The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 435-437 , July 2005

Marginal biotin deficiency is teratogenic in mice and perhaps humans: a review of biotin deficiency during human pregnancy and effects of biotin deficiency on gene expression and enzyme activities in mouse dam and fetus

Received 30 March 2005 ,Revised 30 March 2005 ,Accepted 30 March 2005.

References 

  1. Mock NI, Malik MI, Stumbo PJ, Bishop WP, Mock DM. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased status in experimental biotin deficiency. Am J Clin Nutr. 1997;65:951–958
  2. Mock DM, Henrich CL, Carnell N, Mock NI. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am J Clin Nutr. 2002;76:1061–1068
  3. Mock DM, Stadler DD. Conflicting indicators of biotin status from a cross-sectional study of normal pregnancy. J Am Coll Nutr. 1997;16:252–257
  4. Mock DM, Stadler DD, Stratton SL, Mock NI. Biotin status assessed longitudinally in pregnant women. J Nutr. 1997;127:710–716
  5. Wang K-S, Mock NI, Mock DM. Biotin biotransformation to bisnorbiotin is accelerated by several peroxisome proliferators and steroid hormones in rats. J Nutr. 1997;127:2212–2216
  6. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr. 2002;75:295–299
  7. Mock DM, Mock NI, Stewart CW, LaBorde JB, Hansen DK. Marginal biotin deficiency is teratogenic in ICR mice. J Nutr. 2003;133:2519–2525
  8. Sealey W, Stratton S, Mock D, Hansen D. M maternal biotin deficiency in CD-1 mice reduces fetal mass of biotin-dependent carboxylases. J Nutr. 2005;[in press]
  9. Zempleni J, Mock DM. Marginal biotin deficiency is teratogenic. Proc Soc Exp Biol Med. 2000;223:14–21

☆ Presented at the “Biotin Symposium, NAFTA Satellite Meeting to the XXV National Congress of Biochemistry” held December 3–4, 2004, in Ixtapa, Zihuatanejo, Mexico. This meeting was sponsored by Sociedad Mexicana de Bioquimica A.C. and Programa de Doctorado en Ciencias Biomédicas, Universidad Nacinal Autónoma de México.

PII: S0955-2863(05)00095-1

doi: 10.1016/j.jnutbio.2005.03.022

The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 435-437 , July 2005

Article Tools