The Journal of Nutritional Biochemistry
Volume 12, Issue 11 , Pages 631-639 , November 2001

β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans

  • Matthew D Vukovich

      Affiliations

    • Applied Physiology Laboratory, South Dakota State University, Brookings, South Dakota, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-605-688-6580; fax: +1-605-688-5999
    • ,
  • Gary Slater

      Affiliations

    • Sports Science Sports Medicine Division, Australian Institute of Sport, Belconnen ACT Australia, Office of Rural Health Department of Health and Aged Care Canberra ACT, Australia
    • ,
  • Martina B Macchi

      Affiliations

    • Human Performance Laboratory, Wichita State University, Wichita, Kansas, USA
    • ,
  • Michael J Turner

      Affiliations

    • Department of Health Promotion and Kinesiology, University of North Carolina, Charlotte, Charlotte, North Carolina, USA
    • ,
  • Keiren Fallon

      Affiliations

    • Sports Science Sports Medicine Division, Australian Institute of Sport, Belconnen ACT Australia, Office of Rural Health Department of Health and Aged Care Canberra ACT, Australia
    • ,
  • Tanya Boston

      Affiliations

    • Sports Science Sports Medicine Division, Australian Institute of Sport, Belconnen ACT Australia, Office of Rural Health Department of Health and Aged Care Canberra ACT, Australia
    • ,
  • John Rathmacher

      Affiliations

    • Metabolic Technologies, Inc. Ames, Iowa, USA

Received 14 December 2000 ,Revised 5 May 2001 ,Accepted 16 July 2001.

References 

  1. May ME, Buse MG. Effects of branched-chain amino acids on protein turnover, Diabetes/Metab. Reviews. 1989;5:227–245
  2. Kimball SR, Horetsky RL, Jeffereson LS. Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts. J. Biol. Chem. 1998;273:30945–30953
  3. Kimball SR, Shantz LM, Horetsky RL, Jefferson LS. Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6. J. Biol. Chem. 1999;274:11647–11652
  4. Anthony JC, Anthony TG, Kimball SR, Vary TC, Leonard LS. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J. Nutr. 2000;130:139–145
  5. Nissen S, Sharp R, Ray M, Rathmacher JA, Rice D, Fuller JC, et al. Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training. J. Appl. Physiol. 1996;81:2095–2104
  6. Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate (HMB). J. Nutr. Biochem. 1997;8:300–311
  7. Ostaszewski P, Kostiuk S, Balaskinska B, Papet I, Glomot F, Nissen S. The effect of the leucine metabolite 3-hydroxy-3methylbutyrate (HMB) on muscle protein synthesis and protein breakdown in chick and rat muscle. J. Anim. Sci. 1996;74:138;(Abstract)
  8. Van Koevering M, Nissen S. Oxidation of leucine and αketoisocaproate to β-hydroxy-β-methylbutyrate in vivo. Am. J. Physiol. 1992;262:E27–E31
  9. Zhang Z, Talleyrand V, Rathmacher J, Nissen S. Change in plasma β-hydroxy-β-methylbutyrate (HMB) by feeding leucine, αketoisocaprate (KIC) and isovaleric acid (IVA) to pigs. FASEB J. 1993;7:A392;(Abstract)
  10. Green AL, Simpson EJ, Littlewood JJ, Macdonald IA, Greenhaff PL. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol. Scand. 1996;158:195–202
  11. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am. J. Physiol. 1996;271:E821–E826
  12. Pollock ML, Schmidt DH, Jackson AS. Measurement of cardiorespiratory fitness and body composition in the clinical setting. Comprehensive Therapy. 1980;6:12–27
  13. Nissen S, Van Koevering M, Webb D. Analysis of beta-hydroxy-beta-methyl butyrate in plasma by gas chromatography and mass spectrometry. Anal. Biochem. 1990;188:17–19
  14. Morgan DR, Lazarow A. Immunoassay of insulin (two antibody system). Diabetes. 1963;12:115–126
  15. Costill DL, Saltin B. Factors limiting gastric emptying during rest and exercise. J. Appl. Physiol. 1974;37:679–683
  16. Hagg SA, Morse EL, Adibi SA. Effect of exercise on rates of oxidation turnover, and plasma clearance of leucine in human subjects. Am. J. Physiol. 1982;242:E407–E410
  17. Rennie MJ, Halliday D, Davies CMT, Edwards RHT, Krywawych S, Millward DJ, et al. Exercise induced increase in leucine oxidation in man and the effect of glucose. Develop. Biochem. 1981;18:361–366
  18. Wolfe RR, Goodenough RD, Wolfe MH, Royle GT, Nadel ER. Isotopic analysis of leucine and urea metabolism in exercising humans. J. Appl. Physiol. 1982;52:458–466
  19. M.D. Vukovich, G.D. Dreifort, The effect of β-hydroxy βmethylbutyrate (HMB) on the onset of blood lactate accumulation and VO2peak in endurance trained cyclists. J. Strength Cond. Research. In press.

PII: S0955-2863(01)00182-6

The Journal of Nutritional Biochemistry
Volume 12, Issue 11 , Pages 631-639 , November 2001

Article Tools

* Image Usage & Resolution