The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 424-427 , July 2005

Pharmacological effects of biotin

This paper was presented at the international symposium “Vitamins as Regulators of Genetic Expression: Biotin as a Model” NAFTA Satellite Meeting to the XXV National Congress of Biochemistry” held on December 3–4, 2004, in Ixtapa, Zihuatanejo, Mexico. This meeting was sponsored by Sociedad Mexicana de Bioquimica A.C.; Programa de Doctorado en Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico; Laboratorios Roche–Syntex, Mexico; and Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico.

Received 30 March 2005 ,Revised 30 March 2005 ,Accepted 30 March 2005.

References 

  1. Carlberg C. Lipid soluble vitamins in gene regulation. Biofactors. 1999;10:91–97
  2. Balmer JE, Blomhoff R. Gene expression regulation by retinoic acid. J Lipid Res. 2002;43:1773–1808
  3. Chistakos S, Dhawan P, Liu Y, Peng X, Porta A. New insights into the mechanism of vitamin D action. J Cell Biochem. 2003;88:695–705
  4. Combs GF. Biotin. In: The vitamins. Fundamental aspects in nutrition and health. 2nd ed.. San Diego: Academic Press Inc.; 1994;p. 329–345
  5. Hinds TS, West WL, Knight EM. Carotenoids and retinoids: a review of research, clinical, and public health applications. J Clin Pharmacol. 1997;37:551–558
  6. Wu-Wong JR, Tian J, Goltzman D. Vitamin D analogs as therapeutic agents: a clinical study update. Curr Opin Investig Drugs. 2004;5:320–326
  7. Brandsch R. Regulation of gene expression by cofactors derived from B vitamins. J Nutr Sci Vitaminol. 1994;40:371–399
  8. Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J. 1994;8:343–349
  9. Rodriguez-Melendez R, Zempleni J. Regulation of gene expression by biotin. J Nutr Biochem. 2003;14:680–690
  10. Dakshinamurti K, Chauhan J. Biotin-binding proteins. In:  Dakshinamurti K editors. Vitamin receptors: vitamins as ligands in cell communication. vol. 1:Cambridge: University Press; 1994;p. 200–249
  11. Watanabe T, Endo A. Teratogenic effects of maternal biotin deficiency on mouse embryos examined at midgestation. Teratology. 1990;42:295–300
  12. Watanabe T. Morphological and biochemical effects of excessive amounts of biotin on embryonic development in mice. Experientia. 1996;52:149–154
  13. Báez-Saldaña A, Díaz G, Espinoza B, Ortega E. Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice. Am J Nutr. 1998;64:431–437
  14. Báez-Saldaña A, Ortega E. Biotin deficiency accelerates thymus involution, blocks thymocyte maturation and decreases nose-rump length in mice. J Nutr. 2004;134:1979–1987
  15. Dakshinamurti K, Modi VV, Mistry SP. Some aspects of carbohydrates metabolism in biotin-deficient rats. Proc Soc Exp Biol Med. 1968;127:396–400
  16. Dakshinamurti K, Cheah-Tan C. Biotin-mediated synthesis of hepatic glucokinase in the rat. Arch Biochem Biophys. 1968;127:17–21
  17. Dakshinamurti K, Tarrago-Litvak S, Ho Choang H. Biotin and glucose metabolism. Can J Biochem. 1970;48:493–500
  18. Spence JT, Koudelka AP. Effects of biotin upon the intracellular level of cGMP and the activity of glucokinase in cultured rat hepatocytes. J Biol Chem. 1984;259:6393–6396
  19. Chauhan J, Dakshimamurti K. Transcriptional regulation of the glucokinase gene by biotin in starved rats. J Biol Chem. 1991;266:10035–10038
  20. Romero-Navarro G, Cabrera-Valladares G, German MS, Matschinsky FM, Wang J, Fernandez-Mejia C. Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin deficient rats. Endocrinology. 1999;140:4595–4600
  21. Borboni P, Magnaterra R, Rabini RA, Staffolanni R, Porzio O, Sesti G, et al. Effect of biotin on glucokinase activity, mRNA expression and insulin release in cultured beta-cells. Acta Diabetol. 1996;33:154–158
  22. De la Vega L, Stockert R. Regulation of the insulin and asialoglycoprotein receptors via cGMP-dependent protein kinase. Am J Physiol Cell Physiol. 2000;279:C2037–C2042
  23. Dakshinamurti K, Li W. Transcriptional regulation of liver phosphoenolpyruvate carboxykinase by biotin in diabetic rats. Mol Cell Biochem. 1994;132:127–132
  24. Solorzano-Vargas S, Pacheco-Alvarez D, Leon-Del-Rio A. Holocarboxylase synthetase is an obligate participant in biotin-mediated regulation of its own expression and of biotin-dependent carboxylases mRNA levels in human cells. Proc Natl Acad Sci U S A. 2002;99:5325–5330
  25. Rodriguez-Melendez R, Cano S, Mendez ST, Velazquez A. Biotin regulates the genetic expression of holocarboxylase synthetase and mitochondrial carboxylases in rats. J Nutr. 2001;131:1909–1913
  26. Deodhar AD, Mistry SP. Control of glycolisis in biotin deficient rat liver. Life Sci. 1970;9:581–588
  27. Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Takao S. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin diabetes mellitus. J Clin Biochem Nutr. 1993;14:211–218
  28. Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma glucose levels in diabetics. Ann N Y Acad Sci. 1985;447:389–392
  29. Mock DM, Mock NI. Lymphocyte propionyl–CoA carboxylase is an early and sensitive indicator of biotin deficiency in rats, but urinary excretion of 3-hidroypropionic acid is not. J Nutr. 2002;132:1945–1950
  30. Velázquez A, Terán M, Báez A, Gutierrez J, Rodríguez R. Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. Am J Clin Nutr. 1995;61:385–391
  31. Báez-Saldaña A, Zendejas-Ruiz I, Revilla-Monsalve C, Islas-Andrade S, Cárdenas A, Rojas-Ochoa A, et al. Effects of biotin on pyruvate carboxylase, acetyl–CoA carboxylase, propionyl CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and in nondiabetic subjects. Am J Clin Nutr. 2004;79:238–243
  32. Reddi A, DeAngelis B, Frank O, Lasker N, Baker H. Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice. Life Sci. 1988;42:1323–1330
  33. Zhang H, Osada K, Maebashi M, Ito M, Komai M, Furukawa Y. A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. J Nutr Sci Vitaminol. 1996;42:517–526
  34. Koustikos D, Fourtounas C, Kapetanaki A, Agroyannis B, Tzanatos H, Rammos G, et al. Oral glucose test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Ren Fail. 1966;18:131–137
  35. CristinaFernandez-Mejia C, Zendejas-Ruiz I, Revilla Monsalve C, Islas-Andrade S, Báez-Saldaña A, Cárdenas A, et al. Biotin treatment increases insulin sensitivity in type 2 diabetics. American Diabetes Association 63rd Scientific Sessions. Diabetes. 2003;52(Suppl):A459
  36. Marshall MW, Smith BP, Lehman RP. Dietary response of two genetically different lines of inbred rats: lipids in serum and liver. Proc Soc Exp Biol Med. 1969;131:1271–1277
  37. Marshall MW, Haubrich M, Washington VA, Chang MW, Young CW, Wheeler MA. Biotin status and lipid metabolism in adult obese hypercholesterolemic inbred rats. Nutr Metab. 1976;20:41–61
  38. Marshall MW, Kliman PG, Washington VA. Effects of biotin on lipids and on other constituents of plasma of healthy men and women. Artery. 1980;7:330–351
  39. Steigerwal H, Bohele H. On the influence of biotin upon the intermediated metabolism. In: Internat. Sympos. on drugs affecting lipid metab, June 2–4; Milan, Italy. 1960;p. 484–486
  40. Dukusova OD, Krivoruchenko IV. The effect of biotin on the blood cholesterol levels of atherosclerotic patients in idiopathic hyperlipidemia. Kardiologiia. 1972;12:113
  41. Lewis B, Rathman S, McMahon R. Dietary biotin intake modulates the pool of free and protein-bound biotin in rat liver. J Nutr. 2001;131:2310–2315
  42. Munday MR, Hemingway CJ. The regulation of acetyl–CoA carboxylase — a potential target for the action of hypolipidemic agents. Adv Enzyme Regul. 1999;39:205–234
  43. Ganji SH, Kamanna VS, Kashyap ML. Niacin and cholesterol: role in cardiovascular disease. (review) J Nutr Biochem. 2003;14298–14305
  44. Ito MK. Niacin-based therapy for dyslipidemia: past evidence and future advances. Am J Manag Care. 2002;8:S315–S322
  45. Mukherjee R, Davies P, Crombie DL, Bischoff ED, Cesario RM, Jow L, et al. Sensitization of diabetic and obese mice to insulin by retinoic X receptor agonist. Nature. 1997;386:407–410
  46. Liu YL, Sennitt MV, Hislop DC, Crombie DL, Heyman RA, Cawthorne MA. Rexinoid X receptor agonists have anti-obesity effects and improve insulin sensitivity in Zucker fa/fa rats. Int J Obes Relat Metab Disord. 2000;24:997–1004

PII: S0955-2863(05)00092-6

doi: 10.1016/j.jnutbio.2005.03.018

The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 424-427 , July 2005

Article Tools