The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 432-434 , July 2005

Biotin-dependent regulation of gene expression in human cells

Received 30 March 2005 ,Revised 30 March 2005 ,Accepted 30 March 2005.

References 

  1. Wolf B. Disorders of biotin metabolism. In:  Scriver C,  William S,  Valle D editor. The metabolic and molecular bases of inherited disease. McGraw-Hill Professional; 2001;p. 3935–3962
  2. Pacheco-Alvarez D, Solorzano-Vargas RS, Del Rio AL. Biotin in metabolism and its relationship to human disease. Arch Med Res. 2002;33(5):439–447
  3. Stanley JS, et al. Biotin uptake into human peripheral blood mononuclear cells increases early in the cell cycle, increasing carboxylase activities. J Nutr. 2002;132(7):1854–1859
  4. Baur B, Suormala T, Baumgartner ER. Biocytin and biotin uptake into NB2a neuroblastoma and C6 astrocytoma cells. Brain Res. 2002;925(2):111–121
  5. León-Del-Río A, et al. Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli. Proc Natl Acad Sci U S A. 1995;92(10):4626–4630
  6. Solórzano-Vargas S, Pacheco-Alvarez D, León Del Río A. Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells. Proc Natl Acad Sci. 2002;99(8):5325–5330
  7. Stockert RJ, Ren Q. Cytoplasmic protein mRNA interaction mediates cGMP-modulated translational control of the asialoglycoprotein receptor. J Biol Chem. 1997;272(14):9161–9165
  8. Stockert RJ. Regulation of the human asialoglycoprotein receptor by cAMP. J Biol Chem. 1993;268(26):19540–19544
  9. Rodriguez-Melendez R, et al. Biotin regulates the genetic expression of holocarboxylase synthetase and mitochondrial carboxylases in rats. J Nutr. 2001;131(7):1909–1913
  10. Pacheco-Alvarez D, et al. Paradoxical regulation of biotin utilization in brain and liver and implications for inherited multiple carboxylase deficiency. J Biol Chem. 2004;279(50):52312–52318
  11. Stockert RJ. The asialoglycoprotein receptor: relationships between structure, function, and expression. Physiol Rev. 1995;75(3):591–609
  12. De La Vega LA, Stockert RJ. Regulation of the insulin and asialoglycoprotein receptors via cGMP-dependent protein kinase. Am J Physiol Cell Physiol. 2000;279(6):C2037–C2042
  13. Rodriguez-Melendez R, Perez-Andrade ME, Diaz A, Deolarte A, Camacho-Arroyo I, Ciceron I. Differential effects of biotin deficiency and replenishment on rat liver pyruvate and propionyl-CoA carboxylases and on their mRNAs. Mol Genet Metab. 1999;66(1):16–23
  14. Ugarte M, et al. Overview of mutations in the PCCA and PCCB genes causing propionic acidemia. Hum Mutat. 1999;14(4):275–282
  15. Chiang GS, Mistry SP. Activities of pyruvate carboxylase and propionyl CoA carboxylase in rat tissues during biotin deficiency and restoration of the activities after biotin administration. Proc Soc Exp Biol Med. 1974;146(1):21–24
  16. Pacheco-Alvarez D, Solórzano-Vargas RS, González-Noriega A, Michalak C, Zempleni J, León-Del-Río A. Biotin availability regulates expression of the sodium-dependent multivitamin transporter and the rate of biotin uptake in HepG2 cells. Molec Genet Metab (in press).

 This work was presented at the “International Symposium Vitamins as Regulators of Gene Expression: Biotin as a Model” held December 3–4, 2004 in Ixtapa Zihuatanejo, Mexico. The meeting was sponsored by Sociedad Mexicana de Bioquímica, Laboratorios Roche-Syntex México and Programa de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México.

PII: S0955-2863(05)00094-X

doi: 10.1016/j.jnutbio.2005.03.021

The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 432-434 , July 2005