 1995;1:98–99

☆ This work was partially supported by grants from the National Science Council (NSC92-2321-B-038-006 and NSC93-2321-B-038-010) and Taipei Medical University Hospital (94TMU-TMUH-06) of Taiwan.

PII: S0955-2863(07)00009-5

doi: 10.1016/j.jnutbio.2006.10.010

The Journal of Nutritional Biochemistry
Volume 18, Issue 10 , Pages 667-675 , October 2007

Article Tools

* Image Usage & Resolution