« Previous
Next »
The Journal of Nutritional Biochemistry
Volume 16, Issue 8
, Pages 467-478
, August 2005
Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. A pilot study
References
- . Optimal diets for prevention of coronary heart disease. JAMA. 2002;288:2569–2578
- . Effect of diet on vascular reactivity: an emerging marker for vascular risk. Curr Atheroscler Rep. 2001;3:446–455
- . Homocysteine, folate, and cardiovascular disease. Int J Vitam Nutr Res. 2001;71:173–178
- . Is there more to folates than neural-tube defects?. Proc Nutr Soc. 2003;62:591–598
- . Role of folate in colon cancer development and progression. J Nutr. 2003;133:3731S–3739S
- Folate and breast cancer: the role of polymorphisms in methylenetetrahydrofolate reductase (MTHFR). Cancer Lett. 2002;181:65–71
- . Beneficial role for folate in the prevention of colorectal and breast cancer. Eur J Nutr. 2001;40:98–105
- . Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol Genet Metab. 2000;71:121–138
- . DNA stability and genomic methylation status in colonocytes isolated from methyl-donor-deficient rats. Eur J Nutr. 2000;39:106–111
- . Impact of folate deficiency on DNA stability. J Nutr. 2002;132:2444S–2449S
- . Biomarkers of genetic damage for cancer epidemiology. Toxicology. 2002;181–182:411–416
- . Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes—evidence for breakage–fusion–bridge cycles in the cytokinesis-block micronucleus assay. Mutat Res. 2002;504:131–136
- Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A. 1997;94:3290–3295
- . DNA damage in folate deficiency. Baillieres Clin Haematol. 1995;8:461–478
- . Folate and vitamin B12. Proc Nutr Soc. 1999;58:441–448
- Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet. 1997;349:1591–1593
- . A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64:169–172
- Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen. 2000;35:206–221
- . Prevalence and role of methylenetetrahydrofolate reductase 677 C→T and 1298 A→C polymorphisms in coronary artery disease in Arabs. Arch Pathol Lab Med. 2003;127:1349–1352
- . Microgel electrophoresis: sensitivity, mechanisms, and DNA electrostretching. Mutat Res. 1997;383:167–175
- . Oxidation of cellular DNA measured with the comet assay. Methods Mol Biol. 2002;186:147–159
- . Increased uracil misincorporation in lymphocytes from folate-deficient rats. Br J Cancer. 2000;83:1532–1537
- . The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimidines) and growth in human cells. Mutat Res. 1997;390:141–151
- . Uracil misincorporation in human DNA detected using single cell gel electrophoresis. Carcinogenesis. 1997;18:1709–1714
- . DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB J. 1998;12:1491–1497
- . DNA damage and repair in lymphocytes of normal individuals and cancer patients: studies by the comet assay and micronucleus tests. Acta Biochim Pol. 2003;50:181–190
- . Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis. 2003;24:511–515
- . Red cell N5-methyltetrahydrofolate concentrations and C677T methylenetetrahydrofolate reductase genotype in patients with stroke. J Clin Pathol. 2004;57:54–57
- Red blood cell methylfolate and plasma homocysteine as risk factors for venous thromboembolism: a matched case-control study. Lancet. 2002;359:747–752
- . The study of folate consumption in a group of women at childbearing age. Zyw Czlow Metab. 2000;XXVII:172–183
- . Pathobiology and genetics of neural tube defects. Epilepsia. 2003;44(Suppl 3):14–23
- . Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice. Teratology. 2002;65:63–69
- . Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. Am J Med Genet. 2002;108:1–6
- . MTHFR gene polymorphism, homocysteine and cardiovascular disease. Public Health Nutr. 2001;4:493–497
- . The methylenetetrahydrofolate reductase gene is associated with increased cardiovascular risk in Japan, but not in other populations. Atherosclerosis. 2000;153:161–168
- . Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr. 2002;132:2350S–2355S
- . Nutrition, genetics, and risks of cancer. Annu Rev Public Health. 2000;21:47–64
- Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver. Clin Chem Lab Med. 2003;41:1012–1019
- . Molecular targets for nutrients involved with cancer prevention. Nutr Cancer. 2001;41:1–16
- . Folic acid as a cancer-preventing agent. Med Hypotheses. 1995;45:297–303
- . Folate and cancer. Ai Zheng. 2003;22:668–671
- . Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event. Mol Genet Metab. 2003;79:201–213
- . Dietary factors affecting spontaneous chromosomal damage in man. Prog Clin Biol Res. 1990;347:139–153
- 5,10-Methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SUVI.MAX) cohort. Br J Nutr. 2000;84:891–896
- The role of vitamin B12 in fasting hyperhomocysteinemia and its interaction with the homozygous C677T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. A case-control study of patients with early-onset thrombotic events. Thromb Haemost. 2000;83:563–570
- . Folate intake in Europe: recommended, actual and desired intake. Eur J Clin Nutr. 1997;51:643–660
- . The role of folic acid and vitamin B12 in genomic stability of human cells. Mutat Res. 2001;475:57–67
- Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J Nutr. 1999;129:1135–1139
- . Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism. Clin Chem. 2000;46:1065–1071
- . Folate, vitamin B12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis. 1997;18:1329–1336
- . Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 1998;19:1163–1171
- . Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement. J Nutr. 1999;129:919–922
- Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: effect of folate supplementation. Am J Gastroenterol. 1998;93:2060–2064
- . Genetic defects of folate and cobalamin metabolism. Eur J Pediatr. 1998;157(Suppl 2):S60–S66
- . Recommended dietary allowances (RDAs) for genomic stability. Mutat Res. 2001;480–481:51–54
- Folate status, metabolic genotype, and biomarkers of genotoxicity in healthy subjects. Carcinogenesis. 2003;24:1097–1103
- . Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs). Food Chem Toxicol. 2002;40:1113–1117
- . Micronutrient deficiencies. A major cause of DNA damage. Ann N Y Acad Sci. 1999;889:87–106
- . Micronutrients prevent cancer and delay aging. Toxicol Lett. 1998;102–103:5–18
- . Folate bioavailability and health. Int J Vitam Nutr Res. 2002;72:46–52
- . Nutrition and maternal morbidity and mortality. Br J Nutr. 2001;85(Suppl 2):S93–S99
- . Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr. 2001;85(Suppl 2):S109–S113
- . An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy. Mol Genet Metab. 2001;73:322–332
- . Nutrition during pregnancy—do recommendations and practice meet?. Duodecim. 2001;117:149–155
- . Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia. Eur J Pediatr. 1998;157(Suppl 2):S131–S134
- . 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151:862–877
- . C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): its frequency and impact on plasma homocysteine concentration in different European populations. EARS group. Atherosclerosis. 1998;136:347–354
- The high prevalence of thermolabile 5-10 methylenetetrahydrofolate reductase (MTHFR) in Italians is not associated to an increased risk for coronary artery disease (CAD). Thromb Haemost. 1998;79:727–730
- Genetic polymorphisms associated with acute pulmonary embolism and deep venous thrombosis. Eur Respir J. 2003;21:25–30
- . Mutations C677T and A1298C of the 5,10-methylenetetrahydrofolate reductase gene and fasting plasma homocysteine levels are not associated with the increased risk of venous thromboembolic disease. Blood Coagul Fibrinolysis. 2002;13:423–431
- A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?. Am J Hum Genet. 1998;62:1044–1051
- Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood. 2001;97:3205–3209
- Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia. Am J Med Genet. 2001;101:36–39
- Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease. Atherosclerosis. 2003;167:205–214
- . Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutr Cancer. 2000;37:245–251
- . Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats. Carcinogenesis. 1997;18:287–293
- . Uracil misincorporation, DNA strand breaks, and gene amplification are associated with tumorigenic cell transformation in folate deficient/repleted Chinese hamster ovary cells. Cancer Lett. 1999;146:35–44
- . A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tertrahydrofolates in red blood cells. Proc Natl Acad Sci U S A. 1998;95:13217–13220
- . The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiol Biomarkers Prev. 2001;10:1089–1096
- Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proc Natl Acad Sci U S A. 1999;96:12810–12815
- Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004;103:252–257
- . The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukemia. Br J Haematol. 2001;115:616–618
- . Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci U S A. 2001;98:4004–4009
PII: S0955-2863(05)00052-5
doi: 10.1016/j.jnutbio.2005.01.018
© 2005 Elsevier Inc. All rights reserved.
« Previous
Next »
The Journal of Nutritional Biochemistry
Volume 16, Issue 8
, Pages 467-478
, August 2005
