The Journal of Nutritional Biochemistry
Volume 18, Issue 5 , Pages 322-331 , May 2007

Regulation of adipocyte differentiation by PEGylated all-trans retinoic acid: reduced cytotoxicity and attenuated lipid accumulation

  • H.S. Moon

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • D.D. Guo

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • H.H. Song

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • I.Y. Kim

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • H.L. Jin

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • Y.K. Kim

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • C.S. Chung

      Affiliations

    • College of Agriculture, Life and Environment Sciences, Chungbuk National University, Cheongju 361-763, South Korea
    • ,
  • Y.J. Choi

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • H.K. Lee

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • ,
  • C.S. Cho

      Affiliations

    • School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, South Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 880 4636; fax: +82 2 875 2494.

Received 24 March 2006 ,Revised 19 June 2006 ,Accepted 27 June 2006.

References 

  1. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrel MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab. 2001;280:E827–E847
  2. Tang QQ, Jiang MS, Lane MD. Possible role of SpI as repressor of the C/EBPα gene in the adipocyte differentiation program. Mol Cell Biol. 1999;19:4855–4865
  3. Alessi MC, Lijnen HR, Bastelica D, Irene JV. Adipose tissue and atherothrombosis. Pathophysiol Haemost Thromb. 2004;33:290–297
  4. Kelly DE, Goodpaster BH. Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance. Diabetes Care. 2001;24:933–941
  5. Lewis GF, Carpentier A, Adeli K, Giacca A. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev. 2002;23:201–209
  6. Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. 2001;50:S118–S121
  7. Cho KJ, Moon HE, Moini H, Packer L, Yoon DY, Chung AS. α-Lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways. J Biol Chem. 2003;278:34823–34833
  8. Suryawan A, Hu CY. Effect of retinoic acid on differentiation of cultured pig preadipocytes. J Anim Sci. 1997;75:112–127
  9. Choi YD, Kim SY, Kim SH, Lee KS, Kim CH, Byun YR. Long-term delivery of all-trans-retinoic acid using biodegradable PLLA/PEG–PLLA blended microspheres. Int J Pharm. 2001;215:67–81
  10. Toma S, Isnardi L, Raffo P, Dastoli G, De Francisci E, Riccardt L, et al. Effects of all-trans-retinoic acid and 13-cis-retinoic acid on breast-cancer cell lines: growth inhibition and apoptosis induction. Int J Cancer. 1997;70:619–627
  11. Kalmekerian GP, Jasti RK, Celano P, Nelkin BD, Maarby M. All-trans-retinoic acid alters myc gene expression and inhibits in vitro progression in small-cell lung cancer. Cell Growth Differ. 1994;5:55–60
  12. Giannini F, Maestro R, Vukosa T, Ijevic TV, Pomponi F, Boiocchi M. All-trans, 13-cis and 9-cis retinoic acids induce a fully reversible growth inhibition in HNSCC cell lines: implications for in vivo retinoic acid use. Int J Cancer. 1997;70:194–200
  13. Ohyama M, Matsuda K, Torii S, Matsui T, Yano H, Kawada T, et al. The interaction between vitamin A and thiazolidinedione on bovine adipocyte differentiation in primary culture. J Anim Sci. 1998;76:61–65
  14. Gazit D, Ebner R, Kahn AJ, Derynck R. Modulation of expression and cell surface binding of members of the transforming growth factor beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells. Mol Endocrinol. 1993;7:189–198
  15. Leboy PS, Beresford JN, Devlin C, Owen ME. Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures. J Cell Physiol. 1991;146:370–378
  16. Sklan D. Vitamin A in human nutrition. Prog Food Nutr Sci. 1987;1:39–55
  17. Snodgrass SR. Vitamin neurotoxicity. Mol Neurobiol. 1992;1:41–73
  18. Frankel SR, Eardley A, Lauwers G, Weiss M, Warrell RP. The “retinoic acid syndrome” in acute promyelocytic leukemia. Ann Intern Med. 1992;117:292–296
  19. Chawla A, Lazar M. Peroxisome proliferators and retinoid signaling pathways coregulate preadipocyte phenotype and survival. Proc Natl Acad Sci U S A. 1994;91:1786
  20. Delgado C, Francis GE, Fisher D. The uses and properties of PEG-linked proteins. Crit Rev Ther Drug Carrier Syst. 1992;9:249–304
  21. Allen TM. Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trends Pharmacol Sci. 1994;15:215–220
  22. Greenwald RB, Choe YH, Mcguire J, Conover CD. Effective drug delivery by PEGylated drug conjugates. Adv Drug Deliv Rev. 2003;55:217–250
  23. Tobio M, Sanchez A, Vila A, Soriano I, Evora C, Vila-Jato JL, et al. The role of PEG on the stability in digestive fluids and in vivo fate of PEG–PLA nanoparticles following oral administration. Colloids Surf B. 2000;18:315–323
  24. Fleming AB, Haverstick K, Saltzman WM. In vitro cytotoxicity and in vivo distribution after direct delivery of PEG–camptothecin conjugated to the rat brain. Bioconjug Chem. 2004;15:1364–1375
  25. Scott MD, Chen AM. Au-dela du GR: traitement par PEG des cellules sanguines et autres tissue (Beyond the red cell: pegylation of other blood cells and tissues), Transfus Clin Biol. 2004;11:40–46
  26. Wise LS, Green H. Participation of one isozyme of cytosolic glycerophosphate in adipose conversion of 3T3 cells. J Biol Chem. 1979;254:273–275
  27. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem. 1976;72:248–254
  28. Suryawan A, Hu CY. Effect of serum on differentiation of porcine adipose stromal–vascular cells in primary culture. Comp Biochem Physiol. 1993;105A:485–492
  29. Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 2005;19:311–330
  30. Kim K, Luu YK, Chang C, Fang D, Hsiao BS, Chu B, et al. Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide–co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release. 2004;98:47–56
  31. Harris JM. Poly(ethylene glycol) chemistry: biotechnical and biomedical applications. New York: Plenum; 1992;
  32. Harp JB. New insights into inhibitors of adipogenesis. Curr Opin Lipidol. 2004;15:303–307
  33. Brisaert M, Gabriels M, Plaizier-Vercammen J. Investigation of the chemical stability of an erythromycin–tretionin lotion by the use of an optimization system. Int J Pharm. 2000;197:153–160
  34. Claudia FP. Safety assessment on poly(ethylene glycols) (PEGs) and their derivatives as used in cosmetic products. Toxicology. 2005;214:1–38
  35. Mu L, Feng SS. PLGA/TPGS nanoparticles for controlled release of paclitaxel; effects of the emulsifier and drug loading ratio. Pharm Res. 2003;20:1864–1872
  36. Cao Z, Umek RM, Mcknight SL. Regulated expression of three C/EBP isomers during adipose conversion of 3T3-L1 cells. Genes Dev. 1991;5:1538–1552
  37. Shao D, Lazar MA. Peroxisome proliferators activated receptor γ, CCAAT/enhancer binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. J Biol Chem. 1997;272:21473–21478
  38. Kichler A. Gene transfer with modified polyethylenimines. J Gene Med. 2004;6:S3–S10
  39. Kwon GS, Kataoka K. Block copolymer micelles as long circulating drug vehicles. Adv Drug Deliv Rev. 1995;16:295–309
  40. Burris TP, Pelton PD, Zhou L, Osborne MC, Cryan E, Demarest KT. A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferators-activated receptor gamma agonist actions aP2 gene expression detected using branched DNA messenger RNA quantitation. Mol Endocrinol. 1999;13:410–417
  41. Scavo LM, Karas M, Murray M, Leroith D. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cell into adipocytes. J Clin Endocrinol. 2004;89:3543–3553
  42. Kawada T, Kamei Y, Fujita A, Hida Y, Takahashi N, Sugimoto E, et al. Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. Biofactors. 2000;13:103–109
  43. Tontonoz P, Hu E, Spiegelman BM. Regulation of adipocyte gene expression and differentiation by peroxisome proliferators-activated receptor gamma. Curr Opin Genet Dev. 1995;5:571–576
  44. Gearing KL, Gottlicher M, Widmark E, Banner CD, Tollet P, Stromstedt M, et al. Fatty acid activation of the peroxisome proliferators activated receptor, a member of the nuclear receptor gene superfamily. J Nutr. 1994;124:1284–1288
  45. Dalei S, Lazar MA. Peroxisome proliferators activated receptor γ, CCAAT/enhancer-binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation. 1997;272:21473–8.
  46. Torii S, Matsumoto K, Maysui T, Yano H. Effect of vitamin A, C and D on glycerol-3-phosphate dehydrogenase activity of sheep preadipocytes in primary culture. Anim Sci Technol. 1995;66:1039–1042
  47. Schwarz EJ, Reginato MJ, Shao D, Krakow SL, Lazar MA. Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription. Mol Cell Biol. 1997;17:1552–1561
  48. Brebourg TD, Hu CY. Regulation of differentiating pig preadipocytes by retinoic acid. J Anim Sci. 2005;83:98–107
  49. Shirui M, Xintao S, Florian U, Mittmar W, Xiulan X, et al. Synthesis, characterization and cytotoxicity of poly(ethylene glycol)–graft–trimethyl chitosan block copolymer. Biomaterials. 2005;26:6343–6356
  50. Li C, Yu D, Inoue T, Yang DJ, Milas L, Hunter NR, et al. Synthesis and evaluation of water-soluble polyethylene glycol–paclitaxel conjugate as a paclitaxel prodrug. Anticancer Drugs. 1996;7:642–648

PII: S0955-2863(06)00161-6

doi: 10.1016/j.jnutbio.2006.06.004

The Journal of Nutritional Biochemistry
Volume 18, Issue 5 , Pages 322-331 , May 2007

Article Tools

* Image Usage & Resolution