The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 398-401 , July 2005

Improved absorption of caseinophosphopeptide-bound iron: role of alkaline phosphatase

  • Bertille Ani-Kibangou

      Affiliations

    • Laboratoire de Physiologie Digestive et Nutritionnelle, CHU de Caen, F-14033 Caen Cedex, France
    • ,
  • Saïd Bouhallab

      Affiliations

    • Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de St-Brieuc, F-35042 Rennes Cedex, France
    • ,
  • Daniel Mollé

      Affiliations

    • Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de St-Brieuc, F-35042 Rennes Cedex, France
    • ,
  • Gwénaële Henry

      Affiliations

    • Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de St-Brieuc, F-35042 Rennes Cedex, France
    • ,
  • François Bureau

      Affiliations

    • Laboratoire de Biochimie A, CHU de Caen, F-14033 Caen Cedex, France
    • ,
  • Dominique Neuville

      Affiliations

    • Laboratoire de Biochimie A, CHU de Caen, F-14033 Caen Cedex, France
    • ,
  • Pierre Arhan

      Affiliations

    • Laboratoire de Physiologie Digestive et Nutritionnelle, CHU de Caen, F-14033 Caen Cedex, France
    • ,
  • Dominique Bouglé

      Affiliations

    • Laboratoire de Physiologie Digestive et Nutritionnelle, CHU de Caen, F-14033 Caen Cedex, France
    • Corresponding Author InformationCorresponding author. Service de Pédiatrie A, CHU Clémenceau, CHU de Caen, F-14033 Caen Cedex, France. Tel.: +33 2 31 27 25 90; fax: +33 2 31 27 26 55.

Received 4 January 2005 ,Revised 22 February 2005 ,Accepted 24 February 2005.

References 

  1. Bothwell TH. Overview and mechanisms of iron regulation. Nutr Rev. 1995;53:237–245
  2. Hurrell RF, Lynch SR, Trinidad TP, Dassenko SA, Cook JD. Iron absorption in humans as influenced by bovine milk proteins. Am J Clin Nutr. 1989;49:546–552
  3. Brulé G, Fauquant J. Interactions des protéines du lait et des oligoéléments. Lait. 1982;62:323–331
  4. Bouhallab S, Léonil J, Maubois JL. Complexation du fer par le phosphopeptide (1–25) de la caséine β: action de l'alcalase et de la phosphatase acide. Lait. 1991;71:435–443
  5. Gaucheron F, Le Graet Y, Boyaval E, Piot M. Binding of cations to casein molecules: importance of physicochemical conditions. Milchwissenschaft. 1997;52:322–327
  6. Kasai T, Iwasaki R, Tanaka M, Kiriyama S. Casein phosphopeptides (CPP) in faeces and contents in faeces and contents in digestive tract of rats fed casein and CPP preparations. Biosci Biotechnol Biochem. 1995;59:26–30
  7. Bouhallab S, Oukheter N, Mollé D, Henry G, Maubois JL, Arhan P, et al. Sensitivity of beta-casein phosphopeptide–iron complex to digestive enzymes in ligated segment of rat duodenum. J Nutr Biochem. 1999;10:723–727
  8. Aït-Oukhatar N, Bouhallab S, Bureau F, Arhan P, Maubois JL, Bouglé D. In vitro digestion of caseinophosphopeptide–iron complex. J Dairy Res. 2000;67:125–129
  9. Aït-Oukhatar N, Bouhallab S, Arhan P, Maubois JL, Drosdowsky M, Bouglé D. Iron tissue storage and hemoglobin levels of deficient rats repleted with iron bound to the caseinophosphopeptide 1–25 of beta-casein. J Agric Food Chem. 1999;47:2786–2790
  10. Chaud MV, Izumi C, Nahaal Z, Shuhama T, Bianchi ML, Freitas O. Iron derivatives from casein hydrolysates as a potential source in the treatment of iron deficiency. J Agric Food Chem. 2002;50:871–877
  11. Yeung AC, Glahn RP, Miller DD. Effects of iron source on iron availability from casein and casein phosphopeptides. J Food Sci. 2002;67:1271–1275
  12. Yeung AC, Glahn RP, Miller DD. Dephosphorylation of sodium caseinate, enzymatically hydrolyzed casein and casein phosphopeptides by intestinal alkaline phosphatase: implications for iron availability. J Nutr Biochem. 2001;12:292–299
  13. Bouhallab S, Cinga V, Ait-Oukhatar N, Bureau F, Neuville D, Arhan P, et al. Influence of various phosphopeptides of caseins on iron absorption. J Agric Food Chem. 2002;50:7127–7130
  14. O'Brien PJ, Herschlag D. Alkaline phosphatase revisited: hydrolysis of alkyl phosphates. Biochemistry. 2002;41:3207–3225
  15. Aït-Oukhatar N, Pérès JM, Bouhallab S, Neuville D, Bureau F, Bouvard G, et al. Bioavailability of caseinophosphopeptide-bound iron. J Lab Clin Med. 2002;140:290–294
  16. Sato R, Noguchi T, Naito H. The necessity for the phosphate portion of casein molecules to enhance Ca absorption from small intestine. Agric Biol Chem. 1983;10:2415–2417
  17. Meisel H, Bernard H, Fairweather-Tait S, FitzGerald RJ, Hartmann R, Lane CN, et al. Detection of caseinophosphopeptides in the distal ileostomy fluid of human subjects. Br J Nutr. 2003;89:351–359
  18. Ferraretto A, Signorile A, Gravaghi C, Fiorilli A, Tettamanti G. Casein phosphopeptides influence calcium uptake by cultured human intestinal HT-29 tumor cells. J Nutr. 2001;131:1655–1661
  19. Fitzgerald RJ. Potential uses of caseinophosphopeptides. Int Dairy J. 1998;8:451–457

PII: S0955-2863(05)00057-4

doi: 10.1016/j.jnutbio.2005.02.008

The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 398-401 , July 2005

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