The Journal of Nutritional Biochemistry
Volume 18, Issue 8 , Pages 519-524 , August 2007

Meal cysteine improves postprandial glucose control in rats fed a high-sucrose meal

  • Clemence Blouet

      Affiliations

    • UMR 914 INRA, INAPG, Nutrition Physiology and ingestive behavior, Institut National Agronomique, Paris 75005, France
    • Supported by an MRT grant from the French ministry for research.
  • ,
  • François Mariotti

      Affiliations

    • UMR 914 INRA, INAPG, Nutrition Physiology and ingestive behavior, Institut National Agronomique, Paris 75005, France
  • ,
  • Takashi Mikogami

      Affiliations

    • Armor Protéines SAS, 35460 Saint-Brice-en-Coglès, France
  • ,
  • Daniel Tome

      Affiliations

    • UMR 914 INRA, INAPG, Nutrition Physiology and ingestive behavior, Institut National Agronomique, Paris 75005, France
  • ,
  • Jean-François Huneau

      Affiliations

    • UMR 914 INRA, INAPG, Nutrition Physiology and ingestive behavior, Institut National Agronomique, Paris 75005, France
    • Corresponding Author InformationCorresponding author.

Received 6 June 2006 ,Revised 19 July 2006 ,Accepted 3 October 2006.

References 

  1. Hall WL, Millward DJ, Long SJ, Morgan LM. Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite. Br J Nutr. 2003;89:239–248
  2. Ha E, Zemel MB. Functional properties of whey, whey components, and essential amino acids: mechanisms underlying health benefits for active people (review). J Nutr Biochem. 2003;14:251–258
  3. Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med. 2001;30:1191–1212
  4. Bounous G, Gervais F, Amer V, Batist G, Gold P. The influence of dietary whey protein on tissue glutathione and the diseases of aging. Clin Invest Med. 1989;12:343–349
  5. Mariotti F, Simbelie KL, Makarios-Lahham L, Huneau JF, Laplaize B, Tome D, et al. Acute ingestion of dietary proteins improves post-exercise liver glutathione in rats in a dose-dependent relationship with their cysteine content. J Nutr. 2004;134:128–131
  6. Khamaisi M, Kavel O, Rosenstock M, Porat M, Yuli M, Kaiser N, et al. Effect of inhibition of glutathione synthesis on insulin action: in vivo and in vitro studies using buthionine sulfoximine. Biochem J. 2000;349:579–586
  7. Paolisso G, Di Maro G, Pizza G, D'Amore A, Sgambato S, Tesauro P, et al. Plasma GSH/GSSG affects glucose homeostasis in healthy subjects and non-insulin-dependent diabetics. Am J Physiol. 1992;263:E435–E440
  8. Ammon HP, Klumpp S, Fuss A, Verspohl EJ, Jaeschke H, Wendel A, et al. A possible role of plasma glutathione in glucose-mediated insulin secretion: in vitro and in vivo studies in rats. Diabetologia. 1989;32:797–800
  9. Sies H, Stahl W, Sevanian A. Nutritional, dietary and postprandial oxidative stress. J Nutr. 2005;135:969–972
  10. Meister A. New aspects of glutathione biochemistry and transport-selective alteration of glutathione metabolism. Nutr Rev. 1984;42:397–410
  11. Burvin R, Zloczower M, Karnieli E. Double-vein jugular/inferior vena cava clamp technique for long-term in vivo studies in rats. Physiol Behav. 1998;63:511–515
  12. Ganafa AA, Socci RR, Eatman D, Silvestrova N, Abukhalaf IK, Bayorh MA. Acute inhibition of glutathione biosynthesis alters endothelial function and blood pressure in rats. Eur J Pharmacol. 2002;454:217–223
  13. Belfiore F, Iannello S. Insulin resistance in obesity: metabolic mechanisms and measurement methods. Mol Genet Metab. 1998;65:121–128
  14. Anderson ME. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 1985;113:548–555
  15. White CC, Viernes H, Krejsa CM, Botta D, Kavanagh TJ. Fluorescence-based microtiter plate assay for glutamate-cysteine ligase activity. Anal Biochem. 2003;318:175–180
  16. Stipanuk MH. Role of the liver in regulation of body cysteine and taurine levels: a brief review. Neurochem Res. 2004;29:105–110
  17. Richie JP, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, et al. Tissue glutathione and cysteine levels in methionine-restricted rats. Nutrition. 2004;20:800–805
  18. Ammon HP, Muller PH, Eggstein M, Wintermantel C, Aigner B, Safayhi H, et al. Increase in glucose consumption by acetylcysteine during hyperglycemic clamp. A study with healthy volunteers. Arzneimittelforschung. 1992;42:642–645
  19. Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, et al. N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress. Am J Physiol Endocrinol Metab. 2003;285:E744–E753
  20. Guarino MP, Afonso RA, Raimundo N, Raposo JF, Macedo MP. Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action. Am J Physiol Gastrointest Liver Physiol. 2003;284:G588–G594
  21. Lautt WW. A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis. J Pharmacol Sci. 2004;95:9–17
  22. Calbet JA, MacLean DA. Plasma glucagon and insulin responses depend on the rate of appearance of amino acids after ingestion of different protein solutions in humans. J Nutr. 2002;132:2174–2182
  23. Frid AH, Nilsson M, Holst JJ, Bjorck IM. Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects. Am J Clin Nutr. 2005;82:69–75
  24. Doi M, Yamaoka I, Fukunaga T, Nakayama M. Isoleucine, a potent plasma glucose-lowering amino acid, stimulates glucose uptake in C2C12 myotubes. Biochem Biophys Res Commun. 2003;312:1111–1117
  25. Nishitani S, Matsumura T, Fujitani S, Sonaka I, Miura Y, Yagasaki K. Leucine promotes glucose uptake in skeletal muscles of rats. Biochem Biophys Res Commun. 2002;299:693–696

PII: S0955-2863(06)00230-0

doi: 10.1016/j.jnutbio.2006.10.002

The Journal of Nutritional Biochemistry
Volume 18, Issue 8 , Pages 519-524 , August 2007