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The Journal of Nutritional Biochemistry
Volume 12, Issue 11
, Pages 640-647
, November 2001
β-Carotene 15,15′-Dioxygenase activity in human tissues and cells: evidence of an iron dependency
References
-
.
The enzymatic cleavage of β-carotene into vitamin A by soluble enzymes of rat liver and intestine.
Proc. Natl. Acad. Sci. USA. 1965;54:1364–1370
- . Biosynthesis of vitamin A with rat intestinal enzymes. Science. 1965;149:879–880
- . Retinoic acid (Its biosynthesis and metabolism). Prog. Nucleic Acid Res. Mol. Biol. 2000;63:139–188
- . Filling the gap in vitamin A research. J. Biol. Chem. 2000;275:11915–11920
- . Cloning and expression of β,β-carotene 15,15′-dioxygenase. Biochem. Biophys. Res. Commun. 2000;271:334–336
- . Identification, expression, and substrate specificity of a mammalian β-carotene 15,15′-dioxygenase. J. Biol. Chem. 2001;276:6560–6565
-
.
Analysis of the blind Drosophila mutant ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo.
Proc. Natl. Acad. Sci. USA. 2001;98:1130–1135
- . Carotene dioxygenase (EC 1.13.11.21) in rat intestine (effects of vitamin A deficiency and of pregnancy). Br. J. Nutr. 1986;56:115–122
-
.
Effect of vitamin A and β-carotene intake on dioxygenase activity in rat intestine.
Ann. NY Acad. Sci. 1993;691:220–222
- . β-Carotene 15,15′-dioxygenase (EC 1.13.11.21) isolation reaction mechanism and an improved assay procedure. Br. J. Nutr. 1994;72:397–414
- . Rat intestinal β-carotene dioxygenase is located primarily in the cytosol of mature jejunal enterocytes. J. Nutr. 1996;126:2550–2556
- . Assay of β-carotene 15,15′-dioxygenase activity by reverse-phase high-pressure liquid chromatography. Anal. Biochem. 1996;241:199–205
-
.
Enzymatic conversion of all-trans-β-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa.
Proc. Nat. Acad. Sci. USA. 1989;86:9124–9128
- . Enzymatic cleavage of carotenoids. Biochim. Biophys. Acta. 1974;370:49–61
-
.
Properties of β-carotene 15,15′-dioxygenase stabilized by lutein and dithiothreitol during isolation.
Biokhim. 1993;58:416–423
- . Review of animal models in carotenoid research. J. Nutr. 1999;129:2271–2277
- . Conversion of all trans β-carotene to retinal by an enzyme from the intestinal mucosa of human neonates. J. Nutr. Biochem. 1993;4:659–663
- . Characterization of β-carotene 15,15′-dioxygenase activity in TC7 clone of human intestinal cell line Caco-2. Biochem. Biophys. Res. Commun. 1998;249:467–474
-
.
The enzymatic conversion of all-trans β-carotene into retinal.
J. Biol. Chem. 1967;242:3543–3554
- . β-Carotene 15,15′-dioxygenase activity is responsive to copper and iron concentrations in rat small intestine. J. Am. Coll. Nutr. 1999;18:309–315
- . Intestinal β-carotene 15,15′-dioxygenase activity is markedly enhanced in copper-deficient rats fed high-iron diets and fructose. Br. J. Nutr. 2000;84:117–124
-
.
Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2 (evidence for glucose-dependent negative regulation).
J. Cell Sci. 1994;107:213–225
- . A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976;72:248–254
- . The intestinal absorption and metabolism of vitamin A and β-carotene in man. J. Clin. Invest. 1966;45:1615–1622
- . The conversion of radioactive β-carotene into vitamin A by the rat intestine in vivo. J. Biol. Chem. 1961;236:349–356
- . Stoichiometric conversion of all trans-β-carotene to retinal by pig intestinal extract. Arch. Biochem. Biophys. 1996;328:57–63
-
.
Dietary intake of carotenes and the carotene gap.
Clin. Nutr. 1988;7:118–122
- . Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells. J. Nutr. 1995;125:1291–1299
- . A ferric reductase activity is found in brush border membrane vesicles isolated from Caco-2 cells. J. Nutr. 1996;126:2209–2217
- . Iron-chelating therapy and the treatment of thalassemia. Blood. 1997;89:739–761
- . Inhibition of β-carotene 15,15′-dioxygenase activity by dietary flavonoids. J. Nutr. Biochem. 2000;11:348–355
PII: S0955-2863(01)00184-X
© 2001 Elsevier Science Inc. All rights reserved.
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The Journal of Nutritional Biochemistry
Volume 12, Issue 11
, Pages 640-647
, November 2001
