The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 402-409 , July 2005

Promotion of adenoma growth by dietary inulin is associated with increase in cyclin D1 and decrease in adhesion proteins in Min/+ mice mucosa

Received 8 November 2004 ,Revised 3 January 2005 ,Accepted 10 January 2005.

References 

  1. Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, et al. APC mutation occur early during colorectal tumorigenesis. Nature. 1992;359:235–237
  2. Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science (Wash DC). 1990;47:322–324
  3. Su LK, Kinzler KW, Vogelstein B, Preisenger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homology of the APC gene. Science (Wash DC). 1992;256:668–670
  4. Kinzler KW, Vogelstein B. Lesson from hereditary colorectal cancer. Cell. 1996;87:159–170
  5. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell. 2000;103:311–320
  6. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature (Lond). 1999;398:422–426
  7. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc Natl Acad Sci U S A. 1999;96:5522–5527
  8. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of APC pathway. Science (Wash DC). 1998;281:1509–1512
  9. Cowin P. Unraveling the cytoplasmic interactions of the cadherin superfamily. Proc Natl Acad Sci U S A. 1994;91:10759–10761
  10. Hao X, Tomlinson I, Ilyas M, Palazzo JP, Talbot IC. Reciprocity between membranous and nuclear expression of β-catenin in colorectal tumors. Virchows Arch. 1997;431:167–172
  11. Hugh TJ, Dillon SA, O'Dowd G, Getty B, Pignatelli M, Poston GJ, et al. β-Catenin expression on primary and metastatic colorectal carcinoma. Int J Cancer. 1999;82:504–511
  12. Hao XP, Pretlow TG, Rao JS, Pretlow TP. β-Catenin expression is altered in human colonic aberrant crypt foci. Cancer Res. 2001;61:8085–8088
  13. Hazan RB, Qiao R, Keren R, Badano I, Suyama K. Cadherin switch in tumor progression. Ann N Y Acad Sci. 2004;1014:155–163
  14. Sherr CJ. G1 phase progression: Cycling on cue. Cell. 1994;79:551–555
  15. Weinberg RA. Retinoblastoma protein and cell cycle control. Cell. 1995;81:323–330
  16. Dyson N. The regulation of E2F by pRb-family proteins. Genes Dev. 1998;12:2245–2262
  17. Bartkova J, Thullenberg M, Slezak P, Jaramillo E, Rubio C, Thomassen LH, et al. Aberrant expression of G1-phase cell cycle regulators in flat and exophytic adenomas of the human colon. Gastroenterology. 2001;120:1680–1688
  18. Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M, et al. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology. 1996;110:669–674
  19. Zhang T, Nanney LB, Luongo C, Lamps L, Heppner KJ, DuBois RN, et al. Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 1997;57:169–175
  20. Wali RK, Khare S, Tretiakova M, Cohen G, Nguyen L, Hart J, et al. Ursodeoxycholic acid and F6-D3 inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. Cancer Epidemiol Biomarkers Prev. 2002;11:1653–1662
  21. Shinozaki H, Yang K, Fan K, Edelmann W, Kucherlapati R, Weinstein IB, et al. Cyclin D1 expression in the intestinal mucosa and tumours of Apc1638N mice. Anticancer Res. 2003;23:2217–2226
  22. Orner GA, Dashwood WM, Blum CA, Díaz GD, Li Q, Dashwood RH. Suppression of tumorigenesis in the ApcMin mouse: Down-regulation of β-catenin signaling by a combination of tea plus sulindac. Carcinogenesis. 2003;24:263–267
  23. Yang WC, Bancroft L, Nicholas C, Lozonschi I, Augenlicht LH. Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a Western-style high-risk diet. Cancer Res. 2003;63:4990–4996
  24. Mutanen M, Pajari AM, Oikarinen S. Beef induces and rye bran prevents the formation of intestinal polyps in ApcMin mice: relation to catenin and PKC isozymes. Carcinogenesis. 2000;21:1167–1173
  25. Pajari AM, Rajakangas J, Päivärinta E, Kosma VM, Rafter J, Mutanen M. Promotion of intestinal tumor formation by inulin is associated with an accumulation of cytosolic β-catenin in Min mice. Int J Cancer. 2003;106:653–660
  26. Salminen HK, Pajari AM, Mutanen M. Relationship between β-catenin and tumor growth. In: Abstract in EMBO Conference: Oncogenes and Growth Control, Heidelberg, Germany, April 17–20. 2004;
  27. Dietrich WF, Lander ES, Smith JS, Moser AR, Gould KA, Luongo C, et al. Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell. 1993;75:631–639
  28. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition Ad Hoc Committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939–1951
  29. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signalling in cancer. Biochim Biophys Acta. 2003;1653:1–24
  30. Orsulic S, Huber O, Aberle H, Arnold S, Kemler R. E-Cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation. J Cell Sci. 1999;112:1237–1245
  31. Gottardi CJ, Wong E, Gumbiner BM. E-Cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol. 2001;153:1049–1060
  32. Mahmoud NN, Boolbol SK, Bilinski RT, Martucci C, Chadburn A, Bertagnolli MM. Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration. Cancer Res. 1997;57:5045–5050
  33. Carothers AM, Melstrom KA, Mueller JD, Weyant MJ, Bertagnolli MM. Progressive changes in adherence junction structure during intestinal adenoma formation in APC mutant mice. J Biol Chem. 2001;276:39094–39102
  34. Bissonnette M, Khare S, von Lintig FC, Wali RK, Nguyen L, Zhang Y, et al. Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1. Cancer Res. 2000;60:4602–4609
  35. Wilding J, Straub J, Bee J, Churchman M, Bodmer W, Dickson C, et al. Cyclin D1 is not an essential target of β-catenin signaling during intestinal tumorigenesis, but it may act as a modifier of disease severity in multiple intestinal neoplasia (Min) mice. Cancer Res. 2002;62:4562–4565
  36. Hulit J, Wang C, Li Z, Albanese C, Rao M, Di Vizio D, et al. Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice. Mol Cell Biol. 2004;24:7598–7611
  37. Akedo I, Ishikawa H, Ioka T, Kaji I, Narahar H, Ishiguro S, et al. Evaluation of epithelial cell proliferation rate in normal-appearing colonic mucosa as a high-risk marker for colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2001;10:925–930
  38. Hur K, Kim JR, Yoon BI, Lee JK, Choi JH, Oh GT, et al. Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis. J Vet Sci. 2000;1:121–126
  39. Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Cyclin D1: normal and abnormal functions. Endocrinology. 2004;145:5439–5447
  40. Verghese M, Rao DR, Chawan CB, Williams LL, Shackelford L. Dietary inulin suppresses azomethane-induced aberrant crypt foci and colon tumors at the promotion stage in young fisher 344 rats. J Nutr. 2002;132:2809–2813
  41. Rowland IR, Rumney CJ, Coutts JT, Lievense LC. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis. 1998;19:281–285
  42. Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, et al. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis. 2002;23:1953–1960
  43. Takahashi M, Wakabayashi K. Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents. Cancer Sci. 2004;95:475–480
  44. O'Shaughnessy JA, Kelloff GJ, Gordon GB, Dannenberg AJ, Hong WK, Fabian CJ, et al. Treatment and prevention of intraepithelial neoplasia: An important target for accelerated new agent development. Clin Cancer Res. 2002;8:314–346
  45. Ten Bruggencate SJM, Bovee-Oudenhoven IMJ, Lettink-Wissink MLG, Katan MB, Van der Meer R. Dietary fructo-oligosaccharides dose-dependently increase translocation of salmonella in rats. J Nutr. 2003;133:2313–2318

PII: S0955-2863(05)00031-8

doi: 10.1016/j.jnutbio.2005.01.013

The Journal of Nutritional Biochemistry
Volume 16, Issue 7 , Pages 402-409 , July 2005

Article Tools

* Image Usage & Resolution